Results 41 to 50 of about 5,562,313 (185)

Intracellular Delivery of Short Interfering RNA in Rat Organ of Corti Using a Cell-penetrating Peptide PepFect6

Molecular Therapy: Nucleic Acids, 2012
RNA interference (RNAi) using short interfering RNA (siRNA) is an attractive therapeutic approach for treatment of dominant-negative mutations. Some rare missense dominant-negative mutations lead to congenital-hearing impairments.
Suvarna Dash-Wagh, Stefan Jacob, Staffan Lindberg, Anders Fridberger, Ülo Langel, Mats Ulfendahl   +5 more
doaj   +1 more source

Mechanisms of Diseases Associated with Mutation in GJC2/Connexin 47

Biomolecules, 2023
Connexins are members of a family of integral membrane proteins that provide a pathway for both electrical and metabolic coupling between cells. Astroglia express connexin 30 (Cx30)-GJB6 and Cx43-GJA1, while oligodendroglia express Cx29/Cx31.3-GJC3, Cx32-
Charles K. Abrams
doaj   +1 more source

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

Molecular and functional characterization of gap junctions in the avian inner ear. [PDF]

, 2006
To analyze the fundamental role of gap junctions in the vertebrate inner ear, we examined molecular and functional characteristics of gap junctional communication (GJC) in the auditory and vestibular system of the chicken.
Nickel, R, Becker, D, Forge, A
core  

Connexin 30 sets synaptic strength by controlling astroglial synapse invasion

, 2014
Astrocytes play active roles in brain physiology by dynamic interactions with neurons. Connexin 30, one of the two main astroglial gap-junction subunits, is thought to be involved in behavioral and basic cognitive processes.
Holcman, David, Benchenane, Karim, Dominik Freche, Ezan, P., Martine Cohen-Salmon, Escartin, C., Rouach, Nathalie, Ulrike Pannasch, Pannasch, U., Graham Knott, Carole Escartin, Knott, G., Dufour, A., Escartin, Carole, Ghézali, Grégory, Abudara, Veronica, Dallérac, Glenn, Veronica Abudara, Nicole Déglon, Abudara, V., Holcman, D., Ghézali, G., Lübke, J.H., Dallérac, G., Knott, Graham, Pascal Ezan, Dufour, Amandine, Nathalie Rouach, Joachim H R Lübke, David Holcman, Pannasch, Ulrike, Benchenane, K., Amandine Dufour, Ezan, Pascal, Grégory Ghézali, Lübke, Joachim, Freche, D., Déglon, N., Karim Benchenane, Rouach, N., Cohen-Salmon, Martine, Déglon, Nicole, Freche, Dominik, Glenn Dallérac, Lübke, Joachim H. R., Luebke, Joachim H. R., Cohen-Salmon, M.   +46 more
core   +1 more source

Connexin-43-dependent ATP release mediates macrophage activation during sepsis. [PDF]

, 2019
Bacterial spillage into a sterile environment following intestinal hollow-organ perforation leads to peritonitis and fulminant sepsis. Outcome of sepsis critically depends on macrophage activation by extracellular ATP-release and associated autocrine ...
Candinas, Daniel, Dosch, Michel, Beldi, Guido, Stroka, Deborah, Zindel, Joël, Jebbawi, Fadi, Melin, Nicolas, Sanchez-Taltavull, Daniel   +7 more
core   +2 more sources

Connexin-43 hemichannel mediated ATP release stimulates fibroblast activation in an in vitro model of diabetic kidney disease

, 2022
Aims: Tubulointerstitial fibrosis is the underlying pathology of diabetic nephropathy and develops in response to aberrant activation of multiple cell types within and around the proximal tubule of the kidney, including extracellular matrix (ECM ...
Claire Hills (17159905), Chelsy L. Cliff (17063201), Bethany Williams (17170132), Paul Squires (17167891), I. Demirel (17925383)   +4 more
core   +5 more sources

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

Studies of intercellular Ca2+ signaling and gap-junction coupling in the developing cochlea of mouse models affected by congenital hearing loss [PDF]

, 2013
Connexin 26 (Cx26) and connexin 30 (Cx30) form gap junction channels that allow the intercellular diffusion of the Ca2+ mobilizing second messenger IP3.
Rodriguez Hernandez, Laura
core  

Gap junctions modulate interkinetic nuclear movement in retinal progenitor cells [PDF]

, 2005
During early retinal development, progenitor cells must divide repeatedly to expand the progenitor pool. During G1 and G2 of the cell cycle, progenitor cell nuclei migrate back-and-forth across the proliferative zone in a process termed interkinetic ...
Lüneborg, N.L., Mobbs, Peter, Becker, D.L., Becker, David L., Pearson, R.A., Mobbs, P., Pearson, Rachael A.; id_orcid, Lüneborg, Nanna L.   +7 more
core   +1 more source