Results 141 to 150 of about 5,453 (156)

Ginsenoside Rb1 Directly Scavenges Hydroxyl Radical and Hypochlorous Acid

Current Pharmaceutical Design, 2012
Reactive oxygen species (ROS) have been implicated in a variety of inflammatory diseases including cardiovascular disease (CVD), cancer, diabetes, Alzheimer's disease, autism, cataracts and aging. When endogenous mechanisms for the maintenance of redox homeostasis are overwhelmed, dietary intake of antioxidants contributes substantially to balancing ...
Jian-Ming, Lü, Sarah M, Weakley, Zhen, Yang, Ming, Hu, Qizhi, Yao, Changyi, Chen   +5 more
openaire   +2 more sources

Ginsenoside Rb1: The new treatment measure of myasthenia gravis

International Immunopharmacology, 2016
Myasthenia gravis (MG) is an autoimmune neuromuscular disease characterized by fatigue and muscle weakness. Ginseng is used in the treatment of MG. Ginsenoside Rb1 (G-Rb1), the most abundant ginsenoside in ginseng root, has been proved to be immune regulatory in various diseases.
Wei, Chen, Qing-Fang, Meng, Jun-Kang, Sui, Yan-Jun, Wang, Xiao-Li, Li, Shen, Liu, Heng, Li, Cong-Cong, Wang, Chun-Hong, Li, Yan-Bin, Li   +9 more
openaire   +2 more sources

Conversion of major ginsenoside Rb1 to 20(S)-ginsenoside Rg3 by Microbacterium sp. GS514

Phytochemistry, 2008
Ginseng saponin, the most important secondary metabolite in ginseng, has various pharmacological activities. Many studies have been directed towards converting major ginsenosides to the more active minor ginsenoside, Rg3. Due to the difficulty in preparing ginsenoside Rg3 enzymatically, the compound has been mainly produced by either acid treatment or ...
Le-Qin, Cheng, Ju Ryun, Na, Myun Ho, Bang, Myung Kyum, Kim, Deok-Chun, Yang   +4 more
openaire   +2 more sources

Ginsenoside Rb1 ameliorates apical periodontitis via suppressing macrophage pyroptosis

Oral Diseases
AbstractObjectivesThe objectives of current study were to investigate the role and related mechanism of Ginsenoside Rb1 (GRb1) on regulating apical periodontitis (AP) prognosis.Materials and MethodsClinical specimens were used to determine the involvement of calcium overload‐induced macrophage pyroptosis in periapical tissues.
Xiaoyue Guan, Rui Zhao, Yuting Wang, Wenlan Li, Lifei Pan, Yao Yang, Wenli Mu, Tie Zhou Hou   +7 more
openaire   +2 more sources

[Advance of pharmacological study on ginsenoside Rb1].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009
Ginsenoside Rb1 is a representative component of panaxadiol saponins, which belongs to dammarane-type tritepenoid saponins and mainly exists in family araliaceae. It has been reported that ginsenoside Rb1 has diverse biological activities. In this paper, the research development in recent decade on its pharmacological effects of cardiovascular system ...
Ji-ming, Jia, Zong-quan, Wang, Li-jun, Wu, Yi-ling, Wu   +3 more
openaire   +1 more source

Anti-inflammatory and anti-gouty-arthritic effect of free Ginsenoside Rb1 and nano Ginsenoside Rb1 against MSU induced gouty arthritis in experimental animals

Chemico-Biological Interactions, 2020
Ginsenoside Rb1 (GsRb1) is the best constituent of ginseng and although it shows clinical efficacy as an antineoplastic, antioxidative and antirheumatic agent, its oral bioavailability is poor due to its limited solubility. In this study, the solubility of GsRb1 was improved by encapsulating it in polymeric nanocapsules (encapsulation efficiency: 99.79%
Yuan, Liu, Haiyang, Zhu, Wei, Zhou, Qing, Ye   +3 more
openaire   +2 more sources

High efficiency production of ginsenoside compound K by catalyzing ginsenoside Rb1 using snailase

Chinese Journal of Chemical Engineering, 2018
Abstract The rare ginsenoside Compound K (C-K) is attracting more attention because of its good physiological activity and urgent need. There are many pathways to obtain ginsenoside C-K, including chemical and biological methods. Among these, the conversion of PPD-type ginsenosides by enzymatic hydrolysis is a trend due to its high efficiency and ...
Zhiguang Duan, Chenhui Zhu, Jingjing Shi, Daidi Fan, Jianjun Deng, Rongzhan Fu, Rong Huang, Cuiying Fan   +7 more
openaire   +1 more source

Biotransformation of ginsenoside Rb1 to ginsenoside Rd by highly substrate-tolerant Paecilomyces bainier 229-7

Bioresource Technology, 2010
Paecilomyces bainier 229-7 was obtained after UV irradiation for 8 min in the presence of 0.4% LiCl and selection on potato dextrose media containing 30 mg/mL saponin from Panax notoginseng leaves (SPNL). The mutant produces ginsenoside Rd from ginsenoside Rb1 with a bioconversion rate as high as 94.9% under optimized culture conditions in shake flasks
Li, Ye, Chao-Qun, Zhou, Wei, Zhou, Pei, Zhou, Dao-Feng, Chen, Xiao-Hui, Liu, Xun-Long, Shi, Mei-Qing, Feng   +7 more
openaire   +2 more sources

[Immunodetection of ginsenoside Rb1 in rat serum].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2010
To establish a novel immunoassay for qualitative detection of ginsenoside Rb1 in rat serum.Anti-G-Rb1 monoclonal antibody (mAb) was through a hybridoma approach. Rat serum containing G-Rb1 was deproteinized with methanol to prepare the sample for testing, which was loaded onto polyethersulfone (PES) membrane and developed in the mixture of acetonitrile,
Li-ling, Ma, Zhi, Chao, Hiroyuki, Tanaka, Yukihiro, Shoyama   +3 more
openaire   +1 more source

Effects of Ginsenoside Rb1 on Skin Changes

2012
Ginseng roots (Panax ginseng CA Meyer) have been used traditionally for the treatment, especially prevention, of various diseases in China, Korea, and Japan. Both experimental and clinical studies suggest ginseng roots to have pharmacological effects in patients with life-style-related diseases such as non-insulin-dependent diabetic mellitus ...
openaire   +1 more source