Results 21 to 30 of about 5,562,313 (185)

Connexin-43 hemichannels orchestrate NOD-like receptor protein-3 (NLRP3) inflammasome activation and sterile inflammation in tubular injury.

, 2023
Background: Without aviable cure, chronic kidney disease is a global health concern. Inflammatory damagein and around the renal tubules dictates disease severity and is contributed to by multiple cell types.
Christos Chadjichristos (17752530), Jessy Renciot (17752536), Claire Hills (17159905), Elena Roger (17752533), Chelsy Cliff (17171551), Gareth Price (17165578), Panagiotis Kavvadas (17752539), Paul Squires (17167891), Safia Hadjadj (17752542)   +8 more
core   +5 more sources

SUPPLEMENTARY MATERIALS: A microtubule-Connexin-43 regulatory link suppresses arrhythmias and cardiac fibrosis in Duchenne muscular dystrophy mice.

, 2022
This is supplementary material of the manuscript entitled: Microtubule-Connexin-43 regulation suppresses arrhythmias and fibrosis in Duchenne muscular dystrophy mice.
Lai-hua Xie (12361865), Natalia Shirokova (12361869), Eric Himelman (12361851), Mauricio Lillo (12361858), Diego Fraidenraich (12360910), George Rodney (12361862), Julie Nouet (12361857), Alexander chong (12361859), Xander Wehrens (12361860), Jorge Contreras (12361870), Delong Zhou (13149067)   +10 more
core   +1 more source

Visfatin reduces gap junction mediated cell-to-cell communication in proximal tubule-derived epithelial cells [PDF]

, 2013
Background/Aims: In the current study we examined if the adipocytokine, visfatin, alters connexinmediated intercellular communication in proximal tubule-derived epithelial cells.
Mark J. Wall, Hills, Claire E., Michael I. Kerr, Paul E. Squires, Claire E. Hills, Kerr, Michael I., Squires, Paul E., Wall, Mark J.   +7 more
core   +1 more source

Mechanistic effect of the human GJB6 gene and its mutations in HaCaT cell proliferation and apoptosis

Brazilian Journal of Medical and Biological Research, 2018
We constructed lentiviral vectors containing the human wild-type GJB6 gene and the mutant variants A88V and G11R. The three proteins were stably expressed by the Tet-on system in the HaCaT cell line and used to study the functional effect of the variants.
Yuting Lu, Ruili Zhang, Zhenying Wang, Shuhua Zhou, Yali Song, Lamei Chen, Nan Chen, Wenmin Liu, Canan Ji, Wangli Wu, Li Zhang   +10 more
doaj   +1 more source

Frequency of GJB2 mutations, GJB6‐D13S1830 and GJB6‐D13S1854 deletions among patients with non‐syndromic hearing loss from the central region of Iran

Molecular Genetics & Genomic Medicine, 2019
Background In the present study, we investigate the prevalence of the GJB2 gene mutations, and deletions in the GJB6 gene, namely del (GJB6‐D13S1830) and del (GJB6‐D13S1854), in patients with autosomal recessive non‐syndromic hearing loss (ARNSHL) from ...
Hossein Naddafnia, Zahra Noormohammadi, Shiva Irani, Iman Salahshoorifar   +3 more
doaj   +1 more source

Connexin30-Deficiency Causes Mild Hearing Loss With the Reduction of Endocochlear Potential and ATP Release

Frontiers in Cellular Neuroscience, 2022
GJB2 and GJB6 are adjacent genes encoding connexin 26 (Cx26) and connexin 30 (Cx30), respectively, with overlapping expressions in the inner ear. Both genes are associated with the commonest monogenic hearing disorder, recessive isolated deafness DFNB1 ...
Junmin Chen, Junmin Chen, Junmin Chen, Penghui Chen, Penghui Chen, Penghui Chen, Baihui He, Baihui He, Baihui He, Tianyu Gong, Tianyu Gong, Tianyu Gong, Yue Li, Yue Li, Yue Li, Jifang Zhang, Jifang Zhang, Jifang Zhang, Jingrong Lv, Jingrong Lv, Jingrong Lv, Fabio Mammano, Fabio Mammano, Shule Hou, Shule Hou, Shule Hou, Jun Yang, Jun Yang, Jun Yang   +28 more
doaj   +1 more source

Upregulation of Connexin 30 in Intestinal Phenotype Gastric Cancer and Its Reduction during Tumor Progression [PDF]

, 2010
Aims: The mucin phenotype is associated with clinicopathological findings and tumorigenesis in gastric cancer (GC). The aim was to search for a novel marker regulating the intestinal phenotype of GC. Methods and Results: We performed microarray analyses,
Naoya Sakamoto, Sentani, Kazuhiro, Kazuhiro Sentani, Naohide Oue, Katsuhiro Anami, Sakamoto, Naoya, Hiroki Sasaki, Sasaki, Hiroki, Wataru Yasui, Anami, Katsuhiro, Yasui, Wataru, Oue, Naohide, Naito, Yutaka, Yutaka Naito, Aoyagi, Kazuhiko, Kazuhiko Aoyagi   +15 more
core   +1 more source

A Human-Derived Monoclonal Antibody Targeting Extracellular Connexin Domain Selectively Modulates Hemichannel Function

Frontiers in Physiology, 2019
Connexin hemichannels, which are plasma membrane hexameric channels (connexons) composed of connexin protein protomers, have been implicated in a host of physiological processes and pathological conditions. A number of single point pathological mutations
Gaia Ziraldo, Gaia Ziraldo, Damiano Buratto, Yuanyuan Kuang, Liang Xu, Andrea Carrer, Andrea Carrer, Chiara Nardin, Chiara Nardin, Francesco Chiani, Anna Maria Salvatore, Gaetano Paludetti, Gaetano Paludetti, Richard A. Lerner, Guang Yang, Francesco Zonta, Fabio Mammano, Fabio Mammano, Fabio Mammano   +18 more
doaj   +1 more source

In vivo genetic manipulation of inner ear connexin expression by bovine adeno-associated viral vectors

Scientific Reports, 2017
We have previously shown that in vitro transduction with bovine adeno–associated viral (BAAV) vectors restores connexin expression and rescues gap junction coupling in cochlear organotypic cultures from connexin–deficient mice that are models DFNB1 ...
Giulia Crispino, Fabian Galindo Ramirez, Matteo Campioni, Veronica Zorzi, Mark Praetorius, Giovanni Di Pasquale, John A. Chiorini, Fabio Mammano   +7 more
doaj   +1 more source

Molecular composition and distribution of gap junctions in the sensory epithelium of the human cochlea—a super-resolution structured illumination microscopy (SR-SIM) study

Upsala Journal of Medical Sciences, 2017
Background: Mutations in the GJB2 gene, which encodes the Connexin26 (Cx26) protein, are the most common cause of childhood hearing loss in American and European populations.
Wei Liu, Hao Li, Fredrik Edin, Johan Brännström, Rudolf Glueckert, Annelies Schrott-Fischer, Matyas Molnar, Dirk Pacholsky, Kristian Pfaller, Helge Rask-Andersen   +9 more
doaj   +1 more source