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Ginsenoside Rg1 in neurological diseases: From bench to bedside
Acta Pharmacologica Sinica, 2022Ginseng has been used in China as a superior medicinal material for thousands of years that can nourish the five internal organs, calm the mind and benefit wisdom. Due to its anti-inflammatory, antioxidant and neuroprotective activities, one of the active components of ginseng, ginsenoside Rg1, has been extensively investigated in the remedy of brain ...
Shao-Jie, Yang +5 more
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Hepataprotective effects of ginsenoside Rg1 – A review
Journal of Ethnopharmacology, 2017Ginseng has been used as efficient tonic and for the treatment of various diseases including hepatic disorders. Ginseng saponins, also known as ginsenosides, are principal constituents and have been treated to be responsible for disparate ginseng health benefits. The current review mainly focuses on ginsenoside Rg1, a compound isolated from traditional
Yan, Gao +3 more
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Ginsenoside-Rg1 protects podocytes from complement mediated injury
Journal of Ethnopharmacology, 2011Podocytes injury mediated by complement complex C5b-9 is the main feature of membranous nephropathy (MN). Little work has been done to prove that ginsenoside-Rg1 could inhibit this process. Our study aims to investigate the efficacy of ginsenoside-Rg1 in protecting the podocyte from complement mediated injury.We chose sublethal C5b-9 induced podocyte ...
Ming-Hua, Zhang +8 more
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Ginsenoside Rg1 prevent and treat inflammatory diseases: A review
International Immunopharmacology, 2020Ginseng has been used as reinforcing drugs or for traditional Chinese medicine in aging, inflammation, stress, diabetes mellitus, hepatic diseases and cancer. The aim of this current review is to provide an integrative overview of the uses, relative human diseases and related mechanisms of ginseng.
Yan, Gao +8 more
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Ginsenoside Rg1 promotes proliferation of hippocampal progenitor cells
Neurological Research, 2004Neural progenitor cells (NPCs) exist not only in the developing brain, but also in certain areas in adult brain in mammals. Recent studies suggest that promoting neurogenesis in adult mammals might provide a therapeutic way to cure age-related neurodegenerative diseases.
Li-Hong, Shen, Jun-Tian, Zhang
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Ginsenoside Rg1 inhibits platelet activation and arterial thrombosis
Thrombosis Research, 2014Derived from the root of Panax ginseng C.A.Mey, Panax notoginsenosides (PNS) is a widely used herbal medicine to treat atherothrombotic diseases in Asian medicine. Ginsenoside Rg1 is one of the main compounds responsible for the pharmaceutical actions of PNS.
Qi, Zhou +9 more
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The American Journal of Chinese Medicine, 2006
Enzyme-linked immunosorbent assay (ELISA) systems using anti-ginsenoside Rb1 (G-Rb1) and Rg1 (G-Rg1) monoclonal antibodies (MAbs) were established for pharmacokinetic investigations of G-Rb1 and G-Rg1 in rat serum. The systems not only allowed sensitive detection of G-Rb1 at the level as low as 20 ng/ml and of G-Rg1 at 300 ng/ml, but showed strong ...
Zhi, Chao +2 more
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Enzyme-linked immunosorbent assay (ELISA) systems using anti-ginsenoside Rb1 (G-Rb1) and Rg1 (G-Rg1) monoclonal antibodies (MAbs) were established for pharmacokinetic investigations of G-Rb1 and G-Rg1 in rat serum. The systems not only allowed sensitive detection of G-Rb1 at the level as low as 20 ng/ml and of G-Rg1 at 300 ng/ml, but showed strong ...
Zhi, Chao +2 more
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Neuroprotective Effects and Brain Transport of Ginsenoside Rg1
Chinese Journal of Natural Medicines, 2009Aim Ginsenoside Rg1, one of the major ingredients of Panax notoginseng saponins (PNS), has been proven to possess protective effects on the central nerve system (CNS). However, whether ginsenoside Rg1 could efficiently be transported through the blood brain barrier to elicit its neuroprotective effects remains still unclear. The present study was thus
Rui WANG +5 more
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Preparations of ginsenoside Rg1 immunogen and125I-labeled antiğen
Journal of Radioanalytical and Nuclear Chemistry Articles, 1996This work began with the side chain of ginsenoside Rg1 which was acetylized with Ac2O-Pyr and oxidized by OsO4 and NaIO4 to give ginsenoside Rg1 aldehyde(2), which was further converted into an unsaturated ester(3) by Wittig-Horner reaction. The unsaturated ester(3) was treated with N2H4 and HNO2 to yield Rg1 azide(4) which was directly conjugated with
Mei Congbiao +3 more
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Modification and stability of ginsenoside Rg1 PEG
China Journal of Chinese Materia Medica, 2012OBJECTIVE To study the stability of ginsenoside Rg1 before and after being modified by PEG (PEG-Rg1) in isolated rat stomachs. METHOD SD rats, after 18 h of fasting, were randomly divided into the Rg1 group and the PEG-Rg1 group. Rg1 stomach perfusion fluid and PEG-Rg1 infusion fluid were accurately extracted and injected into their stomachs in vitro ...
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