Results 71 to 80 of about 6,031 (176)

Effects of ginsenoside Rg1 on the senescence of vascular smooth muscle cells

Genetics and Molecular Research, 2016
The development of age-related cardiovascular disease is associated with the senescence of vascular cells. This study aimed to investigate the effect of ginsenoside Rg1 on vascular smooth muscle cell (VSMC) senescence. Primary VSMCs were cultured and divided into control, D-galactose (D-gal), Rg1-L, and Rg1-H groups, which were cultured without and ...
S G, Li, M Z, Yan, D, Zhang, M, Ye, J J, Deng   +4 more
openaire   +2 more sources

Antidepressant-like effects of Rg1 by mycn: promotion of neurogenesis in the hippocampus

Frontiers in Pharmacology
Ginsenoside Rg1 has been shown to have antidepressant effects by increasing hippocampal neurogenesis, but the molecular mechanisms remain unclear. In this research, we showed that Rg1 has antidepressant-like effects by increasing neurogenesis in the ...
Enze Shi, Yiwei Zhang, Yanyan Fan, Jiangfan Chen, Linfeng Xu, Jiao Chen   +5 more
doaj   +1 more source

Characterization of Chondrogenic Gene Expression and Cartilage Phenotype Differentiation in Human Breast Adipose-Derived Stem Cells Promoted by Ginsenoside Rg1 In Vitro

Cellular Physiology and Biochemistry, 2015
Background/Aims: Investigating and understanding chondrogenic gene expression during the differentiation of human breast adipose-derived stem cells (HBASCs) into chondrogenic cells is a prerequisite for the application of this approach for cartilage ...
Fang-Tian Xu, Hong-Mian Li, Cheng-Yi Zhao, Zhi-Jie Liang, Min-Hong Huang, Qing Li, Ying-Chao Chen, Gang-Yi Chi   +7 more
doaj   +1 more source

Ginsenoside Rg1 activates ligand-independent estrogenic effects via rapid estrogen receptor signaling pathway

Journal of Ginseng Research, 2019
Background: Ginsenoside Rg1 was shown to exert ligand-independent activation of estrogen receptor (ER) via mitogen-activated protein kinase–mediated pathway.
Quan-Gui Gao, Li-Ping Zhou, Vien Hoi-Yi Lee, Hoi-Yi Chan, Cornelia Wing-Yin Man, Man-Sau Wong   +5 more
doaj   +1 more source

Molecular signaling of ginsenosides Rb1, Rg1, and Rg3 and their mode of actions

Journal of Ginseng Research, 2018
Ginseng has gained its popularity as an adaptogen since ancient days because of its triterpenoid saponins, known as ginsenosides. These triterpenoid saponins are unique and classified as protopanaxatriol and protopanaxadiol saponins based on their glycosylation patterns.
Padmanaban Mohanan, Sathiyamoorthy Subramaniyam, Ramya Mathiyalagan, Deok-Chun Yang   +3 more
openaire   +3 more sources

Antidepressant-like Effects of Ginsenoside Rg1 in the Chronic Restraint Stress-induced Rat Model

Digital Chinese Medicine, 2019
Objective: To investigate the ameliorating effect of ginsenoside Rg1 on the depression-like behaviors induced by chronic restraint stress (CRS) in rats and the underlying mechanisms. Methods: Forty male Wistar rats were divided into 4 groups according to
Jiang Ning, Lv Jing-Wei, Wang Hai-Xia, Huang Hong, Wang Qiong, Chen Shan-Guang, Qu Li-Na, Alberto Carlos Pires Dias, Liu Xin-Min   +8 more
doaj   +1 more source

Ginsenoside Rg1 activates AMPK to inhibit lipid deposition in a cell model of non-alcoholic fatty liver disease

Di-san junyi daxue xuebao, 2019
Objective To investigate the effect of ginsenoside Rg1 on lipid deposition in a cell model of non-alcoholic fatty liver disease (NAFLD) and explore the molecular mechanism.
XIAO Qing, HUANG Wenxiang, ZHANG Shujun, YANG Cheng, LI Jiajun   +4 more
doaj   +1 more source

Inhibition of caspase-1 by ginsenoside Rg1 ameliorates d-gal-induced renal aging and injury through suppression of oxidative stress and inflammation

Renal Failure
Background The disruption of renal cell homeostasis caused by aging has attracted considerable attention. A traditional Chinese medicine, ginseng, is a potential drug for treating aging-related diseases. The study investigates the effect and mechanism of
Tingting Guo, Ting Xie, Xuejun Chen, Jingying Zhong, Zhenyu Bai, Huiyu Liang, Xiaoshan Zhao, Meixia Fang, Ya Xiao, Jun Zhang   +9 more
doaj   +1 more source

Ginsenoside Rg1 promotes browning by inducing UCP1 expression and mitochondrial activity in 3T3-L1 and subcutaneous white adipocytes

Journal of Ginseng Research, 2019
Background: Panax ginseng Meyer is known as a conventional herbal medicine, and ginsenoside Rg1, a steroid glycoside, is one of its components. Although Rg1 has been proved to have an antiobesity effect, the mechanism of this effect and whether it ...
Kippeum Lee, Young-Jin Seo, Ji-Hyoen Song, Sungwoo Chei, Boo-Yong Lee   +4 more
doaj   +1 more source

Artificial cell derived vesicles from Ginsenoside Rg1-primed mesenchymal stromal cells mitigate oxidative stress and DNA damage in myocardial ischemic/reperfusion injury

Nano Research
Myocardial ischemia/reperfusion injury (MI/RI) remains a major challenge in the treatment of acute myocardial infarction due to the lack of effective therapeutic options. While mesenchymal stromal cells (MSCs) and their derivates show promising potential
Shuang Zhao, Huilan Fan, Shuxiang Yang, Chengyan Xu, Yanli Liu, Yixuan Guo, Yangyi Yu, Yafei Sun, Haijing Li, Yong Wang, Jincheng Guo, Chun Li, Jingyu Wang   +12 more
doaj   +1 more source