Results 81 to 90 of about 6,513 (215)

Ginsenoside protects intestinal barrier function and improves epithelium injury in sepsis by regulating the miR-30e-5p/FBXO11 axis

Electronic Journal of Biotechnology, 2023
Background: Ginsenoside Rg1 has been studied to improve systemic inflammatory injury induced by sepsis, but its mechanism is not fully understood. The objective of this study was to explore the potential molecular mechanism by which Rg1 ameliorates ...
Wenqian Zhu, Dingjun Fan, Zhu Zhou, Yimei Wang, Xiang Huang, Liwen Zhang, Di Wu, Yi Ren, Fei Lu, Xikun Gao   +9 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, Volume 7, Issue 2, Page 52-66, June 2026.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Enzymatic transglycosylation of ginsenoside Rg1 by rice seed α-glucosidase [PDF]

Bioscience, Biotechnology, and Biochemistry, 2016
Abstract Six α-monoglucosyl derivatives of ginsenoside Rg1 (G-Rg1) were synthesized by transglycosylation reaction of rice seed α-glucosidase in the reaction mixture containing maltose as a glucosyl donor and G-Rg1 as an acceptor. Their chemical structures were identified by spectroscopic analysis, and the effects of reaction time, pH ...
Min-Ji, Kim, Young-Hoi, Kim, Geun-Sup, Song, Yukio, Suzuki, Myung-Kon, Kim   +4 more
openaire   +2 more sources

Ginsenoside Rg1 promoted the wound healing in diabetic foot ulcers via miR-489-3p/Sirt1 axis.

Journal of Pharmacological Sciences, 2021
PURPOSE Diabetic foot ulcers (DFUs) are common complications of high severity for diabetes. Ginsenoside Rg1 (Rg1) has the potential for diabetes and cardiovascular diseases therapy. This research aimed at exploring the regulation of Rg1 on DFUs treatment
Liang Huang, Hua-An Cai, Ming-sheng Zhang, Ruo-Yi Liao, Xinxin Huang, Feng-dan Hu   +5 more
semanticscholar   +1 more source

Ginsenoside Rg1 Improves Differentiation by Inhibiting Senescence of Human Bone Marrow Mesenchymal Stem Cell via GSK-3β and β-Catenin

Stem Cells International, 2020
Objectives. To demonstrate the effect of Ginsenoside Rg1 on the differentiation of human bone marrow-derived mesenchymal stem cells (hBM-MSCs).
Ziling Wang, Rong Jiang, Lu Wang, Xiongbin Chen, Yue Xiang, Linbo Chen, Minghe Xiao, Li Ling, Yaping Wang   +8 more
doaj   +1 more source

Korean Red Ginseng Attenuates Dysfunctions and Modulates Inflammatory and Neuroplasticity Markers in the Harmaline‐Induced Model of Essential Tremor

Brain and Behavior, Volume 16, Issue 6, June 2026.
Korean red Ginseng significantly reduces tremor severity, improves motor coordination, and ameliorates anxiety and cognitive deficits in a mouse model of essential tremor through suppression of neuroinflammatory markers and normalization of neuroplasticity genes in the cerebellum.
Monavareh Soti, Mehran Ilaghi, Leila Bagherzadeh, Fatemeh Shahsavari, Kristi A. Kohlmeier, Zeynab Pirmoradi, Mohammad Shabani   +6 more
wiley   +1 more source

Ginsenoside Rg1 Epigenetically Modulates Smad7 Expression in Liver Fibrosis via MicroRNA-152

Journal of Ginseng Research, 2022
Background Ginsenoside Rg1, a bioactive component of Ginseng, has demonstrated anti-inflammatory, anti-cancer, and hepatoprotective effects. It is known that the epithelial–mesenchymal transition (EMT) plays a key role in the activation of hepatic ...
Rongrong Zhang, Xinmiao Li, Yuxiang Gao, Qiqiang Tao, Zhichao Lang, Yating Zhan, Chunxue Li, Jianjian Zheng   +7 more
semanticscholar   +1 more source

Screening and Evaluation of Anti-aging Activity of Ginsenosides Based on Saccharomyces cerevisiae System

Shipin gongye ke-ji, 2022
Saccharomyces cerevisiae was used as a model organism to screen the anti-aging activity of ginsenosides and explore its activities. The optimal concentration of ginsenoside was screened out based on the growth curve of the model strain Saccharomyces ...
Jingjing CHEN, Xueyuan BAI, Shuai BIAN, Shiyu JI, Siming WANG   +4 more
doaj   +1 more source

Structural Characterization of Ginseng Adventitious Root Polysaccharides and Their Effects on Ameliorating Insulin Resistance

eFood, Volume 7, Issue 3, June 2026.
Purified ginseng adventitious root polysaccharides (GARP) improve insulin resistance by enhancing glucose and lipid metabolism and reducing oxidative stress. These beneficial effects are mediated, at least in part, through activation of the Nrf2/Keap1 signaling pathway in cellular and animal models.
Tian‐fu Yang, Ting‐ting Hu, Xiao‐di Zhuang, Yi‐lun Zhou, Xin Qi, Cheng‐bi Cui   +5 more
wiley   +1 more source

Protective effect of ginsenoside Rg1 on glutamate-induced lung injury [PDF]

Acta Pharmacologica Sinica, 2007
To examine the possible protective effect of ginsenoside Rg1, an active component of ginseng, on lung injury caused by glutamate in vivo.The lungs of mice receiving glutamate (0.5 g/kg) and/or ginsenoside Rg1 (0.03 g/kg) via intraperitoneal administration were collected.
Li, Shen, Jian-Zhong, Han, Chen, Li, Shao-Jie, Yue, Yong, Liu, Xiao-Qun, Qin, Hui-Jun, Liu, Zi-Qiang, Luo   +7 more
openaire   +2 more sources