Review on the Diverse Biological Effects of Glabridin
Drug Design, Development and Therapy, 2023 Jianhong Zhang,1,2,* Xinhui Wu,3,* Baiyin Zhong,1,* Qicheng Liao,1 Xin Wang,1 Yuankang Xie,1 Xiao He1 1Department of Hepatobiliary Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, People’s Republic of China ...
Xie Yuankang, Qicheng Liao
exaly +4 more sources
The antitumor mechanisms of glabridin and drug delivery strategies for enhancing its bioavailability [PDF]
Frontiers in OncologyGlabridin, a flavonoid derived from the plant Glycyrrhiza glabra, has garnered significant attention due to its diverse pharmacological effects, including antioxidant, antibacterial, anti-inflammatory, hypolipidemic, and hypoglycemic activities.
Chong Li +9 more
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Mechanistic Insights into the Membrane Permeabilization Activity of Antimicrobial Prenylated Isoflavonoids: A Comparative Study of Glabridin, Wighteone, and Lupiwighteone. [PDF]
J Agric Food ChemPrenylated isoflavonoids have shown remarkable antimicrobial activity. Previous studies showed that the antimicrobial compounds glabridin and wighteone induced membrane permeabilization in microbial cells.
Bombelli A +7 more
europepmc +2 more sources
Glabridin improves cardiac remodeling after myocardial infarction by activating PPARγ to regulate the ubiquitination and degradation of EGFR [PDF]
Biology DirectBackground Acute myocardial infarction leads to myocardial inflammation and necroptosis, and is a major cause of heart failure, cardiovascular dysfunction, and mortality.
Zixuan Li +9 more
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Glabridin Inhibits Melanogenesis and Melanin Transfer via Wnt/β-Catenin Pathway and Rho Family GTPase-Mediated Dendritic Formation Suppression [PDF]
PharmaceuticalsBackground: Glabridin, a natural compound derived from Glycyrrhiza glabra L., possesses skin-lightening effects. This study aims to further elucidate the depigmentation mechanism of glabridin by investigating its effects on melanogenesis and melanin ...
Lili Li +4 more
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Glabridin Alleviates Oxidative Stress-Induced Osteoporosis by Targeting the Akt/NF-ĸB and Akt/GSK-3β Pathways. [PDF]
Int J Mol SciDiabetes-related osteoporosis has been known to be a consequence of oxidative stress caused by excessive reactive oxygen species (ROS) production in the tissues. Despite the increase in the number of individuals with diabetes-related osteoporosis year on
Tipbunjong C +5 more
europepmc +2 more sources
A Narrative Review of the Multi-Target Mechanisms of Glabridin in Skin Lightening [PDF]
Clinical, Cosmetic and Investigational DermatologyXin Nie, Ziyuan Ma, Anning Wang, Xin Zhang, Anzhang LiGuyu Qingnang Institute of Biotechnology, Guangzhou Qingnang Biotechnology Co., Ltd., Guangzhou, Guangdong, People’s Republic of ChinaCorrespondence: Xin Nie; Anzhang Li, Email niexin@guyu.com.cn ...
Nie X, Ma Z, Wang A, Zhang X, Li A
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Overestimated cytotoxicity and underestimated whitening efficacy of glabridin: A result of its poor solubility in DMSO. [PDF]
PLoS OneGlabridin is widely used as a whitening agent in cosmetics, but its cytotoxicity remains a key concern in safety evaluations. In typical cytotoxicity assays, glabridin is dissolved in dimethyl sulfoxide (DMSO) before being added to the cell culture ...
Liu H, Wang A, Chen X, Hou S, Li A.
europepmc +2 more sources
Seizing the key nodes in glabridin biosynthesis network: identification of enzymes for producing licorice hairy roots with high levels of glabridin [PDF]
Molecular HorticultureGlabridin holds significant value in the pharmaceutical and cosmetics industry. Due to the challenges associated with chemical synthesis, Glycyrrhiza glabra (licorice) remains the only source of glabridin.
Ningxin Jiang +10 more
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Glabridin content and metabolic effects of liquorice confectionaries: A secondary analysis of a randomized crossover trial in young adults. [PDF]
PLoS ONEBackgroundLiquorice, a popular confectionary product, contains several bioactive compounds. Amongst them, glycyrrhizic acid is associated with increased blood pressure, and glabridin is associated with anti-inflammatory and glucose-lowering effects.
Anna Åstrand +4 more
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