Impact of genetic counseling and Connexin-26 and Connexin-30 testing on deaf identity and comprehension of genetic test results in a sample of deaf adults: a prospective, longitudinal study. [PDF]
PLoS ONE, 2014 Using a prospective, longitudinal study design, this paper addresses the impact of genetic counseling and testing for deafness on deaf adults and the Deaf community.
Christina G S Palmer +3 more
doaj +3 more sources
Connexin 30 controls astroglial polarization during postnatal brain development.
Development, 2018 International audienceAstrocytes undergo intense morphological maturation during development, changing from individual sparsely branched cells to polarized and tremendously ramified cells.
Ghézali G +8 more
europepmc +2 more sources
Disease Models & Mechanisms, 2021 Connexin 30 (Cx30; also known as Gjb6 when referring to the mouse gene) is expressed in ependymal cells of the brain ventricles, in leptomeningeal cells and in astrocytes rich in connexin 43 (Cx43), leading us to question whether patients harboring GJB6 ...
Nicole M. Novielli-Kuntz +4 more
doaj +1 more source
Role of Impaired Astrocyte Gap Junction Coupling in Epileptogenesis
Cells, 2023 The gap-junction-coupled astroglial network plays a central role in the regulation of neuronal activity and synchronisation, but its involvement in the pathogenesis of neuronal diseases is not yet understood.
Peter Bedner, Christian Steinhäuser
doaj +1 more source
Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning
Cell Reports, 2022 Summary: The mechanisms by which astrocytes modulate neural homeostasis, synaptic plasticity, and memory are still poorly explored. Astrocytes form large intercellular networks by gap junction coupling, mainly composed of two gap junction channel ...
Ladina Hösli +14 more
doaj +1 more source
Dynamic changes in connexin expression correlate with key events in the wound healing process. [PDF]
, 2003 Wound healing is a complex process requiring communication for the precise co-ordination of different cell types. The role of extracellular communication through growth factors in the wound healing process has been extensively documented, but the role of
Kamaldeep Tamber +9 more
core +1 more source
CO2 directly modulates connexin 26 by formation of carbamate bridges between subunits [PDF]
, 2013 Homeostatic regulation of the partial pressure of CO2 (PCO2) is vital for life. Sensing of pH has been proposed as a sufficient proxy for determination of PCO2 and direct CO2-sensing largely discounted.
Greenhalgh, S.A. +18 more
core +1 more source
Experimental and Molecular Medicine, 2020 Hearing loss: Disruption at the junction A decrease in the levels of connexin proteins at the junctions connecting cells in the inner-ear precedes age-related hearing loss (ARHL) in mice.
Shori Tajima +3 more
doaj +1 more source
Connexin 30 expression and frequency of connexin heterogeneity in astrocyte gap junction plaques increase with age in the rat retina. [PDF]
PLoS ONE, 2013 We investigated age-associated changes in retinal astrocyte connexins (Cx) by assaying Cx numbers, plaque sizes, protein expression levels and heterogeneity of gap junctions utilizing six-marker immunohistochemistry (IHC).
Hussein Mansour +5 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2015 Astrocytes, the most prominent glial cell type in the brain, send specialized processes called endfeet, around blood vessels and express a large molecular repertoire regulating the cerebrovascular system physiology. One of the most striking properties of
Anne-Cécile eBoulay +7 more
doaj +1 more source