Results 51 to 60 of about 1,129,384 (247)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Adhesion of Laminated Glass Interlayer in a Double Cantilever Beam Test

Challenging Glass Conference Proceedings
Laminated glass is a key safety element in modern building with glass façades. Tuning the adhesion between the interlayer and the glass as well as the mechanical properties of the interlayer are essentials to both the quality of the laminated glass ...
Paul Elziere, Yael Bronstein, Fabien Levasseur, Francis Serruys   +3 more
doaj   +1 more source

Effects of Composition on the Durability and Weathering of Flat Glass

Challenging Glass Conference Proceedings, 2022
Among the environmental factors affecting glass weathering are humidity, exposure time, temperature, and the presence of pollutants in the atmosphere.
Clarissa Justino de Lima, Brandon Aldinger, Peter de Haan, Telesilla Bristogianni, Fred Veer   +4 more
doaj  

Influence of Temperature on Laminated Glass Performances Assembled with Various Interlayers

Challenging Glass Conference Proceedings, 2016
The increasing demand for use of laminated glass in building facades is the driving force for new interlayers testing and their implementation.
M. Novotny, B. Poot
doaj   +1 more source

Glasses for Glass Electrode

The Journal of the Society of Chemical Industry, Japan, 1958
今日,pHの測定には,ほとんどガラス電極が使用されている現状であり,また,このガラス電極の進歩によって,更に,pH自動制御の可能性が生まれてきた。本研究ではガラス電極用ガラスの性能改良化を目的として,リチウム・ガラス(Li2O含量を26～28mol%に固定)の組成を系統的に変化させ,各ガラス成分のガラス電極特性に及ぼす影響を検討してみた。その結果,ZrO2,CeO2,Al2O3,V2O5,B2O3等の成分で,BaOを置換していくと,いずれもアルカリ誤差の大きくなることがわかった。また,アルカリ誤差の小さいガラスの組成は,SiO259～64mo1%,Li2O26～28mol%,La2O3+ BaO10～13mo1%であった。
Shinzo Okada, Tomota Nishi, Hiroshi Takahashi   +2 more
openaire   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source