Results 61 to 70 of about 5,562,313 (185)
Connexin mRNA distribution in adult mouse kidneys [PDF]
, 2021 Kidneys are thought to express eight different connexin isoforms (i.e., Cx 26, 30, 32, 37, 40, 43, 45, and 46), which form either hemichannels or gap junctions serving to intercellular communication and functional synchronization.
Boudriot, Franz-Fabian +2 more
core +1 more source
Nature Communications, 2017 A point mutation in the gap-junction protein connexin 30 stops early onset age-related hearing loss. Here, the authors show that gap junctions contribute to cochlear micromechanics and that cochlear amplification is likely controlled by extracellular ...
Victoria A. Lukashkina +4 more
doaj +1 more source
GJB2 and GJB6 Mutations in Non-Syndromic Childhood Hearing Impairment in Ghana
Frontiers in Genetics, 2019 Our study aimed to investigate GJB2 (connexin 26) and GJB6 (connexin 30) mutations associated with non-syndromic childhood hearing impairment (HI) as well as the environmental causes of HI in Ghana. Medical reports of 1,104 students attending schools for
Samuel M. Adadey +8 more
doaj +1 more source
The Anatomical Record, EarlyView.Abstract The vertebrate skull is composed of bones derived from neural crest cells and mesoderm. The evolutionary capacity of the skull has been linked, in part, to the emergence of neural crest cells; however, this increased capacity for evolutionary change requires that variation within neural crest‐ and mesoderm‐derived bones remains partly ...
Alyssa C. Moore +5 more
wiley +1 more source
GJB2 and GJB6 genes mutations in children with non-syndromic hearing loss
Romanian Journal of Laboratory Medicine, 2017 Introduction. At the moment there is not enough data in Romania about the incidence of the main genetic mutations which can cause hearing loss.
Lazăr Călin +4 more
doaj +1 more source
Clinical Anatomy, EarlyView.ABSTRACT Human atrial chambers derive from distinct embryonic anlagens, the original embryonic atria gradually transforming into the so‐called auricles, or atrial appendages. This study quantifies macroscopic variations in pectinate muscle architecture in human atrial appendages and evaluates their visualization using clinical imaging modalities.
Markéta Lexová +11 more
wiley +1 more source
Developmental Dynamics, EarlyView.Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley +1 more source
Rat Gap Junction Connexin-30 Inhibits Proliferation of Glioma Cell Lines
, 2001 peer reviewedConnexins, the structural components of gap junctions, control cell growth and differentiation and are believed to belong to a family of tumour suppressor genes. Studies on connexin localization in brain showed that several of these proteins
Gros, D. +6 more
core +1 more source
Hearing impairment in Dutch patients with connexin 26 (GJB2) and connexin 30 (GJB6) mutations. [PDF]
, 2005 Contains fulltext : 47759.pdf (Publisher’s version ) (Closed access)OBJECTIVE: Despite the identification of mutations in the connexin 26 (GJB2) gene as the most common cause of recessive nonsyndromic hearing loss, the pattern of ...
Huygen, P.L.M. +9 more
core +1 more source
Triggered Calcium Lightning Programs Cochlear Development
Exploration, EarlyView.Summary: Before the onset of hearing, the developing inner ear generates spontaneous calcium signals that are thought to guide maturation. In this study, we discovered a rapid and widespread calcium flash—dubbed “Ca2+ lightning”—originating from supporting cells beneath the sensory hair cells, which triggers coordinated calcium waves across the entire ...
Qiang Ma +13 more
wiley +1 more source