Results 141 to 150 of about 5,735 (170)

Pharmacokinetic Study of Ginsenosides Rb1 and Rg1 in Rat by ELISA Using Anti-ginsenosides Rb1 and Rg1 Monoclonal Antibodies

The American Journal of Chinese Medicine, 2006
Enzyme-linked immunosorbent assay (ELISA) systems using anti-ginsenoside Rb1 (G-Rb1) and Rg1 (G-Rg1) monoclonal antibodies (MAbs) were established for pharmacokinetic investigations of G-Rb1 and G-Rg1 in rat serum. The systems not only allowed sensitive detection of G-Rb1 at the level as low as 20 ng/ml and of G-Rg1 at 300 ng/ml, but showed strong ...
Zhi, Chao, Yukihiro, Shoyama, Hiroyuki, Tanaka   +2 more
openaire   +2 more sources

Biotransformation of ginsenoside Rb1 and Rd to four rare ginsenosides and evaluation of their anti-melanogenic effects

Journal of Natural Medicines, 2023
Improving physiological activity of primary ginsenosides through biotransformation is of great significance for food applications. In this study, gynostapenoside XVII, gynostapenoside LXXV, ginsenoside F2, and ginsenoside CK were obtained by enzymolysis of an accessible extract composed of ginsenoside Rb1 and Rd.
Le Zhang, Liwei Wang, Yufei Chen, Yaya Yang, Guohua Xia, Yuao Guo, Huan Yang, Yuping Shen, Anne S. Meyer   +8 more
openaire   +2 more sources

Ginsenoside Rb1 improves cardiac function and remodeling in heart failure

Experimental Animals, 2017
We investigated the effect of ginsenoside Rb1 on cardiac function and remodeling in heart failure (HF). Four weeks after HF induction, the rats were administrated with ginsenoside Rb1 (35 and 70 mg/kg) and losartan (4.5 mg/kg) for 8 weeks. Losartan was used as a positive control.
Zheng, Xian, Wang, Shuai, Zou, Xiaoming, Jing, Yating, Yang, Ronglai, Li, Siqi, Wang, Fengrong   +6 more
exaly   +4 more sources

Ginsenoside Rb1 and Rg3 Attenuate Glucocorticoid-Induced Neurotoxicity

Cellular and Molecular Neurobiology, 2010
Glucocorticoid (GC) hormones, increased in response to stress, can cause neuronal loss. We tested the effect of GC hormone on cell viability of neural SHSY-5Y cells and protective effects of ginsenoside Rb1 and Rg3 on the action of GC. We treated SHSY-5Y cells with increasing concentrations of synthetic GC dexamethasone (DEX; 10, 25, 50, and 100 nM ...
Sung-Ok, Kim, Jung-Man, You, Su-Jin, Yun, Min-Sook, Son, Kyong Nyon, Nam, Joung-Woo, Hong, Sun Yeou, Kim, Sang Yoon, Choi, Eunjoo H, Lee   +8 more
openaire   +2 more sources

Ginsenoside Rb1: The new treatment measure of myasthenia gravis

International Immunopharmacology, 2016
Myasthenia gravis (MG) is an autoimmune neuromuscular disease characterized by fatigue and muscle weakness. Ginseng is used in the treatment of MG. Ginsenoside Rb1 (G-Rb1), the most abundant ginsenoside in ginseng root, has been proved to be immune regulatory in various diseases.
Wei, Chen, Qing-Fang, Meng, Jun-Kang, Sui, Yan-Jun, Wang, Xiao-Li, Li, Shen, Liu, Heng, Li, Cong-Cong, Wang, Chun-Hong, Li, Yan-Bin, Li   +9 more
openaire   +2 more sources

Ginsenoside Rb1 Suppresses AOM/DSS-induced Colon Carcinogenesis

Anti-Cancer Agents in Medicinal Chemistry, 2023
Background: Colorectal cancer (CRC) is the third most common cancer worldwide. Current treatments, including surgery, radiotherapy, and chemotherapy, are limited by severe side effects and the development of resistance. Objective: Therefore, it is important to find additional therapies to combat the problem.
Ling, Wang, Qing-Qing, Zhang, Yu-Yu, Xu, Rui, Zhang, Qing, Zhao, Yu-Qing, Zhang, Xue-Hong, Huang, Bin, Jiang, Min, Ni   +8 more
openaire   +2 more sources

Conversion of major ginsenoside Rb1 to 20(S)-ginsenoside Rg3 by Microbacterium sp. GS514

Phytochemistry, 2008
Ginseng saponin, the most important secondary metabolite in ginseng, has various pharmacological activities. Many studies have been directed towards converting major ginsenosides to the more active minor ginsenoside, Rg3. Due to the difficulty in preparing ginsenoside Rg3 enzymatically, the compound has been mainly produced by either acid treatment or ...
Le-Qin, Cheng, Ju Ryun, Na, Myun Ho, Bang, Myung Kyum, Kim, Deok-Chun, Yang   +4 more
exaly   +3 more sources

A one-step immunochromatographic assay for detecting ginsenosides Rb1 and Rg1

Analytical and Bioanalytical Chemistry, 2004
An immunochromatographic strip test has been developed for detecting ginsenosides Rb1 (G-Rb1) and Rg1 (G-Rg1). This qualitative assay system is useful as a rapid screening method for detecting G-Rb1 and G-Rg1 in plants and plant preparations. Our assay is a competitive immunoassay that uses anti-G-Rb1 and anti-G-Rg1 monoclonal antibodies (MAbs) and a ...
Waraporn, Putalun, Noriko, Fukuda, Hiroyuki, Tanaka, Yukihiro, Shoyama   +3 more
openaire   +2 more sources

Neuroprotective effects of ginsenoside Rb1 on transient cerebral ischemia in rats

Brain Research, 2007
Previous experiments showed that ginsenoside Rb1 (GRb1) reduced infarct and neuronal deficit in rats followed by transient cerebral ischemia. The mechanism of this neuroprotective function is unclear. Here, we tested whether the effect of GRb1 can be achieved through preventing ischemic neuronal death, modulating apoptotic-related genes and affecting ...
Q-L, Yuan, C-X, Yang, P, Xu, X-Q, Gao, L, Deng, P, Chen, Z-L, Sun, Q-Y, Chen   +7 more
openaire   +2 more sources

[Advance of pharmacological study on ginsenoside Rb1].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009
Ginsenoside Rb1 is a representative component of panaxadiol saponins, which belongs to dammarane-type tritepenoid saponins and mainly exists in family araliaceae. It has been reported that ginsenoside Rb1 has diverse biological activities. In this paper, the research development in recent decade on its pharmacological effects of cardiovascular system ...
Ji-ming, Jia, Zong-quan, Wang, Li-jun, Wu, Yi-ling, Wu   +3 more
openaire   +1 more source