Results 31 to 40 of about 1,850 (127)
Experimental Physiology, EarlyView.Abstract Balance and gaze rely on the rapid and accurate detection and signalling of head movements by vestibular type I and type II hair cells. Signal transduction and transmission involve several types of ion channels, which are acquired progressively during hair cell differentiation and whose identity is known only in part.
Giulia Cheli +9 more
wiley +1 more source
GJB2 and GJB6 Mutations in Non-Syndromic Childhood Hearing Impairment in Ghana
Frontiers in Genetics, 2019 Our study aimed to investigate GJB2 (connexin 26) and GJB6 (connexin 30) mutations associated with non-syndromic childhood hearing impairment (HI) as well as the environmental causes of HI in Ghana. Medical reports of 1,104 students attending schools for
Samuel M. Adadey +8 more
doaj +1 more source
Clouston Syndrome: Report of a Jordanian Family with GJB6 Gene Mutation
Case Reports in Dermatological Medicine, 2023 Ectodermal dysplasias (ED) encompass a collection of conditions wherein the development of two or more structures derived from the ectoderm exhibits abnormal patterns.
Rand Murshidi, Heba Al-lala
doaj +1 more source
Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.Current Management & Limitations: Traditional auditory devices lack genetic curative potential and yield variable, non‐physiological hearing outcomes. OTOF gene therapy has shown promising clinical outcomes with dual‐AAV therapy. GJB2 gene therapy remains an emerging approach with significant translational challenges. Advances in vector design and cell‐
Jiahui Zhao, Mengzhao Xun, Yu Sun
wiley +1 more source
Molecular study of hearing loss in Minas Gerais, Brazil
Brazilian Journal of Otorhinolaryngology, 2020 Introduction: Deafness is the most frequent sensory deficit in humans. Incidence is estimated at 4:1000 births in Brazil. Specific programs for clinical care of patients with hearing loss are still scarce in Brazil and the issue is an important public ...
Raíssa de Oliveira Aquino Schüffner +6 more
doaj +1 more source
Yin Yang 1 Specifically Supports the Development of Olig2 Positive Cerebellar Astrocytes
Glia, Volume 74, Issue 8, August 2026.Cerebellar Olig2 positive astrocytes are most abundant in the cerebellar nuclei. Cerebellar astrocytes expressing Olig2 have unique gene expression profiles. Yin Yang 1 specifically supports the development of astrocytes expressing Olig2. Deletion of YY1 during development increases numbers of astrocytes expressing Olig2 but hinders their ...
Masoumeh Zarei‐Kheirabadi +9 more
wiley +1 more source
Etiology of early hearing loss in Brazilian children
Brazilian Journal of Otorhinolaryngology, 2022 Introduction: Hearing loss etiology depends on the population studied as well as on the ethnicity and the socio-economic condition of the analyzed region.
Marina Faistauer +6 more
doaj +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.ABSTRACT Background The molecular mechanisms underlying frailty are under intense investigation. Independent observational studies revealed various biological processes and biomarkers differentially expressed in frail individuals and after interventions.
Diego Marcos‐Perez +10 more
wiley +1 more source
Two Portuguese Cochlear Implanted Dizygotic Twins: A Case Report
Case Reports in Genetics, 2012 Individual’s hearing performance after cochlear implant (CI) is variable and depends on different factors such as etiology of deafness, age at implantation, and social/family hearing environment.
Joana Rita Chora +9 more
doaj +1 more source
ChildrenGJB2 mutations are the most common cause of autosomal-recessive non-syndromic sensorineural hearing loss (SNHL). The available evidence shows large phenotypic variability across different genotypes and allelic variants.
Leonardo Franz +11 more
doaj +1 more source