Results 161 to 170 of about 6,472 (203)

Ginsenoside Rg1 Prevents Doxorubicin-Induced Cardiotoxicity through the Inhibition of Autophagy and Endoplasmic Reticulum Stress in Mice [PDF]

open access: yesInternational Journal of Molecular Sciences, 2018
Ginsenoside Rg1, a saponin that is a primary component of ginseng, has been demonstrated to protect hearts from diverse cardiovascular diseases with regulating multiple cellular signal pathways.
Zhimeng Xu, Ping Li
exaly   +2 more sources
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Ginsenoside Rg1 and ginsenoside Rh1 prevent liver injury induced by acetaminophen in mice

Journal of Food Biochemistry, 2021
With the development of technology, drugs are being developed for different purposes. Thus, the rate of drug injury considerably increased worldwide. Liver is the largest detoxification organ in the human body, but it is also the organ most vulnerable to drug damage.
Yunfeng Bi   +5 more
openaire   +2 more sources

Ginsenoside Rg1 in neurological diseases: From bench to bedside

Acta Pharmacologica Sinica, 2022
Ginseng has been used in China as a superior medicinal material for thousands of years that can nourish the five internal organs, calm the mind and benefit wisdom. Due to its anti-inflammatory, antioxidant and neuroprotective activities, one of the active components of ginseng, ginsenoside Rg1, has been extensively investigated in the remedy of brain ...
Shao-Jie, Yang   +5 more
openaire   +2 more sources

New Therapeutic Approaches to and Mechanisms of Ginsenoside Rg1 against Neurological Diseases [PDF]

open access: yesCells, 2022
Neurological diseases, including Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), stroke, cerebral infarction, ischemia-reperfusion injury, depression and, stress, have high incidence and morbidity and often lead to ...
Nai-Hong Chen, Qidi Ai, Fan Yi
exaly   +2 more sources

Pharmacokinetic Study of Ginsenosides Rb1 and Rg1 in Rat by ELISA Using Anti-ginsenosides Rb1 and Rg1 Monoclonal Antibodies

The American Journal of Chinese Medicine, 2006
Enzyme-linked immunosorbent assay (ELISA) systems using anti-ginsenoside Rb1 (G-Rb1) and Rg1 (G-Rg1) monoclonal antibodies (MAbs) were established for pharmacokinetic investigations of G-Rb1 and G-Rg1 in rat serum. The systems not only allowed sensitive detection of G-Rb1 at the level as low as 20 ng/ml and of G-Rg1 at 300 ng/ml, but showed strong ...
Zhi, Chao   +2 more
openaire   +2 more sources

Ginsenoside Rg1 prevent and treat inflammatory diseases: A review

International Immunopharmacology, 2020
Ginseng has been used as reinforcing drugs or for traditional Chinese medicine in aging, inflammation, stress, diabetes mellitus, hepatic diseases and cancer. The aim of this current review is to provide an integrative overview of the uses, relative human diseases and related mechanisms of ginseng.
Yan, Gao   +8 more
openaire   +2 more sources

Biotransformation of ginsenosides Re and Rg1 into ginsenosides Rg2 and Rh1 by recombinant β-glucosidase

Biotechnology Letters, 2012
Ginsenosides Re and Rg1 were transformed by recombinant β-glucosidase (Bgp1) to ginsenosides Rg2 and Rh1, respectively. The bgp1 gene consists of 2,496 bp encoding 831 amino acids which have homology to the glycosyl hydrolase families 3 protein domain.
Lin-Hu, Quan   +5 more
openaire   +2 more sources

Ginsenoside Rg1 promotes proliferation of hippocampal progenitor cells

Neurological Research, 2004
Neural progenitor cells (NPCs) exist not only in the developing brain, but also in certain areas in adult brain in mammals. Recent studies suggest that promoting neurogenesis in adult mammals might provide a therapeutic way to cure age-related neurodegenerative diseases.
Li-Hong, Shen, Jun-Tian, Zhang
openaire   +2 more sources

Neuroprotective Effects and Brain Transport of Ginsenoside Rg1

Chinese Journal of Natural Medicines, 2009
Aim Ginsenoside Rg1, one of the major ingredients of Panax notoginseng saponins (PNS), has been proven to possess protective effects on the central nerve system (CNS). However, whether ginsenoside Rg1 could efficiently be transported through the blood brain barrier to elicit its neuroprotective effects remains still unclear. The present study was thus
Rui WANG   +5 more
openaire   +2 more sources

Chondroprotective Effects of Ginsenoside Rg1 in  Human Osteoarthritis Chondrocytes and a Rat Model  of Anterior Cruciate Ligament Transection [PDF]

open access: yesNutrients, 2017
This study aimed to assess whether Ginsenoside Rg1 (Rg1) inhibits inflammatory responses in human chondrocytes and reduces articular cartilage damage in a rat model of osteoarthritis (OA). Gene expression and protein levels of type II collagen, aggrecan,
Wendan Cheng   +2 more
exaly   +2 more sources

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