Results 101 to 110 of about 6,472 (203)

Ginsenoside Rg1 activates ligand-independent estrogenic effects via rapid estrogen receptor signaling pathway

Journal of Ginseng Research, 2019
Background: Ginsenoside Rg1 was shown to exert ligand-independent activation of estrogen receptor (ER) via mitogen-activated protein kinase–mediated pathway.
Quan-Gui Gao, Li-Ping Zhou, Vien Hoi-Yi Lee, Hoi-Yi Chan, Cornelia Wing-Yin Man, Man-Sau Wong   +5 more
doaj   +1 more source

Ginsenoside Rg1 Ameliorates Cigarette Smoke-Induced Airway Fibrosis by Suppressing the TGF-β1/Smad Pathway In Vivo and In Vitro [PDF]

, 2017
Small airway fibrosis is a key pathological process accompanying chronic obstructive pulmonary disease (COPD) and includes fibroblast/myofibroblast transdifferentiation and excessive extracellular matrix deposition.
Lin Song, Sibin Guan, Fengfeng Han, Wen Gu, Xuejun Guo, Weiguo Xu, Qian Liu, Yue Zhang   +7 more
core   +1 more source

Antidepressant-like Effects of Ginsenoside Rg1 in the Chronic Restraint Stress-induced Rat Model

Digital Chinese Medicine, 2019
Objective: To investigate the ameliorating effect of ginsenoside Rg1 on the depression-like behaviors induced by chronic restraint stress (CRS) in rats and the underlying mechanisms. Methods: Forty male Wistar rats were divided into 4 groups according to
Jiang Ning, Lv Jing-Wei, Wang Hai-Xia, Huang Hong, Wang Qiong, Chen Shan-Guang, Qu Li-Na, Alberto Carlos Pires Dias, Liu Xin-Min   +8 more
doaj   +1 more source

Ginsenoside RG1 and corticosteroid receptors in rat brain [PDF]

, 1987
Old (28 months) male Wistar rats were treated chronically for two weeks with ginsenoside Rg1 or with vehicle delivered via sc implanted Alzet mini-pumps (rate of ginsenoside release 2.4 micrograms/0.5 microliter/h).
Tonnaer, J A, de Kloet, E R, Reul, J M, van den Bosch, F R, Saito, H   +4 more
core  

Ginsenoside Rg1 activates AMPK to inhibit lipid deposition in a cell model of non-alcoholic fatty liver disease

Di-san junyi daxue xuebao, 2019
Objective To investigate the effect of ginsenoside Rg1 on lipid deposition in a cell model of non-alcoholic fatty liver disease (NAFLD) and explore the molecular mechanism.
XIAO Qing, HUANG Wenxiang, ZHANG Shujun, YANG Cheng, LI Jiajun   +4 more
doaj   +1 more source

Ginsenoside Rg1 promotes browning by inducing UCP1 expression and mitochondrial activity in 3T3-L1 and subcutaneous white adipocytes

Journal of Ginseng Research, 2019
Background: Panax ginseng Meyer is known as a conventional herbal medicine, and ginsenoside Rg1, a steroid glycoside, is one of its components. Although Rg1 has been proved to have an antiobesity effect, the mechanism of this effect and whether it ...
Kippeum Lee, Young-Jin Seo, Ji-Hyoen Song, Sungwoo Chei, Boo-Yong Lee   +4 more
doaj   +1 more source

Mechanism of Ginsenoside Rg1 in Regulating the Metabolic Function of Intestinal Flora for the Treatment of High-Purine Dietary Hyperuricemia [PDF]

Objective: Study the mechanism of ginsenoside Rg1 in ameliorating hyperuricemia (HUA) induced by high-purine diet. Methods: Rats were randomly divided into groups, and the HUA model was established by administering a high-purine diet containing potassium
Qiang Sun, Yang Yu, Yinshi Sun, Zhiman Li   +3 more
core   +1 more source

Ginsenoside Rg1 from Panax ginseng enhances myoblast differentiation and myotube growth [PDF]

, 2017
Background: Ginsenoside Rg1 belongs to protopanaxatriol-type ginsenosides and has diverse pharmacological activities. In this report, we investigated whether Rg1 could upregulate muscular stem cell differentiation and muscle growth.
Sang-Jin Lee, Si-Kwan Kim, Jaecheol Lee, Jong-Sun Kang, Ayoung Jo, Su-Nam Kim, Gyu-Un Bae, Yong Kee Kim, Ga-Yeon Go, Dong-Wan Seo   +9 more
core   +1 more source

Artificial cell derived vesicles from Ginsenoside Rg1-primed mesenchymal stromal cells mitigate oxidative stress and DNA damage in myocardial ischemic/reperfusion injury

Nano Research
Myocardial ischemia/reperfusion injury (MI/RI) remains a major challenge in the treatment of acute myocardial infarction due to the lack of effective therapeutic options. While mesenchymal stromal cells (MSCs) and their derivates show promising potential
Shuang Zhao, Huilan Fan, Shuxiang Yang, Chengyan Xu, Yanli Liu, Yixuan Guo, Yangyi Yu, Yafei Sun, Haijing Li, Yong Wang, Jincheng Guo, Chun Li, Jingyu Wang   +12 more
doaj   +1 more source

Mass Production of Rg1-Loaded Small Extracellular Vesicles Using a 3D Bioreactor System for Enhanced Cardioprotective Efficacy of Doxorubicin-Induced Cardiotoxicity

Pharmaceutics
Background: Small extracellular vesicles (sEVs) obtained from human umbilical cord mesenchymal stromal cells (MSCs) have shown cardioprotective efficacy in doxorubicin-induced cardiotoxicity (DIC).
Yunfeng Di, Shuang Zhao, Huilan Fan, Wei Li, Guangjian Jiang, Yong Wang, Chun Li, Wei Wang, Jingyu Wang   +8 more
doaj   +1 more source