Results 51 to 60 of about 5,562,313 (185)
Advanced Science, EarlyView.A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao +9 more
wiley +1 more source
Uncoupling of the Astrocyte Syncytium Differentially Affects AQP4 Isoforms
Cells, 2020 The water channel protein aquaporin-4 (AQP4) and the gap junction forming proteins connexin-43 (Cx43) and connexin-30 (Cx30) are astrocytic proteins critically involved in brain water and ion homeostasis.
Shirin Katoozi +10 more
doaj +1 more source
Advanced Science, EarlyView.This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su +9 more
wiley +1 more source
Advanced Science, EarlyView.Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami +7 more
wiley +1 more source
Structural and functional diversity of connexin genes in the mouse and human genome [PDF]
, 2002 Gap junctions are clustered channels between contacting cells through which direct intercellular communication via diffusion of ions and metabolites can occur.
Willecke, K +7 more
core +2 more sources
Advanced Science, EarlyView.Mitochondrial localization of Cx26 emerges as a double‐edged sword in colorectal cancer. PIMT‐mediated methylation of Cx26 promotes its mitochondrial localization and stability. Mitochondrial Cx26 then facilitates ER‐mitochondria communication and Ca2+ signaling, thereby promoting metastatic progression. Bortezomib exploits this malignant adaptation by
Jie Wang +9 more
wiley +1 more source
Allele-specific impairment of GJB2 expression by GJB6 deletion del(GJB6-D13S1854). [PDF]
PLoS ONE, 2011 Mutations in the GJB2 gene, which encodes connexin 26, are a frequent cause of congenital non-syndromic sensorineural hearing loss. Two large deletions, del(GJB6-D13S1830) and del(GJB6-D13S1854), which truncate GJB6 (connexin 30), cause hearing loss in ...
Juan Rodriguez-Paris +3 more
doaj +1 more source
Advanced NanoBiomed Research, EarlyView.Schematic representation of acellular matrix generation from human uterine fibroblast cells, coating on polycaprolactone electrospun nanofibers, and subsequent in vitro and in vivo characterization. A tissue‐engineered scaffold tailored for uterine myometrium‐specific regeneration is designed. The electrospinning technique was used to fabricate aligned
Srividya Hanuman +3 more
wiley +1 more source
Connexin 36 as a Regulator of Consummatory Behaviour [PDF]
, 2014 Gap junctions enable metabolic and electrical coupling of adjacent cells. Connexin 36 (Cx36) is a gap junction protein found predominantly in mammalian neurons.
Christian, David
core
Connexin-43 (Cx43) channels do not mediate the mean event probability.
, 2019 (A) Localization of Cx43 (white in the Cx43 only image, yellow in the composite image). Cells were counter-stained with rhodamine phalloidin (red) and DAPI (blue).
Sung Jun Son (6631073) +8 more
core +1 more source