Results 21 to 30 of about 36,882 (280)

Glaucocalyxin A Inhibits the Malignancies of Gastric Cancer Cells by Downregulating MDM2 and RNF6 via MiR-3658 and the SMG1-UPF mRNA Decay Pathway

open access: yesFrontiers in Oncology, 2022
Gastric cancer (GC) ranks as the most common gastrointestinal cancer and is among the leading causes of cancer death worldwide. Glaucocalyxin A (GLA), an entkauranoid diterpene isolated from Rab-dosia japonica var., possesses various bioactivities.
Yanqi Liu   +3 more
doaj   +1 more source

Insulin Toujeo® — a Novel Basal Long-Acting Insulin Formulation. Part 2. Clinical Efficacy and Safety

open access: yesMìžnarodnij Endokrinologìčnij Žurnal, 2015
This review, consisting of two parts, considers a new formulation of insulin glargine (rDNA origin) in the form of injections 300 U/ml (Gla-300, Toujeo®).
V.V. Poltorak   +2 more
doaj   +1 more source

Preparation, optimization of the inclusion complex of glaucocalyxin A with sulfobutylether-β-cyclodextrin and antitumor study

open access: yesDrug Delivery, 2019
Glaucocalyxin A (GLA), is a diterpenoid extracted from Hara and has been studied for decades for its diverse bioactivities. However, GLA presents poor solubility in water and low bioavailability through oral administration which has hindered its ...
Lili Ren, Jingjing Wang, Guoguang Chen
doaj   +1 more source

Insulin Toujeo® — a Novel Basal Long-Acting Insulin Formulation. Part 1. Pharmacokinetic and Pharmacodynamic Aspects

open access: yesMìžnarodnij Endokrinologìčnij Žurnal, 2015
This review, consisting of two parts, considers a new formulation of insulin glargine (rDNA origin) in the form of injections 300 U/ml (Gla-300, Toujeo®).
V.V. Poltorak   +2 more
doaj   +1 more source

Simultaneous overexpression of ∆6-, ∆12- and ∆9-desaturases enhanced the production of γ-linolenic acid in Mucor circinelloides WJ11

open access: yesFrontiers in Microbiology, 2022
Mucor circinelloides WJ11, an oleaginous filamentous fungus, produces 36% lipid of its cell dry weight when cultured in a high C/N ratio medium, however, the yield of γ-linolenic acid (GLA) is insufficient to make it competitive with other plant sources.
Xiuwen Wang   +11 more
doaj   +1 more source

Regeneration in Zebrafish (Danio rerio) fins: pattern of expression of mineralization–related Gla proteins [PDF]

open access: yes, 2006
Teleost fishes have the exceptional ability to largely regenerate severed appendages comprising several different tissues. Fin regeneration starts through the formation of heterogeneous mesenchyma-like cells, named blastema, and located between stump ...
Brito, A. B.   +2 more
core   +1 more source

GLA - GLUZ [PDF]

open access: yes
OnLine Card Catalogue drawer 0148 (GLA - GLUZ).
Craft, Edward
core   +5 more sources

New Basal Insulin Toujeo Solostar: Increased Therapeutic Potential for the Control of Dysglycaemia in Diabetes Mellitus

open access: yesMìžnarodnij Endokrinologìčnij Žurnal, 2016
This review examines the new formulation of insulin glargine (recombinant) in the form of injections 300 U/ml (Gla‑300, Toujeo®). Gla‑300 is a next generation basal insulin with a novel formulation of insulin glargin delivering the same amount of insulin,
V.V. Poltorak
doaj   +1 more source

Development and optimization of the Glabridin-loaded dissolving microneedle for enhanced treatment of keloid

open access: yesInternational Journal of Pharmaceutics: X
Glabridin (Gla) has been reported to have significant effects in scar treatment, and however, the water insolubility of Gla leads to its poor transdermal absorption ability, which affects its bioactivities.
Juan Guo   +10 more
doaj   +1 more source

Identification and functional characterization of the first deep intronic GLA mutation (IVS4+1326C>T) causing renal variant of Fabry disease

open access: yesOrphanet Journal of Rare Diseases, 2022
Background Fabry disease (FD, OMIM #301500) is an X-linked lysosomal disorder caused by the deficiency of α-galactosidase A (α-GalA), encoded by the GLA gene.
Xuantong Dai   +5 more
doaj   +1 more source

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