Antimicrobial Susceptibility of Glaesserella parasuis to Macrolides and Characterization of erm(T)-Carrying Mobile Elements on Chromosome [PDF]
AnimalsGlaesserella parasuis is the etiological agent of Glässer’s disease, which causes high morbidity and mortality in pigs worldwide. Macrolide resistance poses an urgent threat to their treatment, as macrolides are widely used for preventing and treating G.
Peng Zhang +8 more
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Baicalin Alleviates Piglet Immunosuppression Induced by Glaesserella parasuis via Promoting CD163/Tumor Necrosis Factor-like Weak Inducer of Apoptosis-Mediated Autophagy [PDF]
BiomoleculesGlaesserella parasuis (G. parasuis) causes vascular inflammation in piglets, resulting in vascular damage. However, the mechanism causing vascular inflammation remains unclear. Baicalin possesses an anti-inflammatory function.
Shulin Fu +9 more
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Comparison of the Glaesserella parasuis Virulence in Mice and Piglets [PDF]
Frontiers in Veterinary Science, 2021 In this study, we compared the virulence of the most common serovars of Glaesserella parasuis in China, serovars 4, 5, 12, and 13 (36 strains in total) in BALB/c mice and piglets. In mice, the median lethal doses (LD50s) of the four serovars were roughly 9.80 × 107–4.60 × 109 CFU, 2.10 × 108–8.85 × 109 CFU, 4.81 × 107–7.01 × 109 CFU, and 1.75 × 108–8 ...
Baichuan Qi +11 more
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Deletion of two-component system QseBC weakened virulence of Glaesserella parasuis in a murine acute infection model and adhesion to host cells [PDF]
PeerJ, 2022 The widespread two-component system (TCS), QseBC, involves vital virulence regulators in Enterobacteriaceae and Pasteurellaceae. Here we studied the function of QseBC in Glaesserella parasuis. A ΔqseBC mutant was constructed using a Glaesserella parasuis
Xuefeng Yan +7 more
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The Molecular Mechanism by Which miR-129a-3p Targets the TLR4/NF-κB Signaling Pathway to Regulate Inflammatory Damage in 3D4/21 Cells Infected with Glaesserella parasuis [PDF]
AnimalsGlaesserella parasuis (G. parasuis) is the primary pathogen responsible for Glässer’s disease and poses a significant threat to the global pig industry. MicroRNAs are a class of short, endogenous, single-stranded noncoding RNAs that play crucial roles in
Zhongbo Guo +8 more
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Haemophilus parasuis (Glaesserella parasuis) as a Potential Driver of Molecular Mimicry and Inflammation in Rheumatoid Arthritis [PDF]
Frontiers in Medicine, 2021 Background:Haemophilus parasuis (Hps; now Glaesserella parasuis) is an infectious agent that causes severe arthritis in swines and shares sequence similarity with residues 261–273 of collagen type 2 (Coll261−273), a possible autoantigen in rheumatoid arthritis (RA).Objectives/methods: We tested the presence of Hps sequencing 16S ribosomal RNA in ...
Gabriele Di Sante +20 more
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Association between virulence genes and serovars, sequence types of glaesserella (haemophilus) parasuis isolates from the nasal cavity of live piglets [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2022 Th is study analyzed the 19 virulence genes (VGs) of 117 Glaesserella (Haemophilus) parasuis (G. parasuis) isolates from the nasal cavities of live piglets from the south of China and assessed the associations between VGs and serovars, sequence types ...
Ling PENG +4 more
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Exploration of clinical breakpoint of Danofloxacin for Glaesserella parasuis in plasma and in PELF [PDF]
Antibiotics, 2021 Abstract Background To establish the clinical breakpoint (CBP) of danofloxacin to G. parasuis , three cutoff values, including epidemiological cutoff value (ECV), pharmacodynamic cutoff value (CO PD )
Zihui Xu +11 more
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Generation and Evaluation of a Glaesserella (Haemophilus) parasuis Capsular Mutant [PDF]
Infection and Immunity, 2020 Glaesserella ( Haemophilus ) parasuis is a commensal bacterium of the upper respiratory tract in pigs and also the causative agent of Glässer’s disease, which causes significant morbidity and mortality in pigs worldwide.
Kirsten C. Eberle +12 more
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The Glaesserella parasuis phosphoglucomutase is partially required for lipooligosaccharide synthesis [PDF]
Veterinary Research, 2020 AbstractLipooligosaccharides (LOSs) are virulence determinants of Glaesserella parasuis, a pathogen of the respiratory tract of pigs. We previously reported that disruption of the galU or galE gene in G. parasuis results in increased sensitivity to porcine serum, indicating that the galactose catabolism pathway is required for polysaccharide formation ...
Saixiang Feng +7 more
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