Journal of Ginseng Research, 2023 Background: Gintonin (GT), a Panax ginseng-derived lysophosphatidic acid receptor (LPAR) ligand, has positive effects in cultured or animal models for Parkinson's disease, Huntington's disease, and so on. However, the potential therapeutic value of GT in
Jong Hee Choi +4 more
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Inflammatory Mediation of Heat Stress-Induced Growth Deficits in Livestock and Its Potential Role as a Target for Nutritional Interventions: A Review [PDF]
, 2021 Heat stress is detrimental to well-being and growth performance in livestock, and systemic inflammation arising during chronic heat stress contributes to these poor outcomes.
Most, Micah S., Yates, Dustin T.
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Journal of Ginseng Research, 2022 Background: Gintonin-enriched fraction (GEF), a non-saponin fraction of ginseng, is a novel glycolipoprotein rich in hydrophobic amino acids. GEF has recently been shown to regulate lipid metabolism and browning in adipocytes; however, the mechanisms ...
Heegu Jin +3 more
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Neuroprotective Effects of a Traditional Multi-Herbal Medicine Kyung-Ok-Ko in an Animal Model of Parkinson's Disease: Inhibition of MAPKs and NF-κB Pathways and Activation of Keap1-Nrf2 Pathway [PDF]
, 2018 Kyung-Ok-Ko (KOK), a traditional multi-herbal medicine, has been widely used in Oriental medicine as a restorative that can enforce vitality of whole organs and as a medicine that can treat age-related symptoms including lack of vigor and weakened ...
Ik-Hyun Cho +8 more
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A Simple Method for the Preparation of Crude Gintonin from Ginseng Root, Stem, and Leaf [PDF]
Journal of Ginseng Research, 2011 Ginseng has been used as a general tonic agent to invigorate the human body as an adaptogenic agent. In a previous report, we have shown that ginseng contains a novel glycolipoprotein called gintonin. The main function of gintonin is to transiently enhance intracellular free Ca(2+) [Ca(2+)]i levels in animal cells.
Pyo, Mi Kyung +8 more
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Lysophosphatidic acid receptors (LPARs): potential targets for the treatment of neuropathic pain [PDF]
, 2016 Neuropathic pain can arise from lesions to peripheral or central nerve fibres leading to spontaneous action potential generation and a lowering of the nociceptive threshold. Clinically, neuropathic pain can manifest in many chronic disease states such as
O'Sullivan, Catherine +2 more
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Atypical formations of gintonin lysophosphatidic acids as new materials and their beneficial effects on degenerative diseases. [PDF]
J Ginseng ResFresh ginseng is prone to spoilage due to its high moisture content. For long-term storage, most fresh ginsengs are dried to white ginseng (WG) or steamed for hours at high temperature/pressure and dried to form Korean Red ginseng (KRG). They are further processed for ginseng products when subjected to hot water extraction/concentration under pressure.
Kim JH +10 more
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A pharmacokinetic study on red ginseng with furosemide in equine [PDF]
, 2023 Red ginseng (RG) is a popular ingredient in traditional Korean medicine that has various health benefits. It is commonly taken orally as a dietary supplement; however, its potential interactions with concomitantly administered drugs are unclear.
Ahram Kim +7 more
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How natural therapies can combat neoplastic disease by targeting key survival mechanisms and signaling pathways [PDF]
Plant extracts are increasingly becoming an answer to expensive, high-dose, synthesized chemotherapy, with milder side effects and easier accessibility. Many botanical plants contain active ingredients, such as terpenoids and alkaloids, which may combat ...
Barker, James +11 more
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Oxidative stress in DNA repeat expansion disorders: a focus on NRF2 signaling involvement [PDF]
, 2020 DNA repeat expansion disorders are a group of neuromuscular and neurodegenerative diseases that arise from the inheritance of long tracts of nucleotide repetitions, located in the regulatory region, introns, or inside the coding sequence of a gene ...
Bertini, Enrico Silvio +3 more
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