Results 61 to 70 of about 669,447 (300)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Physical, structural, optical and thermal investigations of TeO2-modified borate glass for solid-state devices

Results in Physics
The impact of varying TeO2 content (0, 10, and 20 mol%) on the physical, optical, structural, and thermal properties was investigated for Eu2O3 doped borate glasses.
A. Khan, L. Shah, M. Arsalan, Ataullah, I. Khan, M. Shoaib, S.A. Khattak, Tanveer Ahmad, P.M. Ismail, G. Rooh, I. Ullah   +10 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Predicting Composition Dependence of Glass Forming Ability in Ternary Al-Cu-Y System by Thermodynamic Calculation

Metals, 2014
The composition dependence of glass forming ability in the ternary Al-Cu-Y system is predicted by thermodynamic calculations based on the Miedema’s model and Alonso’s method.
Qi Wang, Jiahao Li, Jianbo Liu, Baixin Liu   +3 more
doaj   +1 more source

Bulk metallic glass formation in binary Cu-rich alloy series – Cu100−xZrx (x=34, 36, 38.2, 40 at.%) and mechanical properties of bulk Cu64Zr36 glass [PDF]

, 2004
The compositional dependence of a glass-forming ability (GFA) was systematically studied in a binary alloy series Cu100−xZrx (x=34, 36, 38.2, 40 at.%) by the copper mold casting method. Our results show the critical casting thickness jumps from below 0.5
Duan, Gang, Garland, Carol, Johnson, W. L., Lohwongwatana, Boonrat, Xu, Donghua   +4 more
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Radial dependence of thermal, structural and micro deformation characteristics in Cu-Zr-Al bulk metallic glass subjected to high pressure torsion

Materials & Design
Disk of a Cu38Zr54Al8 bulk metallic glass was subjected to severe plastic deformation by high pressure torsion up to 25 revolutions. X-ray diffraction was utilized to investigate the microstructure of the deformed sample, while the thermal behavior of ...
Talaye Arjmandabasi, Ádám Révész, Viktória K. Kis, Dávid Ugi, Erhard Schafler, Zsolt Kovács   +5 more
doaj   +1 more source

Modeling of the Sub-Tg Relaxation Spectrum of Pd42.5Ni7.5Cu30P20 Metallic Glass [PDF]

, 2016
In this work we study the mechanical relaxation spectrum of Pd42.5Ni7.5Cu30P20 metallic glass. The effect of aging on the relaxation behavior is analyzed by measuring the internal friction during consecutive heating runs.
Chaoren Liu, Daniel Crespo, Eloi Pineda, Jichao Qiao, Liu C., Vogel H.   +5 more
core   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Micro-lateral extrusion of Zr55Cu30Al10Ni5 bulk metallic glass under low-frequency vibration loading

MATEC Web of Conferences, 2015
The effect of vibration on the micro-forming ability of Zr55Cu30Al10Ni5 bulk metallic glass in its supercooled liquid region was studied. The experiment of micro-extrusion was carried out under different amplitude (38 ∼ 760 N) and different frequency (0 ...
Li Jinyang, Zheng Zhizhen, Wu Xiao, Li Jianjun   +3 more
doaj   +1 more source