Results 91 to 100 of about 5,635,835 (408)

Paleoglaciological reconstruction and geomorphological mapping of Dobrowolski Glacier, King George Island, Antarctica

Revista Brasileira de Geomorfologia, 2023
The paper aims to reconstruct the fluctuations of Dobrowolski Glacier, a tidewater glacier located in the inner position of the Admiralty Bay (King George Island, Antarctica), from the Little Ice Age (1400-1700) until the present.
Cleiva Perondi, Kátia Kellem da Rosa, Fabio José Guedes Magrani, Carina Petsch, Rosemary Vieira, Arthur Ayres Neto, Jefferson Cardia Simões   +6 more
doaj   +1 more source

Persistence of full glacial conditions in the central Pacific until 15,000 years ago [PDF]

, 2007
The magnitude of atmospheric cooling during the Last Glacial Maximum and the timing of the transition into the current interglacial period remain poorly constrained in tropical regions, partly because of a lack of suitable climate records.
Blard, P.-H., Bourlès, D., Lavé, J., Pik, R., Wagnon, P.   +4 more
core   +3 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Evolution of the Great Tehuelche Paleolake in the Torres del Paine National Park of Chilean Patagonia during the Last Glacial Maximum and Holocene [PDF]

, 2012
Indexación: Web of Science; ScieloRESUMEN. Una serie de morrenas glaciares se distribuyen desde el margen oriental de la cuenca de drenaje Torres del Paine a cerca del actual margen de los Campos de Hielo Patagónico, junto con una serie de terrazas ...
Airo, Alessandro, Calderón, Mauricio, Hervé, Francisco, Le Roux, Jacobus P., Solari, Marcelo A.   +4 more
core   +2 more sources

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Contribution à l'évaluation de la vitesse d'érosion des cirques glaciaires de quelques massifs anciens européens

Physio-Géo, 2011
Morphometric data from a sample of thirty glacial cirques located in European basement regions (Black Forest, South-West Ireland and Wales) assess the rate of glacial erosion.
Francis Huguet
doaj   +1 more source

Cause of the glacial period [PDF]

Journal of the Franklin Institute, 1899
n ...
openaire   +1 more source

Response of glacial-lake outburst floods to climate change in the Yarkant River basin on northern slope of Karakoram Mountains, China [PDF]

, 2010
Based on the glacial flood events and climate change in the Yarkant River basin during the past 50 years, the study investigated the long-term change of temperature and precipitation, the characteristics of glacial floods, the origin of sudden flood ...
Changchun, Chen, Chen, YN, Chinese Acad Sci, Xinjiang Inst Ecol & Geog, Key Lab Oasis Ecol & Desert Environm, Urumqi 830011, Peoples R China, Jingshi, Li, Liu, Weihong, Xu, Yaning, Yapeng   +9 more
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Consequences of glacial cycles for magmatism and carbon transport at mid-ocean ridges [PDF]

Earth Planet. Sci. Lett., 528, 115845 (2019), 2019
Magmatism and volcanism transfer carbon from the solid Earth into the climate system. This transfer may be modulated by the glacial/interglacial cycling of water between oceans and continental ice sheets, which alters the surface loading of the solid Earth.
arxiv   +1 more source