Results 1 to 10 of about 5,699 (128)

Pharmacokinetics study of ginsenoside Rg1 liposome by pulmonary administration [PDF]

Heliyon
Ginsenoside Rg1 (Rg1), a monomer saponin component, is one of the components with the highest content in total saponins of Panaxnotoginseng. It had various pharmacological effects.
Ping Liang, Jie Zhang, Juan Hou, Rui Feng, Jintuo Yin   +4 more
exaly   +4 more sources

Does ginsenoside Rg1 promote intervertebral disc repair? An experimental study insights into ferroptosis mechanism [PDF]

Journal of Translational Medicine
Background Intervertebral disc degeneration (IVDD) is a complex and multifactorial condition characterized by the progressive deterioration of the intervertebral discs.
Dongliang Gong, Feiyun Xia, Fuyong Wang, Xiaoxia Tong, Qing Yang, Kelv Shen, Baihan Sun, Nong Chen, Zhengfeng Lu   +8 more
doaj   +2 more sources

Ginsenoside Rg1 Ameliorates the Learning and Memory Deficits of 5xFAD Mice by Inhibiting CCR3 Activity: Insights from In Vivo and In Vitro Investigations [PDF]

Pharmaceuticals
Background/Objectives: Alzheimer’s disease (AD) is characterized by amyloid-beta accumulation and neuroinflammation, yet the molecular target of Ginsenoside Rg1 remains elusive.
Hui Lu, Ying Yu, Ying Yang, He Li, Yangyi Li, Tianhao Yu, Shixue Wang, Fengzhen Li, Xiaorui Cheng   +8 more
doaj   +2 more sources

Ginsenoside Rg1 Improves PTSD-Like Sleep Disturbances in Male Mice: Involvement of NLRP3-Related Inflammatory and Apoptotic Pathways [PDF]

Neural Plasticity
Sleep disturbances (SD) are not merely symptoms of posttraumatic stress disorder (PTSD), but also amplify and perpetuate all other PTSD phenotypes. Ginsenoside Rg1 is extensively applied in managing neuropsychiatric diseases.
Chen Yang, Xinya Wang, Baobao Li, Shaojie Yang, Zhengrong Zhang, Jingji Wang, Xuncui Wang, Guoqi Zhu   +7 more
doaj   +2 more sources

A novel strategy for the protective effect of ginsenoside Rg1 against ovarian reserve decline by the PINK1 pathway [PDF]

Pharmaceutical Biology
Context The decline in ovarian reserve is a major concern in female reproductive health, often associated with oxidative stress and mitochondrial dysfunction.
Pengdi Yang, Meiling Fan, Ying Chen, Dan Yang, Lu Zhai, Baoyu Fu, Lili Zhang, Yanping Wang, Rui Ma, Liwei Sun   +9 more
doaj   +2 more sources

Improvement of Memory in Mice and Increase of Hippocampal Excitability in Rats by Ginsenoside Rg1’s Metabolites Ginsenoside Rh1 and Protopanaxatriol

Journal of Pharmacological Sciences, 2009
Ginsenoside Rg1 has been reported to improve cognitive function in many memory-impaired animal models. However, little is known about the bioactivity of its metabolites in the central nervous system in vivo.
Shi-Feng Chu, Nai-Hong Chen, Jun-Tian Zhang   +2 more
exaly   +3 more sources

Ginsenoside Rg1 Ameliorates Pulmonary Hypertension by Inhibiting cGAS/STING Mediated Cell Senescence [PDF]

Drug Design, Development and Therapy
Rongzhen Ding,1– 3 Haiping Xie,4 Yu Zhang,2,3 Li Qin,3,5 Guoran Peng,2,3 Jian Yi,2,3 Junlan Tan,6 Xianya Cao,2,3 Runxiu Zheng,2,3 Aiguo Dai2 1Department of Health Management, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan ...
Ding R, Xie H, Zhang Y, Qin L, Peng G, Yi J, Tan J, Cao X, Zheng R, Dai A   +9 more
doaj   +2 more sources

Simultaneous quantification of ginsenoside Rg1 and its metabolites by HPLC–MS/MS: Rg1 excretion in rat bile, urine and feces

Acta Pharmaceutica Sinica B, 2016
Ginsenoside Rg1 (Rg1), the major effective component of ginseng, has been shown to have multiple bioactivities, but low oral bioavailability. The aim of this study was to develop a simple, sensitive and rapid high performance liquid chromatography–tandem
Shifeng Chu, Min Huang
exaly   +3 more sources

Inhibition of caspase-1 by ginsenoside Rg1 ameliorates d-gal-induced renal aging and injury through suppression of oxidative stress and inflammation [PDF]

Renal Failure
Background The disruption of renal cell homeostasis caused by aging has attracted considerable attention. A traditional Chinese medicine, ginseng, is a potential drug for treating aging-related diseases. The study investigates the effect and mechanism of
Tingting Guo, Ting Xie, Xuejun Chen, Jingying Zhong, Zhenyu Bai, Huiyu Liang, Xiaoshan Zhao, Meixia Fang, Ya Xiao, Jun Zhang   +9 more
doaj   +2 more sources

Protective role of ginsenoside Rg1 in the dynamic progression of liver injury to fibrosis: a preclinical meta-analysis [PDF]

Frontiers in Pharmacology
BackgroundThe pathological progression from liver injury to fibrosis is a hallmark of liver disease, with no effective strategies to halt this transition.
Lijuan Dan, Xiuyan Li, Shuanglan Chen, Xiaojie You, Dong Wang, Tianyuan Wang, Jia Li, Wenping Liu, Jie Mu, Quansheng Feng, Quansheng Feng   +10 more
doaj   +2 more sources