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Multifunctional ginsenoside Rg3-based liposomes for glioma targeting therapy

Journal of Controlled Release, 2021
Liposomes have been widely used for targeted drug delivery. However, nonselective distribution, low blood-brain barrier penetration, and the disadvantages of cholesterol greatly limit the application of conventional liposomes in the treatment of brain tumors.
Ying, Zhu   +13 more
openaire   +4 more sources

Conversion of major ginsenoside Rb1 to 20(S)-ginsenoside Rg3 by Microbacterium sp. GS514

Phytochemistry, 2008
Ginseng saponin, the most important secondary metabolite in ginseng, has various pharmacological activities. Many studies have been directed towards converting major ginsenosides to the more active minor ginsenoside, Rg3. Due to the difficulty in preparing ginsenoside Rg3 enzymatically, the compound has been mainly produced by either acid treatment or ...
Le-Qin, Cheng   +4 more
openaire   +4 more sources

Ginsenoside Rg3 improves cyclophosphamide-induced immunocompetence in Balb/c mice

International Immunopharmacology, 2019
Ginsenoside Rg3 (Rg3), which comprises Panax ginseng, is commonly used to improve the immunocompetence of cancer patients undergoing chemotherapy. This study was designed to elucidate the immunoenhancement effects of Rg3 in immunosuppressed mice induced by cyclophosphamide (CTX) treatment.
Xiao, Liu   +6 more
openaire   +4 more sources

Insights into the antitumor mechanism of ginsenosides Rg3

Molecular Biology Reports, 2021
Panax ginseng, an ancient herb, belonging to Chinese traditional medicine, is an important herb that has a remarkable impact on various diseases. Ginsenoside Rg3, one of the most abundant ginsenosides, exerts significant functions in the prevention of various types of cancers with few side effects.
Zongyu Liu   +5 more
openaire   +2 more sources

Ginsenoside Rb1 and Rg3 Attenuate Glucocorticoid-Induced Neurotoxicity

Cellular and Molecular Neurobiology, 2010
Glucocorticoid (GC) hormones, increased in response to stress, can cause neuronal loss. We tested the effect of GC hormone on cell viability of neural SHSY-5Y cells and protective effects of ginsenoside Rb1 and Rg3 on the action of GC. We treated SHSY-5Y cells with increasing concentrations of synthetic GC dexamethasone (DEX; 10, 25, 50, and 100 nM ...
Sung-Ok, Kim   +8 more
openaire   +2 more sources

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