Results 161 to 170 of about 2,770 (195)

Glabridin mitigates osteoarthritis progression through modulation of the PI3K/AKT/FOXO3A autophagy axis.

Phytomedicine
BACKGROUND Osteoarthritis (OA) is a common degenerative joint disorder marked by the breakdown of cartilage and disrupted cellular balance. While Glabridin (Gla) has shown properties that are anti-inflammatory and antioxidant, the exact therapeutic ...
Linbing Lou, Zhu Zhu, Lei Xu, Zhi-Min Wu, Xiaofei Wang, Luqi Yuan, Haixiang Miao, Cunyi Xia, Jihang Dai   +8 more
semanticscholar   +1 more source

Glabridin from Glycyrrhiza glabra L. Exhibits Anti-Triple-Negative Breast Cancer Effects by Regulating Various Cell Cycle Genes.

Journal of Agricultural and Food Chemistry
Glabridin (GLA), a characteristic polyphenolic extracted from the renowned sweet plantGlycyrrhiza glabra L., demonstrates potent anticancer effects.
Chong Yuan, Zijie Lin, Ling-Li Zhang, Qi Tao, Hong-Mei Zheng, Yao-jun Feng, W. Zhong, Hong Cheng, Jun Shao, Man-Cheng Yu   +9 more
semanticscholar   +1 more source

Glabridin attenuates dibutyl phthalate-induced testicular toxicity via regulating oxidative stress, inflammation, apoptosis, and Wnt/β-catenin pathway.

Tissue & Cell
Dibutyl phthalate (DBP) is a member of phthalate esters which are considered as potent environmental toxicant owing to their damaging effects on different organs including testis.
Hesham M. Hassan, Hafsa Ashfaq, F. M. Alzahrani, K. Alzahrani, Abrar I. Aljohani   +4 more
semanticscholar   +1 more source

Nano-encapsulation of Glabridin using enzymatically hydrolyzed sodium caseinate for improved bioavailability and functional applications.

International Journal of Biological Macromolecules
Glabridin (Gla), a pyranoisoflavan, has diverse health benefits and significant applications in skincare due to its antioxidant, anti-inflammatory, anti-ageing, and UV-protective properties. This study aimed to enhance the entrapment efficiency of Gla by
Muhammad Tariq, Haole Qi, Zakirullah, Zakareya, Hao Liang   +4 more
semanticscholar   +1 more source

Glabridin ameliorates hemorrhagic shock induced acute kidney injury by activating Nrf2/HO-1 pathway.

Biochimica et Biophysica Acta - Molecular Basis of Disease
Glabridin, a bioactive compound extracted from licorice, exhibits anti-inflammatory and antioxidative stress effects. It has rarely been reported in hemorrhagic shock (HS)-induced acute kidney injury (AKI).
Liang-Hui Shu, Zhe Zhang, Nan Wang, Q. Yin, Yang Chao, Xin Ge   +5 more
semanticscholar   +1 more source

Thermosensitive, injectable, antibacterial glabridin liposome/chitosan dual network hydrogel for diabetic wound healing.

International Journal of Biological Macromolecules
Thermosensitive hydrogels show great potential in healing diabetic wounds, but they are still challenged by the long healing time, risk of infectivity, and accumulation of melanin.
Yu-Yang Cao, Duo-Ling Xu, Zhao Zu, Gen-Lu Xu, Yi-Xi Zeng, Jiyu Weng, Zhenhai Huang, Hong-Ping Xiang, Lan-Yue Zhang, Jinlong Ding, Hui Li   +10 more
semanticscholar   +1 more source

Epigallocatechin-3-Gallate and Glabridin Synergistically Inhibited Melanogenesis by Molecular Interaction and the MicroRNA–Microphthalmia-Related Transcription Factor Pathway

Journal of Medicinal Food
Epigallocatechin-3-gallate (EGCG) and glabridin (GLA) are two phytochemicals derived from homologous plants used for medicine and food that have demonstrated efficacy in inhibiting excessive production of melanin and promoting skin whitening properties ...
Jingwu Song, Zhaowen Chen, Tongtong Li, Wei-jia Xu, Guan Feng, Jian Ge   +5 more
semanticscholar   +1 more source

Structural and anti-ovarian cancer insights into the immunoglobulin G-glabridin nanocomplex.

International Journal of Biological Macromolecules
In this study, the formation of the immunoglobulin G-glabridin (IgG-GB) complex and nanocomplex was analyzed by assessing the structure, stability, solubility, and anticancer effects against the human epithelial ovarian cancer cell line SKOV3.
Zhi-Qiang Guo, Mengdie Tian, Min Zhou, Zhuo-Er Li, Meijun Li   +4 more
semanticscholar   +1 more source

In vitro and in vivo enhancement effect of glabridin on the antibacterial activity of colistin, against multidrug resistant Escherichia coli strains.

Phytomedicine
BACKGROUND The increase in antimicrobial resistance leads to complications in treatments, prolonged hospitalization, and increased mortality. Glabridin (GLA) is a hydroxyisoflavan from Glycyrrhiza glabra L.
Jiaxing Yang, Laiying Zhang, Xinlian He, Xupeng Gou, Z. Zong, Youfu Luo   +5 more
semanticscholar   +1 more source

Glabridin ameliorates oxidative stress and inflammation in a bovine intestinal cell line and a colitis mouse model

Iranian Journal of Veterinary Research
Background: Oxidative stress (OS) adversely affects the intestinal health and mucosal barrier function in dairy cows. Glabridin (Glab), a natural flavonoid derived from licorice, has been shown to mitigate stress-related damage due to its antioxidant ...
Y. An, J. Lu, X. Wang, C. Zhang, S.-H. Wang, Y. Ma, Y. Qiu, S.-H. Guo   +7 more
semanticscholar   +1 more source