Results 1 to 10 of about 8,086 (216)

Pharmacokinetics study of ginsenoside Rg1 liposome by pulmonary administration [PDF]

Heliyon
Ginsenoside Rg1 (Rg1), a monomer saponin component, is one of the components with the highest content in total saponins of Panaxnotoginseng. It had various pharmacological effects.
Ping Liang, Jie Zhang, Juan Hou, Rui Feng, Jintuo Yin   +4 more
doaj   +4 more sources

Does ginsenoside Rg1 promote intervertebral disc repair? An experimental study insights into ferroptosis mechanism [PDF]

Journal of Translational Medicine
Background Intervertebral disc degeneration (IVDD) is a complex and multifactorial condition characterized by the progressive deterioration of the intervertebral discs.
Dongliang Gong, Feiyun Xia, Fuyong Wang, Xiaoxia Tong, Qing Yang, Kelv Shen, Baihan Sun, Nong Chen, Zhengfeng Lu   +8 more
doaj   +2 more sources

Ginsenoside Rg1 as a Multifunctional Therapeutic Agent: Pharmacological Properties, Molecular Mechanisms and Clinical Perspectives in Complementary Medicine. [PDF]

Food Sci Nutr
Ginsenoside Rg1 (Rg1) from Panax ginseng shows multifunctional health effects. Although oral bioavailability is low and blood–brain barrier (BBB) penetration is limited, delivery systems such as liposomes and nanoparticles may improve exposure. Rg1 reduces inflammation/oxidative stress by inhibiting nuclear factor‐κB (NF‐κB) signaling and reactive ...
Cortés H, Lima E, Duarte-Peña L, Peña-Corona SI, Almarhoon ZM, Kaverikana R, Mangalpady SS, Shet VB, Manjeshwar N, Sharifi-Rad J, Chen JT, Leyva-Gómez G, Setzer WN, Calina D.   +13 more
europepmc   +2 more sources

A novel strategy for the protective effect of ginsenoside Rg1 against ovarian reserve decline by the PINK1 pathway [PDF]

Pharmaceutical Biology
Context The decline in ovarian reserve is a major concern in female reproductive health, often associated with oxidative stress and mitochondrial dysfunction.
Pengdi Yang, Meiling Fan, Ying Chen, Dan Yang, Lu Zhai, Baoyu Fu, Lili Zhang, Yanping Wang, Rui Ma, Liwei Sun   +9 more
doaj   +2 more sources

Ginsenoside Rg1 Ameliorates Pulmonary Hypertension by Inhibiting cGAS/STING Mediated Cell Senescence [PDF]

Drug Design, Development and Therapy
Rongzhen Ding,1– 3 Haiping Xie,4 Yu Zhang,2,3 Li Qin,3,5 Guoran Peng,2,3 Jian Yi,2,3 Junlan Tan,6 Xianya Cao,2,3 Runxiu Zheng,2,3 Aiguo Dai2 1Department of Health Management, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan ...
Ding R, Xie H, Zhang Y, Qin L, Peng G, Yi J, Tan J, Cao X, Zheng R, Dai A   +9 more
doaj   +2 more sources

Ginsenoside Rg1 suppresses cancer cell proliferation through perturbing mitotic progression

Journal of Ginseng Research, 2022
Background: Although the tumor-suppressive effects of ginsenosides in cell cycle have been well established, their pharmacological properties in mitosis have not been clarified yet.
Jihee Hong, Dasom Gwon, Chang-Young Jang
doaj   +3 more sources

The Neuroprotective Role of Ginsenoside Rg1 Against Cerebral Ischemia-Reperfusion Damage Through Inhibition of Mitophagy via Blocking Mitophagosome-Lysosome Fusion. [PDF]

Cell Prolif
The present study revealed the neuroprotective effect of ginsenoside Rg1 against cerebral ischemia–reperfusion injury through inhibition of mitophagy via blocking mitophagosome‐lysosome fusion both in vivo and in vitro models. ABSTRACT Ginsenoside Rg1 has shown promise in ameliorating cerebral ischemia–reperfusion injury (CIRI).
Ai L, Ren H, Wang Y, Liu M, Qiu Y, Feng J, Dai R, Fu W, Wang Y, Xi Z, Xu H, Wang F.   +11 more
europepmc   +2 more sources

Inhibition of caspase-1 by ginsenoside Rg1 ameliorates d-gal-induced renal aging and injury through suppression of oxidative stress and inflammation [PDF]

Renal Failure
Background The disruption of renal cell homeostasis caused by aging has attracted considerable attention. A traditional Chinese medicine, ginseng, is a potential drug for treating aging-related diseases. The study investigates the effect and mechanism of
Tingting Guo, Ting Xie, Xuejun Chen, Jingying Zhong, Zhenyu Bai, Huiyu Liang, Xiaoshan Zhao, Meixia Fang, Ya Xiao, Jun Zhang   +9 more
doaj   +2 more sources

Ginsenoside Rg1 in Parkinson's disease: from basic research to clinical applications. [PDF]

Front Pharmacol
This review provides an in-depth exploration of the potential of Ginsenoside Rg1 in the treatment of Parkinson’s disease (PD). The emphasis of this article was the therapeutic mechanisms of Rg1, which involved the reduction of inflammation, antioxidant properties, support for neuronal survival and regeneration, regulation of cellular energy processes ...
Wang Q, Wei L, Chen G, Chen Q.
europepmc   +4 more sources

Protective role of ginsenoside Rg1 in the dynamic progression of liver injury to fibrosis: a preclinical meta-analysis [PDF]

Frontiers in Pharmacology
BackgroundThe pathological progression from liver injury to fibrosis is a hallmark of liver disease, with no effective strategies to halt this transition.
Lijuan Dan, Xiuyan Li, Shuanglan Chen, Xiaojie You, Dong Wang, Tianyuan Wang, Jia Li, Wenping Liu, Jie Mu, Quansheng Feng, Quansheng Feng   +10 more
doaj   +2 more sources