Results 21 to 30 of about 2,770 (195)

Block-building with yeast to elucidate an artificial pathway for de novo biosynthesis of glabridin [PDF]

Nature Communications
Prenylated phytochemicals like glabridin are valuable therapeutics and cosmetics, yet their plant scarcity and arduous synthesis hinder industrial supply. Rebuilding pathways in microbes is hampered by complex topology and carbon-cofactor competition. In
Hanning Deng, Lu Cao, Shan Li, Changtai Zhang, Weizhu Zeng, Xinrui Zhao, Jingwen Zhou   +6 more
doaj   +2 more sources

Glabridin Suppresses Macrophage Activation by Lipoteichoic Acid In Vitro: The Crucial Role of MAPKs-IL-1β-iNOS Axis Signals in Peritoneal and Alveolar Macrophages

Biomolecules
Inflammation, a fundamental response to infection and injury, involves interactions among immune cells and signaling molecules. Dysregulated inflammation contributes to diseases such as autoimmune disorders and cancer.
Shaw-Min Hou, Chun-Ming Yang, Wei-Chieh Huang, Ssu-Wei Cheng, Ting-Lin Yen, Chih-Wei Hsia, Cheng-Ying Hsieh, Chih-Hsuan Hsia   +7 more
doaj   +2 more sources

Effect of the flavonoid compound glabridin on tachyzoites and bradyzoites of Toxoplasma gondii. [PDF]

Parasit Vectors
Toxoplasma gondii (T. gondii) is one of the most prevalent parasites worldwide. At present, the majority of drugs used for the treatment of toxoplasmosis target the tachyzoite stage of T.
Qiu Y, Wang W, Wang Q, Lin H, Bai Y, Zhang J.   +5 more
europepmc   +2 more sources

Absolute configuration of naturally occurring glabridin [PDF]

, 2013
The title compound {systematic name: 4-[(3R)-8,8-dimethyl-3,4-di­hydro-2H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol, commonly named glabridin}, C20H20O4, is a species-specific biomarker from the roots Glycyrrhiza glabra L. (European licorice, Fabaceae).
Bernard D Santarsiero (7942562), Guido F Pauli (7942559), Charlotte Simmler (238586), Frank R Fronczek (1343286)   +3 more
core   +7 more sources

Glabridin alleviates ischemic stroke-induced neurodamage via the PI3K/Akt pathway. [PDF]

Cytotechnology
Wang J, Wang X, Li T.
europepmc   +2 more sources

Enhanced Whitening Effect of the Formulations via Inhibition of Tyrosinase Activity by Combination of 4-n-Butylresorcinol, Licochalcone A and Glabridin at an Optimal Ratio. [PDF]

Skin Res Technol
ABSTRACT Background Companies launch tons of skin‐whitening products to cater to the consumer market. Though skin‐whitening cosmeceuticals are continuously developing, most cosmeceuticals are used alone, there is very little academic research conducting investigations into the effect of skin‐whitening cosmeceutical combinations. Objective In this study,
Zhang T, Wang Y, Xu Y, Liu Y, Zhuang B, Zhang X, Liao C, Liu W, Ma Y.   +8 more
europepmc   +2 more sources

Glabridin mediate caspases activation and induces apoptosis through JNK1/2 and p38 MAPK pathway in human promyelocytic leukemia cells. [PDF]

PLoS ONE, 2014
BACKGROUND: Glabridin, a prenylated isoflavonoid of G. glabra L. roots, has been associated with a wide range of biological properties such as regulation of energy metabolism, estrogenic, neuroprotective, anti-osteoporotic, and skin-whitening in previous
Hsin-Lien Huang, Ming-Ju Hsieh, Ming-Hsien Chien, Hui-Yu Chen, Shun-Fa Yang, Pei-Ching Hsiao   +5 more
doaj   +1 more source

Glabridin Therapy Reduces Chronic Allodynia, Spinal Microgliosis, and Dendritic Spine Generation by Inhibiting Fractalkine-CX3CR1 Signaling in a Mouse Model of Tibial Fractures

Brain Sciences, 2023
Patients undergoing bone fractures frequently suffer from irritating chronic pain after orthopedic repairs. Chemokine-mediated interactions between neurons and microglia are important steps for neuroinflammation and excitatory synaptic plasticity during ...
Juan Long, Hongbing Liu, Zhimin Qiu, Zhong Xiao, Zhongqiu Lu   +4 more
doaj   +1 more source

The mechanisms of melanogenesis inhibition by glabridin: molecular docking, PKA/MITF and MAPK/MITF pathways

Food Science and Human Wellness, 2023
Glabridin is the main ingredient of hydrophobic fraction in licorice extract and has been shown to have anti-melanogenesis activity in skins. However, the underlying mechanism(s) remain not completely understood.
Chunxing Pan, Xiaoying Liu, Yating Zheng, Zejun Zhang, Yongliang Li, Biao Che, Guangrong Liu, Lanyue Zhang, Changzhi Dong, Haji Akber Aisa, Zhiyun Du, Zhengqiang Yuan   +11 more
doaj   +1 more source

Herbal Extracts and Plant-Derived Bioactives in Atopic Dermatitis: Evidence, Mechanisms, Pediatric Safety, and Translational Priorities. [PDF]

Food Sci Nutr
Food‐derived bioactives, herbal extracts, and standardized botanical products are being investigated as adjunctive strategies for atopic dermatitis. Their biological activity is shaped not only by plant source and nominal dose, but also by fermentation, drying, heating, extraction, food‐matrix binding, gastrointestinal transformation, and formulation ...
Zeng M, Yuan Q, Huang S, Lu X.
europepmc   +2 more sources