Results 181 to 190 of about 2,632 (194)

Enhanced skin permeation of glabridin using eutectic mixture-based nanoemulsion

Drug Delivery and Translational Research, 2017
This study aimed to investigate the performance of the eutectic mixture of menthol and camphor (1:1, w/w) in nanoemulsion formulation for enhanced transdermal penetration of water-insoluble glabridin. Glabridin solubility in different media was determined by a shaking bottle method.
Chen, Liu, Jin, Hu, Hong, Sui, Qipeng, Zhao, Xia, Zhang, Wenping, Wang   +5 more
openaire   +2 more sources

Extraction of glabridin using imidazolium-based ionic liquids

Separation and Purification Technology, 2012
Abstract The present study aims to extract bioactive glabridin from licorice extract using imidazolium-based ionic liquids (ILs). A series of 1-alkyl-3-methylimidazolium ionic liquids with different anions and alkyl chain lengths of cations were selected to extract glabridin.
Xueqin Li, Ruili Guo, Xiaopeng Zhang, Xiaoyue Li   +3 more
openaire   +1 more source

Structural Aspects of The Inhibitory Effect of Glabridin on LDL Oxidation

Free Radical Biology and Medicine, 1998
The inhibitory effects of glabridin, an isoflavan isolated from licorice (Glycyrrhiza glabra) root, and its derivatives on the oxidation of LDL induced by copper ions or mediated by macrophages were studied, in order to evaluate the contribution of the different parts of the isoflavan molecule to its antioxidant activity.
P A, Belinky, M, Aviram, S, Mahmood, J, Vaya   +3 more
openaire   +2 more sources

Glabridin Alleviates Metabolic Disorders in Diet‐Induced Diabetic Mice

Phytotherapy Research
ABSTRACTGlabridin (GLD) is a flavonoid derived from licorice. This study aims to evaluate GLD's therapeutic potential in ameliorating type 2 diabetes mellitus (T2DM) and elucidate its underlying mechanisms of action. A T2DM model was established using male C57BL/6J mice fed a high‐fat, high‐glucose diet.
Xiaoxue Yang, Kaiyi Lai, Jiayu Zhang, Ziyi Chen, Wenwen Ding, Yu Jiang, Ying Liu   +6 more
openaire   +2 more sources

Fabrication of sulfobutylether‐β‐cyclodextrin/glabridin inclusion complex for promoting bioactivities

Archiv der Pharmazie
AbstractAs the main active compound of Glycyrrhiza glabra L., glabridin (GLD) has been shown to have multiple bioactivities, whereas the clinical application of GLD is restricted by its low water solubility. In this study, GLD was encapsulated into a sulfobutylether‐β‐cyclodextrin (SBE‐β‐CD)‐based inclusion complex (SBE‐β‐CD/GLD) by the freeze‐drying ...
Wanru Wang, Kewen Tang, Chenggang Huang, An Liu   +3 more
openaire   +2 more sources

Discover the Maze-like Pathway for Glabridin Biosynthesis

AbstractTailoring enzymes diversify plant metabolite scaffolds through complex, context-dependent modifications, generating maze-like biosynthetic networks that complicate metabolic pathway reconstruction. Here, we systematically deconstructed and reconstructed the biosynthetic network of glabridin, a valuable skin-whitening isoflavone fromGlycyrrhiza.
Zhen Zhang, Wenqiang Li, Fanze Meng, Yanming Jin, Wentao Sun, Qina Kuang, Shichao Ren, Wei Liu, Liang Zhang, Lei Qin, Bo Lv, Haiyang Jia, Chun Li   +12 more
openaire   +1 more source

Glabridin protects osteoblastic MC3T3-E1 cells against antimycin A induced cytotoxicity

Chemico-Biological Interactions, 2011
Mitochondrial dysfunction, particularly respiratory chain disruption, is often responsible for aging-related bone diseases. In this study, the protective effects of glabridin, an isoflavan isolated from licorice root, against pharmacological inhibition of the respiratory chain were studied using osteoblastic MC3T3-E1 cells treated with antimycin A ...
openaire   +2 more sources

Glabridin inhibits proliferation and migration in hepatocellular carcinoma by regulating multi-targets

Journal of Ethnopharmacology
Glycyrrhiza uralensis Fisch. (GC) is widely utilized in traditional Chinese medicine (TCM) for its properties in Qi tonification, heat clearing, and detoxification. Within TCM theory, Qi is also implicated in tumor development. Numerous TCM formulas containing GC are used for their anti-tumor effects, and contemporary pharmacological research has ...
Fei, Wang, Chong, Yuan, Yi, Lu, Mojiao, Wu, Hezhen, Wu, Yifei, Liu, Yanfang, Yang   +6 more
openaire   +2 more sources

ChemInform Abstract: Total Synthesis of (.+‐.)‐Glabridin (I).

ChemInform, 2014
Wen‐Hua Ji, Qian‐Shan Gao, Yun‐Liang Lin, Hong‐Mei Gao, Xiao Wang, Yan‐Ling Geng   +5 more
openaire   +1 more source

SUPERCRITICAL FLUID EXTRACTION OF GLABRIDIN FROM GLYCYRRHIZA GLABRA

Frontiers on Separation Science and Technology, 2004
YUN-KYOUNG CHO, JONG-HOON RYU, GIO-BIN LIM, SANG-YUN LEE   +3 more
openaire   +1 more source