Results 71 to 80 of about 787 (149)

Molecular characterization of Glaesserella parasuis strains circulating in North American swine production systems

BMC Veterinary Research, 2023
Abstract Background Glaesserella parasuis is the causative agent of Glässer’s disease in pigs. Serotyping is the most common method used to type G. parasuis isolates.
Mugabi, Robert, Silva, Ana Paula S Poeta, Hu, Xiao, Gottschalk, Marcelo, Aragon, Virginia, Macedo, Nubia R, Sahin, Orhan, Harms, Perry, Main, Rodger, Tucker, Alexander W, Li, Ganwu, Clavijo, Maria J   +11 more
openaire   +5 more sources

Phenotype‐Specific Semi‐Mechanistic Modelling of Florfenicol Time‐Kill Curves in G. Parasuis Compared to Other Respiratory Pathogens

Journal of Veterinary Pharmacology and Therapeutics, Volume 48, Issue 4, Page 318-339, July 2025.
ABSTRACT This study examines the pharmacodynamics (PD) of florfenicol (FFN) for treating porcine respiratory diseases by comparing its effects on Glaesserella parasuis, Actinobacillus pleuropneumoniae and Pasteurella multocida. In vitro time‐kill assays and semi‐mechanistic PD modeling were used to assess bacterial growth and killing rates at varying ...
Andrew Mead, Abigail Hughes, Stefano Azzariti, Pierre‐Louis Toutain, Ludovic Pelligand   +4 more
wiley   +1 more source

Pharmacokinetic–Pharmacodynamic Cutoff Values for Doxycycline in Pigs to Support the Establishment of Clinical Breakpoints for Antimicrobial Susceptibility Testing

Journal of Veterinary Pharmacology and Therapeutics, Volume 48, Issue 4, Page 300-317, July 2025.
ABSTRACT This meta‐analysis provides a population model of doxycycline (DOXY) disposition in pigs for computation of PK/PD cutoff values corresponding to differing modalities of DOXY administration orally in pigs. This analysis enables establishment of specific clinical breakpoints for the development of antimicrobial susceptibility testing of DOXY in ...
Pierre‐Louis Toutain, Alain Bousquet‐Melou, Aude A. Ferran, Béatrice B. Roques, Jérôme R. E. del Castillo, Peter Lees, Siska Croubels, Eric Bousquet, Ludovic Pelligand   +8 more
wiley   +1 more source

Molecular characterization of Glaesserella parasuis strains isolated from North America, Europe and Asia by serotyping PCR and LS-PCR

Veterinary Research, 2021
Glaesserella parasuis strains were characterized by serotyping PCR, vtaA virulence marker Leader Sequence (LS)-PCR, clinical significance, and geographic region. Overall, the serovars 4, 5/12, 7, 1, and 13 were the most commonly detected.
Nubia Macedo, Marcelo Gottschalk, Katrin Strutzberg-Minder, Chao Nguyen Van, Lijun Zhang, Geng Zou, Rui Zhou, Thaire Marostica, Maria Jose Clavijo, Alexander Tucker, Virginia Aragon   +10 more
doaj   +1 more source

Vaccine‐Induced Immune Thrombotic Thrombocytopenia Caused by Zoetis PR‐VAC PLUS in Pseudorabies Virus‐Free Danish Purebred Pigs

Veterinary Medicine and Science, Volume 11, Issue 2, March 2025.
Vaccine‐induced immune thrombotic thrombocytopenia (VITT), a novel syndrome of adverse events following adenovirus vector COVID‐19 vaccines, was observed after vaccination with Zoetis PR‐VAC PLUS. This resulted in 100% morbidity in PRV‐free Danish pure breeders from Danish Genetics Co., causing severe pulmonary oedema, gastric ulcers, haemorrhagic ...
Chien‐Cheng Chen
wiley   +1 more source

Integration of Methylation and Gene Expression Deciphered Candidate Biomarkers DAB2IP and SMYD3 in Delayed Encephalopathy After Carbon Monoxide Poisoning

CNS Neuroscience &Therapeutics, Volume 31, Issue 2, February 2025.
By integrating DNA methylation and gene expression from patients with delayed encephalopathy after carbon monoxide poisoning (DEACMP), this study identified DAB2IP and SMYD3 as candidate genes potentially involved in DEACMP pathogenesis. Additionally, further evidence for their potential as DEACMP targets was provided through pyrosequencing and DEACMP ...
Hongyi Yan, Ding Yuan, Yan Zhang, Haihua Luo, Pinpin Jiang, Yapeng Zhang, Yue Wu, Linlin Hou, Yue Cheng, Fang Yang, Yuqi Du, Huanzhou Zhu, Linshuang Zhao, Yi Li, Yong Jiang, Yanxia Gao   +15 more
wiley   +1 more source

Evaluation of the recombinant proteins RlpB and VacJ as a vaccine for protection against Glaesserella parasuis in pigs

BMC Veterinary Research, 2020
Background Glaesserella parasuis, the causative agent of Glӓsser’s disease, is widespread in swine globally resulting in significant economic losses to the swine industry.
Samantha J. Hau, Shi-Lu Luan, Crystal L. Loving, Tracy L. Nicholson, Jinhong Wang, Sarah E. Peters, David Seilly, Lucy A. Weinert, Paul R. Langford, Andrew N. Rycroft, Brendan W. Wren, Duncan J. Maskell, Alexander W. Tucker, Susan L. Brockmeier, on behalf of the BRaDP1T Consortium   +14 more
doaj   +1 more source

Capsular immunity is necessary for protection against some but not all strains of Glaesserella parasuis.

Vet Microbiol
Glaesserella parasuis is the causative agent of Glässer's disease in pigs and results in significant losses to the swine industry annually. Due to the serovar and strain specific response associated with many bacterin vaccines, there has been difficulty generating broad heterologous protection. Here, an unencapsulated G. parasuis mutant (HS069∆cap) was
Hau SJ, Luan SL, Weinert LA, Langford PR, Rycroft A, Wren BW, Maskell DJ, Tucker AWD, Brockmeier SL.   +8 more
europepmc   +3 more sources

Use of Subtherapeutic Tylvalosin Against Mycoplasma hyopneumoniae: Implications For Respiratory Microbiome Dysbiosis and Swine Lung Health

Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
Enzootic pneumonia (EP) caused by Mycoplasma hyopneumoniae (M. hyopneumoniae) has a significant impact on swine production. Subtherapeutic exposures of tylvalosin in swine, often due to inconsistent dosing in feed or water, promote antimicrobial resistance.
Leonardo Teófilo Toledo, Richard Costa Polveiro, Caio Augustus Diamantino, Gustavo Manoel Rigueira Simão, Carlos Eduardo Real Pereira, Eduardo de Freitas Costa, Maria Aparecida Scatamburlo Moreira, Fernanda Simone Marks, Orhan Sahin   +8 more
wiley   +1 more source

Molecular serotyping of clinical strains of Haemophilus (Glaesserella) parasuis brings new insights regarding Glässer’s disease outbreaks in Brazil [PDF]

PeerJ, 2019
Glässer’s disease (GD) is an important infectious disease of swine caused by Haemophilus (Glaesserella) parasuis. Vaccination with inactivated whole cell vaccines is the major approach for prevention of H.
Julia Pires Espíndola, Natalia Balbinott, Letícia Trevisan Gressler, Gustavo Machado, Catia Silene Klein, Raquel Rebelatto, César Bernardo Gutiérrez Martín, Luiz Carlos Kreutz, Anthony Bernard Schryvers, Rafael Frandoloso   +9 more
doaj   +2 more sources