Results 51 to 60 of about 6,031 (176)

Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

Advanced Science, Volume 13, Issue 51, 14 September 2026.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang   +13 more
wiley   +1 more source

Ginsenoside Rg1 Prevents Chronic Stress-Induced Depression-Like Behaviors and Neuronal Structural Plasticity in Rats

Cellular Physiology and Biochemistry, 2018
Background/Aims: Ginsenoside Rg1 has been demonstrated to exhibit neuroprotective effects in various studies. This study aimed to investigate the neuronal mechanisms underlying the neuroprotective and antidepressant-like effects of ginsenoside Rg1 in a ...
Hongluan Yu, Cuiqin Fan, Lejin Yang, Shuyan Yu, Qiqi Song, Peng Wang, Xueqin Mao   +6 more
doaj   +1 more source

Osteogenic Activity of New Dammarane‐Type Saponins From Gynostemma pentaphyllum

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Isolation and determination of two new and three known dammarane‐type glycosides from the aerial parts of Gynostemma pentaphyllum with their osteogenic activity via stimulation of alkaline phosphatase (ALP) activity, collagen synthesis, and calcium mineralization in mouse osteoblastic MC3T3‐E1 cells.
Nguyen Tuan Duong, Tran Thi Thu Ha, Duong Thi Hai Yen, Do Thi Thao, Bui Huu Tai, Phan Van Kiem   +5 more
wiley   +1 more source

Radioimmunoassay for the determination of ginseng saponin, ginsenoside RG1.

Chemical and Pharmaceutical Bulletin, 1982
Radioimmunoassay method for the determination of ginsenoside Rg1, one of the major saponins of Panax ginseng root, was established. The side chain of ginsenoside Rg1 was modified and coupled to BSA. 125I-Labelled compound of ginsenoside Rg1 was prepared from a ginsenoside Rg1-tyramine conjugate.
Sankawa, Ushio, Sung, Chung Ki, Han, Byung Hoon, Akiyama, Toshiyuki, Kawashima, Koichiro   +4 more
openaire   +2 more sources

Ginsenoside Rg1 Improves Differentiation by Inhibiting Senescence of Human Bone Marrow Mesenchymal Stem Cell via GSK-3β and β-Catenin

Stem Cells International, 2020
Objectives. To demonstrate the effect of Ginsenoside Rg1 on the differentiation of human bone marrow-derived mesenchymal stem cells (hBM-MSCs).
Ziling Wang, Rong Jiang, Lu Wang, Xiongbin Chen, Yue Xiang, Linbo Chen, Minghe Xiao, Li Ling, Yaping Wang   +8 more
doaj   +1 more source

Natural Product‐Derived Vesicles in Nanotherapeutics

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
Natural product‐derived vesicles (NPVs) are an emerging nature‐based nanotherapeutic that can deliver bioactive metabolites into the target site and induce beneficial mechanisms. A practical, chronological bench‐to‐bedside approach throughout the entire NPV development process is expected to resolve challenges encountered in NPV studies.
Kartiko Arif Purnomo, Tsong‐Long Hwang
wiley   +1 more source

Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives

Precision Medical Sciences, Volume 15, Issue 3, Page 206-226, September 2026.
Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley   +1 more source

Protective effect of ginsenoside Rg1 on glutamate-induced lung injury [PDF]

Acta Pharmacologica Sinica, 2007
To examine the possible protective effect of ginsenoside Rg1, an active component of ginseng, on lung injury caused by glutamate in vivo.The lungs of mice receiving glutamate (0.5 g/kg) and/or ginsenoside Rg1 (0.03 g/kg) via intraperitoneal administration were collected.
Li, Shen, Jian-Zhong, Han, Chen, Li, Shao-Jie, Yue, Yong, Liu, Xiao-Qun, Qin, Hui-Jun, Liu, Zi-Qiang, Luo   +7 more
openaire   +2 more sources

Molecular descriptor driven QSPR modeling of Papp, TEER and Efflux Ratio from Caco‐2 cells using machine learning for various phytochemicals

Journal of the Science of Food and Agriculture, Volume 106, Issue 11, Page 6606-6616, 30 August 2026.
Abstract BACKGROUND The present study aimed to develop and validate quantitative structure–property relationship (QSPR) models for predicting permeability related bioavailability indicators including apparent permeability (Papp), trans‐epithelial electrical resistance (TEER) and efflux ratio (ER) based on molecular descriptors (n = 5003) of 83 ...
Jin‐Woo Kim, Rixing Cong, Jin‐Soo Park, Keunwan Park, Kyungsu Kang, Soon‐Mi Shim   +5 more
wiley   +1 more source

Gut Microbiota and Ischemic Stroke: From Pre‐Stroke Dysbiosis and Acute‐Phase Changes to Therapeutic Applications

Brain and Behavior, Volume 16, Issue 8, August 2026.
Abstract Purpose Ischemic stroke poses a major global health burden, and growing evidence points to the microbiota–gut–brain axis as an important contributor to stroke pathophysiology and recovery. The purpose of this review is to summarize current knowledge on bidirectional gut‐brain communication in stroke, establishing gut dysbiosis as an upstream ...
Ruihui Weng, Gaolei Dong, Jianxin Tang, Yu Zhao   +3 more
wiley   +1 more source