Results 21 to 30 of about 6,513 (215)

Ginsenoside Rg1: A Neuroprotective Natural Dammarane-Type Triterpenoid Saponin With Anti-Depressive Properties. [PDF]

CNS Neurosci Ther
Depression, a widespread mental disorder, presents significant risks to both physical and mental health due to its high rates of recurrence and suicide.
Han D, Zhao Z, Mao T, Gao M, Yang X, Gao Y.   +5 more
europepmc   +2 more sources

Ginsenoside Rg1 ameliorates hypoxia-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition and inflammation by regulating CCN1.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023
Pulmonary arterial hypertension (PAH) is a chronic obstructive disease characterized by vascular remodeling. Studies have confirmed that ginsenoside Rg1 can improve pulmonary hypertension to a certain extent, but the potential mechanism by which it ...
Bai-lin Tang, Yu Liu, Jingling Zhang, Meili Lu, Hong-Xin Wang   +4 more
semanticscholar   +1 more source

Ginsenoside Rg1 ameliorated experimental colitis by regulating the balance of M1/M2 macrophage polarization and the homeostasis of intestinal flora.

European Journal of Pharmacology, 2022
Aberrant M1/M2 macrophage polarization and dysbiosis are involved in the pathogenesis of ulcerative colitis (UC). Ginsenoside Rg1 exhibits optimal immunomodulatory and anti-inflammatory effects in treating UC of humans and animals, but the action ...
Jian-fei Long, Xue-Ke Liu, Zengping Kang, Mengxue Wang, Haimei Zhao, Jia-Qi Huang, Qiuping Xiao, Duanyong Liu, Youbao Zhong   +8 more
semanticscholar   +1 more source

Host miR-129-5p reverses effects of ginsenoside Rg1 on morphine reward possibly mediated by changes in B. vulgatus and serotonin metabolism in hippocampus

Gut Microbes, 2023
Morphine addiction is closely associated with dysbiosis of the gut microbiota. miRNAs play a crucial role in regulating intestinal bacterial growth and are involved in the development of disease.
Chan Li, Yingbo Lin, Rukun Lin, Zhijie Chen, Qichun Zhou, Chaohua Luo, Zhixian Mo   +6 more
doaj   +1 more source

New Therapeutic Approaches to and Mechanisms of Ginsenoside Rg1 against Neurological Diseases

Cells, 2022
Neurological diseases, including Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), stroke, cerebral infarction, ischemia-reperfusion injury, depression and, stress, have high incidence and morbidity and often lead to ...
Yang Sun, Yantao Yang, Shasha Liu, Songwei Yang, Chen Chen, Mei-yu Lin, Qi Zeng, Junpeng Long, Jiao Yao, Fan Yi, Lei Meng, Qidi Ai, Naihong Chen   +12 more
semanticscholar   +1 more source

Ginsenoside Rg1 Reduced Microglial Activation and Mitochondrial Dysfunction to Alleviate Depression-Like Behaviour Via the GAS5/EZH2/SOCS3/NRF2 Axis

Molecular Neurobiology, 2022
Ginsenoside Rg1 is the principal active ingredient in ginseng. The antidepressant effects of Rg1 have been validated; however, the specific underlying mechanism of this effect needs further research.
Junnan Li, Wei Gao, Zhonghui Zhao, Yannan Li, Lixuan Yang, Wei Wei, Feifei Ren, Yang Li, Yao Yu, Wenzhe Duan, Jingchun Li, Baoan Dai, Rongjuan Guo   +12 more
semanticscholar   +1 more source

Protective effect of ginsenoside Rg1 on attenuating anti-GBM glomerular nephritis by activating NRF2 signalling

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Background/Aim Ginsenoside Rg1 exerts a beneficial effect in many kidney diseases. But little work has been done to confirm whether ginsenoside Rg1 could also exert a protective effect on anti-glomerular basement membrane (anti-GBM) glomerular nephritis (
Xiaojuan Guo, Jingyuan Zhang, Min Liu, Guo Chen Zhao   +3 more
doaj   +1 more source

Ginsenoside Rg1 as a Potential Regulator of Hematopoietic Stem/Progenitor Cells [PDF]

Stem Cells International, 2021
Ginsenoside Rg1 (Rg1), a purified, active component of the root or stem of ginseng, exerts positive effects on mesenchymal stem cells (MSCs). Many recent studies have found that hematopoietic stem cells (HSCs), which can develop into hematopoietic progenitor cells (HPCs) and mature blood cells, are another class of heterogeneous adult stem cells that ...
Fang He, Guanping Yao
openaire   +3 more sources

Ginsenoside Rg1 prevents cognitive impairment and hippocampus senescence in a rat model of D-galactose-induced aging. [PDF]

PLoS ONE, 2014
Neurogenesis continues throughout the lifetime in the hippocampus, while the rate declines with brain aging. It has been hypothesized that reduced neurogenesis may contribute to age-related cognitive impairment. Ginsenoside Rg1 is an active ingredient of
Jiahong Zhu, Xinyi Mu, Jin Zeng, Chunyan Xu, Jun Liu, Mengsi Zhang, Chengpeng Li, Jie Chen, Tinyu Li, Yaping Wang   +9 more
doaj   +1 more source

Activities of β-Glucosidase and α-L-Arabinofuranosidase from Cordyceps militaris and Their Applications in the Transformation of Ginsenoside Rg1 and Rc [PDF]

Shipin Kexue, 2023
In this study, a strain of Cordyceps militaris with high productivity of β-glucosidase was identified and selected. The effects of carbon source, nitrogen source and pH value on the production of β-glucosidase, α-L-arabinofuranosidase, cordyceps acid and
LI Fei, HUANG Qiuting, SUI Xin, XIE Ying
doaj   +1 more source