Aquaporin-4, Connexin-30, and Connexin-43 as Biomarkers for Decreased Objective Sleep Quality and/or Cognition Dysfunction in Patients With Chronic Insomnia Disorder [PDF]
Frontiers in Psychiatry, 2022 ObjectivesTo examine serum concentrations of aquaporin-4 (AQP4), connexin-30 (CX30), connexin-43 (CX43), and their correlations with cognitive function in the patients with chronic insomnia disorder (CID).MethodsWe enrolled 76 subjects with CID and 32 ...
Shuai Yang +8 more
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Connexin 30 deletion exacerbates cochlear senescence and age-related hearing loss [PDF]
Frontiers in Cell and Developmental Biology, 2022 Pathogenic mutations in the Gjb2 and Gjb6 genes, encoding connexin 26 (Cx26) and connexin 30 (Cx30), respectively, have been linked to the most frequent monogenic hearing impairment, nonsyndromic hearing loss, and deafness DFNB1.
Fabiola Paciello +10 more
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Upregulation of astroglial connexin 30 impairs hippocampal synaptic activity and recognition memory. [PDF]
PLoS Biology, 2023 Astrocytes crucially contribute to synaptic physiology and information processing. One of their key characteristics is to express high levels of connexins (Cxs), the gap junction-forming protein.
Eléonore Hardy +8 more
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Virally Mediated Connexin 26 Expression in Postnatal Scala Media Significantly and Transiently Preserves Hearing in Connexin 30 Null Mice [PDF]
Frontiers in Cell and Developmental Biology, 2022 Non-sensory cells in the sensory epithelium of the cochlea are connected extensively by gap junctions. Functionally null mutations in GJB6 (encoding Cx30) cause hearing loss in humans. In this study, we injected AAV1-CB7-Gjb2 into the scala media between
Li Zhang +16 more
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Divergence between Hemichannel and Gap Junction Permeabilities of Connexin 30 and 26 [PDF]
Life, 2023 Cx30 has been proposed to play physiological functions in the kidney and cochlea, and this has often been associated with its hemichannel role (deafness mutants frequently affecting hemichannels more than gap junctions), implicated in ATP release.
Ji Xu, Bruce J. Nicholson
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Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model [PDF]
Journal of Neuroinflammation, 2018 Background The first pathology observed in Parkinson’s disease (PD) is ‘dying back’ of striatal dopaminergic (DA) terminals. Connexin (Cx)30, an astrocytic gap junction protein, is upregulated in the striatum in PD, but its roles in neurodegeneration ...
Atsushi Fujita +6 more
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Impact of isoflurane anesthesia on astrocyte connexin 30 expression in adult rats and its possible implications for postoperative neurocognitive disorder [PDF]
European Journal of Medical ResearchObjective Postoperative neurocognitive disorders (NCD) are common complications following general anesthesia, yet their underlying mechanisms remain poorly understood.
Ming-Ying Li +5 more
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Connexin 30 Deficiency Attenuates Chronic but Not Acute Phases of Experimental Autoimmune Encephalomyelitis Through Induction of Neuroprotective Microglia [PDF]
Frontiers in Immunology, 2018 Glial connexins (Cxs) form gap junction channels through which a pan-glial network plays key roles in maintaining homeostasis of the central nervous system (CNS). In multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (
Mei Fang +8 more
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Corrigendum: Virally mediated connexin 26 expression in postnatal scala media significantly and transiently preserves hearing in connexin 30 null mice [PDF]
Frontiers in Cell and Developmental Biology, 2022 Li Zhang +16 more
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ATP Releasing Connexin 30 Hemichannels Mediate Flow-Induced Calcium Signaling in the Collecting Duct [PDF]
Frontiers in Physiology, 2013 ATP in the renal tubular fluid is an important regulator of salt and water reabsorption via purinergic calcium signaling that involves the P2Y2 receptor, ENaC and AQP2.
Per eSvenningsen +3 more
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