Results 31 to 40 of about 787 (149)

Generation and Evaluation of a Glaesserella (Haemophilus) parasuis Capsular Mutant [PDF]

Infection and Immunity, 2020
Glaesserella ( Haemophilus ) parasuis is a commensal bacterium of the upper respiratory tract in pigs and also the causative agent of Glässer’s disease, which causes significant morbidity and mortality in pigs worldwide.
Kirsten C. Eberle, Samantha J. Hau, Shi-Lu Luan, Lucy A. Weinert, Judith A. Stasko, Jinhong Wang, Sarah E. Peters, Paul R. Langford, Andrew N. Rycroft, Brendan W. Wren, Duncan J. Maskell, Alexander W. Tucker, Susan L. Brockmeier   +12 more
openaire   +5 more sources

The Glaesserella parasuis phosphoglucomutase is partially required for lipooligosaccharide synthesis [PDF]

Veterinary Research, 2020
AbstractLipooligosaccharides (LOSs) are virulence determinants of Glaesserella parasuis, a pathogen of the respiratory tract of pigs. We previously reported that disruption of the galU or galE gene in G. parasuis results in increased sensitivity to porcine serum, indicating that the galactose catabolism pathway is required for polysaccharide formation ...
Saixiang Feng, Aihua Chen, Xiaobing Wang, Zhichao Pan, Siqi Xu, Huiwen Yu, Bin Zhang, Ming Liao   +7 more
openaire   +4 more sources

Studying the Interaction of Neutrophils and Glaesserella Parasuis Indicates a Serotype Independent Benefit from Degradation of NETs

Pathogens, 2022
Glaesserella (G.) parasuis is one of the most important porcine pathogens causing Glaesser’s disease. Neutrophil granulocytes are the major counteracting cell type of the innate immune system, which contribute to the host defense by phagocytosis or the ...
Marta C. Bonilla, Simon Lassnig, Andrea Obando Corella, Rabea Imker, Peter Valentin-Weigand, Maren von Köckritz-Blickwede, Anne-Marie Luther, Isabel Hennig-Pauka, Nicole de Buhr   +8 more
doaj   +1 more source

Design of B-Cell Multi-Epitope Subunit Vaccines Against <i>Glaesserella parasuis</i> by Reverse Vaccinology: An In Silico and In Vivo Study. [PDF]

Transbound Emerg Dis
Glässer’s disease caused by Glaesserella parasuis (GPS) is a severe disease that results in substantial economic losses to the swine industry worldwide. Here we describe a multiepitope vaccine cocktail (MEVC) that was designed using reverse vaccinology and immunoinformatics. The MEVC was comprised of three multiepitope subunits (MESs, designated as TB,
Gong Y, Li N, Li Z, Wang H, Zhang D, Chu H, Lu Z, Jia A, Li F, Lei L.   +9 more
europepmc   +2 more sources

Pathotyping and molecular serotyping of clinical isolates of Glaesserella parasuis in Taiwan. [PDF]

Braz J Microbiol
Glaesserella parasuis is a bacterial pathogen that causes severe economic losses in the swine industry worldwide. In this study, 262 G. parasuis isolates from pigs with Glässer's disease obtained between 2015 and 2022 in Taiwan were serotyped, pathotyped, and analyzed for virulence genes. The most prevalent serovars were 5 (29%), 4 (27.9%), 12 (12.2%),
Lin WH, Yen CH, Yang CY, Lin CF, Chang YF, Lin CN, Chiou MT.   +6 more
europepmc   +3 more sources

Importance of strain selection in the generation of heterologous immunity to Glaesserella (Haemophilus) parasuis [PDF]

Veterinary Immunology and Immunopathology, 2021
Glaesserella (Haemophilus) parasuis is a part of the microbiota of healthy pigs and also causes the systemic condition called Glässer's disease. G. parasuis is categorized by it capsular polysaccharide into 15 serovars. Because of the serovar and strain specific immunity generated by whole cell vaccines and the rapid onset of disease, G.
Samantha J. Hau, Kirsten C. Eberle, Susan L. Brockmeier   +2 more
openaire   +2 more sources

Glaesserella parasuis serotype 4 HPS4-YC disrupts the integrity of the swine tracheal epithelial barrier and facilitates bacterial translocation

Veterinary Research, 2021
Glaesserella parasuis (G. parasuis) is a commensal bacterium in the upper respiratory tract of pigs that can also cause the swine Glässer disease, which induces an intensive inflammatory response and results in significant economic losses to the swine ...
Qing Wang, Xiaojing Chang, Mingxing Liu, Qi Lu, Meng Zhu, Huixing Lin, Hongjie Fan   +6 more
doaj   +1 more source

Glaesserella parasuis autotransporters EspP1 and EspP2 are novel IgA-specific proteases

Frontiers in Microbiology, 2022
BackgroundGlaesserella parasuis causes Glässer’s disease, which is associated with severe polyarthritis, fibrinous polyserositis and meningitis, and leads to significant economic losses to the swine industry worldwide. IgA is one of the most important humoral immune factors present on mucosal surfaces, and it plays a crucial role in neutralizing and ...
Zhichao Wang, Zhichao Wang, Jiayun Gu, Jiayun Gu, Kunxue Xiao, Kunxue Xiao, Wenlong Zhu, Wenlong Zhu, Yan Lin, Yan Lin, Siting Wen, Siting Wen, Qigai He, Qigai He, Xiaojuan Xu, Xiaojuan Xu, Xuwang Cai, Xuwang Cai   +17 more
openaire   +3 more sources

Sow Vaccination Against Virulent Glaesserella Parasuis Shapes the Nasal Microbiota of Their Offspring [PDF]

Scientific Reports, 2022
Abstract Glaesserella parasuis is the etiological agent of Glässer’s disease, a common pathology in the pork industry with higher prevalence in the postweaning period. Vaccination is one of the strategies to control this disease. Here, we investigated the effect that sow vaccination against virulent strains of G.
Blanco-Fuertes, Miguel, Correa-Fiz, Florencia, López-Serrano, Sergi, Sibila, Marina, Aragon, Virginia   +4 more
openaire   +5 more sources

Pig nasal and rectal microbiotas are involved in the antibody response to Glaesserella parasuis. [PDF]

Sci Rep
Abstract Vaccination stands as one of the most sustainable and promising strategies to control infectious diseases in animal production. Nevertheless, the causes for antibody response variation among individuals are poorly understood. The animal microbiota has been shown to be involved in the correct development and function of the host ...
Obregon-Gutierrez P, Mahmmod Y, Barba-Vidal E, Sibila M, Correa-Fiz F, Aragón V.   +5 more
europepmc   +6 more sources