Results 181 to 190 of about 6,513 (215)

Ginsenoside Rg1 Suppresses Pyroptosis via the NF-κB/NLRP3/GSDMD Pathway to Alleviate Chronic Atrophic Gastritis In Vitro and In Vivo.

Journal of Agricultural and Food Chemistry
Chronic atrophic gastritis (CAG) is characterized by the loss of gastric glandular cells, which are replaced by the intestinal-type epithelium and fibrous tissue. Ginsenoside Rg1 (Rg1) is the prevalent ginsenoside in ginseng, with a variety of biological
Zehua Zhou, Cheng Hu, Bo Cui, Lisha You, Rui An, Kun Liang, Xinhong Wang   +6 more
semanticscholar   +1 more source

Metabolism of ginsenoside Rg1 by intestinal bacteria. II. Immunological activity of ginsenoside Rg1 and Rh1.

Acta pharmacologica Sinica, 2001
To compare the effect of ginsenoside Rg1 and its metabolite Rh1 on proinflammatory cytokines and their mRNA expression by THP-1 cells.Human peripheral blood mononuclear cells (PBMC) were incubated with Rg1 and Rh1 at concentrations of 0.1, 1, 10, and 100 mg/L, and the cell proliferation was measured 24 h after incubation.
Y, Wang, B X, Wang, T H, Liu, M, Minami, T, Nagata, T, Ikejima   +5 more
openaire   +1 more source

[Pharmacokinetics and bioavailability of ginsenoside Rg1 in rats].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2014
To investigate the pharmacokinetics and bioavailability of ginsenoside Rg1 in rats.Ginsenoside Rg1 was oral administered or intravenous administered to each rat. The plasma concentration of ginsenoside Rg1 was estimated by RP-HPLC. 3P97 software was used to calculate pharmacokinetic parameters.Main parameters of ginsenoside Rg1 after oral or ...
Zhen-Yuan, Tan, Wang-Na, Xiong, Xing-Zhen, Huang, Jian-Qin, Liang   +3 more
openaire   +1 more source

Ginsenoside-Rg1 protects podocytes from complement mediated injury

Journal of Ethnopharmacology, 2011
Podocytes injury mediated by complement complex C5b-9 is the main feature of membranous nephropathy (MN). Little work has been done to prove that ginsenoside-Rg1 could inhibit this process. Our study aims to investigate the efficacy of ginsenoside-Rg1 in protecting the podocyte from complement mediated injury.We chose sublethal C5b-9 induced podocyte ...
Ming-Hua, Zhang, Jun-Ming, Fan, Xi-Sheng, Xie, Yue-Yi, Deng, Yi-Pin, Chen, Rong, Zhen, Jing, Li, Yuan, Cheng, Ji, Wen   +8 more
openaire   +2 more sources

A one-step immunochromatographic assay for detecting ginsenosides Rb1 and Rg1

Analytical and Bioanalytical Chemistry, 2004
An immunochromatographic strip test has been developed for detecting ginsenosides Rb1 (G-Rb1) and Rg1 (G-Rg1). This qualitative assay system is useful as a rapid screening method for detecting G-Rb1 and G-Rg1 in plants and plant preparations. Our assay is a competitive immunoassay that uses anti-G-Rb1 and anti-G-Rg1 monoclonal antibodies (MAbs) and a ...
Waraporn, Putalun, Noriko, Fukuda, Hiroyuki, Tanaka, Yukihiro, Shoyama   +3 more
openaire   +2 more sources

Ginsenoside Rg1 inhibits the TSLP production in allergic rhinitis mice

Immunopharmacology and Immunotoxicology, 2013
Recent study reports that Korean red ginseng reduces the nasal allergic inflammatory reaction in an allergic murine model. However, the contribution of ginsenoside Rg1 (RG1) and its mechanisms on allergic rhinitis (AR) have not been elucidated. In this study, we evaluated the important activities of RG1 in the ovalbumin (OVA)-induced AR mice.
Hyun-A, Oh, Ji-Young, Seo, Hyun-Ja, Jeong, Hyung-Min, Kim   +3 more
openaire   +2 more sources

Ginsenoside Rg1 attenuates cardiomyocyte apoptosis and inflammation via the TLR4/NF‐kB/NLRP3 pathway

Journal of Cellular Biochemistry, 2019
Sepsis‐induced myocardial dysfunction (SIMD) causes high mortality in seriously ill patients. Ginsenoside Rg1 has been proven to have effective anti‐inflammatory and antiapoptotic properties.
Man Luo, Dongsheng Yan, Qingsong Sun, Jia-Li Tao, Liang Xu, Hong Sun, Hongmei Zhao   +6 more
semanticscholar   +1 more source

[Immunoregulatory effects of ginsenoside Rg1 in aged rats].

Yao xue xue bao = Acta pharmaceutica Sinica, 1996
It has been well documented that the immune function declines with age in the human and animals. The possible causes for the decline are the inability of lymphocytes to proliferate in response to mitogenic stimulation and the decrease of IL-2 production.
M, Liu, J T, Zhang
openaire   +1 more source

Pharmacokinetics, tissue distribution, metabolism, and excretion of ginsenoside Rg1 in rats

Archives of Pharmacal Research, 2010
The pharmacokinetics, tissue distribution, metabolism, and excretion of ginsenosides Rg(1) were studied in Wistar rats, by measuring the concentrations of Rg(1) and its metabolites in the blood, tissues, bile, urine, and feces after dosing. After intravenous (i.v.) administration, the elimination half-lives of Rg(1) and its metabolites were 1.82, 5.87,
Liang, Feng, Ling, Wang, Changjiang, Hu, Xuehua, Jiang   +3 more
openaire   +2 more sources

Absorption profiles of sanchinoside R1 and ginsenoside Rg1 in the rat intestine

European Journal of Drug Metabolism and Pharmacokinetics, 2005
Panax notoginseng is used as a therapeutic agent in Chinese medicine for stopping hemorrhage and also as a general health remedy. Although Panax notoginseng saponins (PNS) are currently attracting attention due to their hemorheological properties, the absorption profiles of PNS have still not been fully investigated.
Feng, Liang, Jiang Xue, Hua
openaire   +2 more sources