Results 11 to 20 of about 8,086 (216)

Simultaneous quantification of ginsenoside Rg1 and its metabolites by HPLC–MS/MS: Rg1 excretion in rat bile, urine and feces

Acta Pharmaceutica Sinica B, 2016
Ginsenoside Rg1 (Rg1), the major effective component of ginseng, has been shown to have multiple bioactivities, but low oral bioavailability. The aim of this study was to develop a simple, sensitive and rapid high performance liquid chromatography–tandem
Chiyu He, Ru Feng, Yupeng Sun, Shifeng Chu, Ji Chen, Chao Ma, Jie Fu, Zhenxiong Zhao, Min Huang, Jiawen Shou, Xiaoyang Li, Yuzhu Wang, Jinfeng Hu, Yan Wang, Juntian Zhang   +14 more
doaj   +3 more sources

New Therapeutic Approaches to and Mechanisms of Ginsenoside Rg1 against Neurological Diseases

Cells, 2022
Neurological diseases, including Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), stroke, cerebral infarction, ischemia-reperfusion injury, depression and, stress, have high incidence and morbidity and often lead to ...
Yang Sun, Yantao Yang, Shasha Liu, Songwei Yang, Chen Chen, Meiyu Lin, Qi Zeng, Junpeng Long, Jiao Yao, Fan Yi, Lei Meng, Qidi Ai, Naihong Chen   +12 more
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Ginsenoside Rg1 exerts anti-arrhythmic effect by inhibiting I through cAMP-PKA and PI3K-AKT signaling pathways in rat ventricular myocytes after myocardial ischemia-reperfusion injury [PDF]

Science Progress
Objective Ginsenoside Rg1 has demonstrated beneficial effects in myocardial ischemia-reperfusion (I/R) injury. However, its potential anti-arrhythmic role in ventricular arrhythmias remains unclear.
Teng Wang, Hongyi Zhao, Yuting Chen, Sheng Guo, Chengzhi Zhou, Hong Cao, Qiang Zou, Qingxiu Wang   +7 more
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Ginsenoside Rg1 can reverse fatigue behavior in CFS rats by regulating EGFR and affecting Taurine and Mannose 6-phosphate metabolism

Frontiers in Pharmacology, 2023
Background: Chronic fatigue syndrome (CFS) is characterized by significant and persistent fatigue. Ginseng is a traditional anti-fatigue Chinese medicine with a long history in Asia, as demonstrated by clinical and experimental studies.
Chaofang Lei, Jiaxu Chen, Jiaxu Chen, Zhen Huang, Yinian Men, Yue Qian, Mingzhi Yu, Xinyi Xu, Lin Li, Xin Zhao, Youming Jiang, Yueyun Liu   +11 more
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Ginsenoside Rg1 ameliorates Alzheimer's disease pathology via restoring mitophagy

Journal of Ginseng Research, 2023
Alzheimer's disease (AD) is a common form of dementia, and impaired mitophagy is a hallmark of AD. Mitophagy is mitochondrial-specific autophagy. Ginsenosides from Ginseng involve in autophagy in cancer. Ginsenoside Rg1 (Rg1 hereafter), a single compound of Ginseng, has neuroprotective effects on AD.
Ni Wang, Junyan Yang, Ruijun Chen, Yunyun Liu, Shunjie Liu, Yining Pan, Qingfeng Lei, Yuzhou Wang, Lu He, Youqiang Song, Zhong Li   +10 more
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Ginsenoside Rg1 inhibits nucleus pulposus cell apoptosis, inflammation and extracellular matrix degradation via the YAP1/TAZ pathway in rats with intervertebral disc degeneration

Journal of Orthopaedic Surgery and Research, 2022
Purpose Intervertebral disc degeneration (IDD) is one of the main causes of low back pain, which not only affects patients’ life quality, but also places a great burden on the public health system.
Yong-hua Yang, Xiao-peng Gu, Hong Hu, Bin Hu, Xiang-lian Wan, Zhi-ping Gu, Shao-jin Zhong   +6 more
doaj   +1 more source

Ginsenosides are novel naturally-occurring aryl hydrocarbon receptor ligands. [PDF]

, 2013
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that mediates many of the biological and toxicological actions of structurally diverse chemicals.
Bonati, Laura, Denison, Michael S, Fraccalvieri, Domenico, He, Guochun, Hu, Qin, Soshilov, Anatoly, Xie, Qunhui, Yin, Huijun, Zhang, Aiqian, Zhao, Bin, Zhao, Jing   +10 more
core   +6 more sources

Ginsenoside Rg1 as a promising adjuvant agent for enhancing the anti-cancer functions of granulocytes inhibited by noradrenaline

Frontiers in Immunology, 2023
IntroductionIn recent years, numerous studies have confirmed that chronic stress is closely related to the development of cancer. Our previous research showed that high levels of stress hormones secreted in the body during chronic stress could inhibit ...
Yuqian Zhu, Jingyao Chen, Jun Li, Chenqi Zhou, Xin Huang, Bingdi Chen   +5 more
doaj   +1 more source

Ginsenoside Rg1 promotes endothelial progenitor cell migration and proliferation [PDF]

Acta Pharmacologica Sinica, 2009
To investigate the effect of ginsenoside Rg1 on the migration, adhesion, proliferation, and VEGF expression of endothelial progenitor cells (EPCs).EPCs were isolated from human peripheral blood and incubated with different concentrations of ginsenoside Rg1 (0.1, 0.5, 1.0, and 5.0 micromol/L) and vehicle controls.
Ai-wu, Shi, Xiao-bin, Wang, Feng-xiang, Lu, Min-min, Zhu, Xiang-qing, Kong, Ke-jiang, Cao   +5 more
openaire   +2 more sources

Host miR-129-5p reverses effects of ginsenoside Rg1 on morphine reward possibly mediated by changes in B. vulgatus and serotonin metabolism in hippocampus

Gut Microbes, 2023
Morphine addiction is closely associated with dysbiosis of the gut microbiota. miRNAs play a crucial role in regulating intestinal bacterial growth and are involved in the development of disease.
Chan Li, Yingbo Lin, Rukun Lin, Zhijie Chen, Qichun Zhou, Chaohua Luo, Zhixian Mo   +6 more
doaj   +1 more source