Results 91 to 100 of about 6,472 (203)

Encephalopathy: Cause, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 6, June 2026.
Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv, Xia Zhong, Ruirui Shang, Linghui Kong, Yufei Huang, Yuexiang Ma, Jing Teng, Sheng Wei   +7 more
wiley   +1 more source

Modulation of G protein α-subunit mRNA levels in discrete rat brain regions by cerebroventricular infusion of ginsenoside Rc and Rg1 [PDF]

, 2018
We have investigated the effects of centrally administered ginsenoside Rc and Rg1 on the modulation of G protein expression in the central nervous system in rat brain.
오세관
core   +1 more source

Contrasting actions of ginsenosides Rb1 and Rg1 on glucose tolerance in rats

Chinese Journal of Physiology, 2019
Ginsenoside profile of Panax ginseng is changing with season and cultivated soil. Yet, dose-response relationship of main ginsenosides on metabolic measures has not been documented in vivo. Here, we examined glucose and insulin responses after an oral glucose challenge (0.5 g/kg body weight) at various doses (0.01, 0.1, 1, and 10 mg/kg of body weight ...
Rungchai Chaunchaiyakul, Naruemon Leelayuwat, Jin-Fu Wu, Chih-Yang Huang, Chia-Hua Kuo   +4 more
openaire   +3 more sources

Chromosome‐Level Genome Assembly of the Allotetraploid Gynostemma pentaphyllum Provides Novel Insights Into the Biosynthesis of Ginsenoside and Gypenoside LVI

Plant Biotechnology Journal, Volume 24, Issue 6, Page 4204-4220, June 2026.
ABSTRACT Gynostemma pentaphyllum, a herb used in tea and traditional Chinese medicine, shows geographic variation in its production of valuable dammarane‐type ginsenosides and gypenoside LVI between populations from Suining (SN) and Nanning (NN). To elucidate the mechanisms underlying this differential metabolite accumulation, a chromosome‐level genome
Peina Zhou, Si‐Jie Liu, Lijin Huang, Yingping Wang, Xinyu Jiang, Wang Dong, Jianfeng Gong, Long Wang, Yuyin Zhao, Huiying Wang, Ping Li, Jia‐Yu Xue, Xu Lu   +12 more
wiley   +1 more source

Regulated Cell Death in Idiopathic Pulmonary Fibrosis

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
This graphical abstract illustrates regulated cell death (RCD) across key pulmonary cell types—including alveolar epithelial cells, fibroblasts, macrophages, and endothelial cells—modulated through a dynamic death modulation network within the IPF microenvironment.
Xiaoyue Pan, Liu Yang, Man Zhao, Yanlin Zhou, Cong Xia, Huibing Liu, Yuqi Wang, Hui Lian, Bin Li, Lan Wang, Guoying Yu   +10 more
wiley   +1 more source

Effects of ginsenoside Rg1 on the senescence of vascular smooth muscle cells

Genetics and Molecular Research, 2016
The development of age-related cardiovascular disease is associated with the senescence of vascular cells. This study aimed to investigate the effect of ginsenoside Rg1 on vascular smooth muscle cell (VSMC) senescence. Primary VSMCs were cultured and divided into control, D-galactose (D-gal), Rg1-L, and Rg1-H groups, which were cultured without and ...
S G, Li, M Z, Yan, D, Zhang, M, Ye, J J, Deng   +4 more
openaire   +2 more sources

Characterization of Chondrogenic Gene Expression and Cartilage Phenotype Differentiation in Human Breast Adipose-Derived Stem Cells Promoted by Ginsenoside Rg1 In Vitro

Cellular Physiology and Biochemistry, 2015
Background/Aims: Investigating and understanding chondrogenic gene expression during the differentiation of human breast adipose-derived stem cells (HBASCs) into chondrogenic cells is a prerequisite for the application of this approach for cartilage ...
Fang-Tian Xu, Hong-Mian Li, Cheng-Yi Zhao, Zhi-Jie Liang, Min-Hong Huang, Qing Li, Ying-Chao Chen, Gang-Yi Chi   +7 more
doaj   +1 more source

Antidepressant-like effects of Rg1 by mycn: promotion of neurogenesis in the hippocampus

Frontiers in Pharmacology
Ginsenoside Rg1 has been shown to have antidepressant effects by increasing hippocampal neurogenesis, but the molecular mechanisms remain unclear. In this research, we showed that Rg1 has antidepressant-like effects by increasing neurogenesis in the ...
Enze Shi, Yiwei Zhang, Yanyan Fan, Jiangfan Chen, Linfeng Xu, Jiao Chen   +5 more
doaj   +1 more source

Ginsenoside Rg1 improves ischemic brain injury by balancing mitochondrial biogenesis and mitophagy [PDF]

, 2017
Purpose: To study the effects of ginsenoside Rg1 on mitochondrial dysfunction  induced by ischemic stroke.Methods: Human neuroblastoma SK-N-SH cells, subjected to oxygen-glucose  deprivation (OGD), were divided into six groups: control group, OGD group ...
Chen, Ningnan, Long, Xiangling, Tang, Xuhui   +2 more
core   +2 more sources

Molecular signaling of ginsenosides Rb1, Rg1, and Rg3 and their mode of actions

Journal of Ginseng Research, 2018
Ginseng has gained its popularity as an adaptogen since ancient days because of its triterpenoid saponins, known as ginsenosides. These triterpenoid saponins are unique and classified as protopanaxatriol and protopanaxadiol saponins based on their glycosylation patterns.
Padmanaban Mohanan, Sathiyamoorthy Subramaniyam, Ramya Mathiyalagan, Deok-Chun Yang   +3 more
openaire   +3 more sources