Results 11 to 20 of about 36,882 (280)

Nucleoside-Modified mRNA Encoding Alpha-Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC-Derived Cardiomyocytes. [PDF]

Adv Sci (Weinh)
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Juchem M, Oehlsen L, Ersoy S, Ye JL, Weber N, Mohr E, Agyapong W, Liu J, Fuchs M, Xiao K, Jahn C, Eggenschwiler R, Cantz T, Beimdiek J, Buettner FFR, Kraft T, Hegermann J, Knorr IJ, Ernst L, Feldbrügge L, Puffert R, Schmidt K, Bär C, Hoepfner J, Thum T.   +24 more
europepmc   +2 more sources

Platycodon grandiflorus-Derived Nanovesicles Sensitize Gastric Cancer to T Cell Killing via Ferroptosis-Driven Membrane Mechanical Remodeling. [PDF]

Adv Sci (Weinh)
Plant‐derived nanovesicles from Platycodon grandiflorus act as bioactive lipid delivery platforms that transport γ‐linolenic acid into gastric cancer cells. This lipid cargo promotes ferroptotic lipid peroxidation, remodels membrane mechanics, and increases tumor‐cell susceptibility to cytotoxic T‐cell attack.
Wu J, Zhang R, Duan Y, Huo S, Zhang X, Xing Y, Ma L, Jiang T, Chen X, Sun Q.   +9 more
europepmc   +2 more sources

GLA-SE drives inflammasome activation.

, 2021
(A, B) Mice were inoculated with B16 melanoma tumors then treated with ILV/mIL12, srRNA/mIL12, GLA-SE or a combination of IL12 therapy with GLA-SE. To avoid inactivation of ILVs with SE adjuvant, injections were staggered such that there was a 24 hour ...
Tina C. Albershardt (11785208), Rebecca Reeves (11785211), Peter Berglund (1918321), Reice James (11785214), Jordan Krull (11785217), Andrea J. Parsons (11785220), Jardin A. Leleux (11785205), Jan ter Meulen (11785223)   +7 more
core   +1 more source

GLA-SE improves IL12 induced tumor control, antigen-specific T cell expansion and myeloid cell activation.

, 2021
(A, B) Mice bearing subcutaneous B16 melanoma tumors in their right flanks were treated initially with srRNA/mIL12 with or without the combination of the TLR4 agonist GLA-SE (n = 9–10).
Tina C. Albershardt (11785208), Rebecca Reeves (11785211), Peter Berglund (1918321), Reice James (11785214), Jordan Krull (11785217), Andrea J. Parsons (11785220), Jardin A. Leleux (11785205), Jan ter Meulen (11785223)   +7 more
core   +1 more source

Cascading effects of glacier retreat: Hydro-chemical shifts and macroinvertebrate responses in Andean glacier-fed streams [PDF]

Journal of the Bulgarian Geographical Society
The retreat of tropical glaciers in the Peruvian Andes, particularly in the Cordillera Blanca, has significantly altered hydrogeological and geochemical processes in mountain water-sheds.
Fiorella La Matta Romero, Vanessa Arevalo-Seijas, David Valqui-Peña, Moya MacDonald, Jemma Wadham, Raul Loayza-Muro   +5 more
doaj   +3 more sources

Generation of a GLA knock-out human-induced pluripotent stem cell line, KSBCi002-A-1, using CRISPR/Cas9

Stem Cell Research, 2020
Fabry disease is an X-linked inherited disease caused by a mutation in the galactosidase alpha (GLA) gene. Here, we generated a GLA knock-out cell line (GLA-KO hiPSCs) from normal human-induced pluripotent stem cells (hFSiPS1) using the CRISPR-Cas9 ...
Young-Kyu Kim, Ji Hoon Yu, Sang-Hyun Min, Sang-Wook Park   +3 more
doaj   +1 more source

Prolonged cognitive dysfunction in patient with splenial lesion of the corpus callosum caused by glufosinate ammonium poisoning

Turkish Journal of Emergency Medicine, 2021
Glufosinate ammonium (GLA) is widely used as a commercial herbicide in many countries. Neurotoxicity of GLA has been associated with serious neurological complications such as loss of consciousness, convulsions, and memory impairment.
Hyun Jung Lee, Jeong Ho Kang
doaj   +1 more source

Enzymatic properties and clinical associations of serum alpha‐galactosidase A in Parkinson's disease

Annals of Clinical and Translational Neurology, 2023
Objective Recent studies have revealed an association between Parkinson's disease (PD) and Fabry disease, a lysosomal storage disorder; however, the underlying mechanisms remain to be elucidated.
Yasuaki Mizutani, Kazuki Nawashiro, Reiko Ohdake, Harutsugu Tatebe, Sayuri Shima, Akihiro Ueda, Junichiro Yoshimoto, Mizuki Ito, Takahiko Tokuda, Tatsuro Mutoh, Hirohisa Watanabe   +10 more
doaj   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Pharmacoeconomic comparison of insulin glargine and insulin detemir in diabetes mellitus type 2

Качественная клиническая практика, 2020
Second generation insulin analogue — insulin glargine 300 UI/ml (GLA-300) — can provide an effective control of Diabetes Mellitus (DM) with minimal risk of hypoglycemic events and prevent of cardiovascular complications or events (CVS).
I. N. Dyakov, S. K. Zyryanov
doaj   +1 more source