Results 61 to 70 of about 170,548 (258)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Relation of Structure, Composition and Glass Forming Ability in Zr-Cu Binary Amorphous Alloys
MATEC Web of Conferences, 2016 Molecular dynamics simulation was used to simulate Zr-Cu binary system, in which the relationship between structure, composition and glass forming ability was study.
Dang Yizong, Wang Lu, Fan Qunbo
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Role of bioglass derivatives in tissue regeneration and repair: A review
Reviews on Advanced Materials Science, 2023 Bioceramics are significantly contributing in repairing and reconstructing the defective areas of the musculoskeletal system. Bioactive glass is a non-crystalline bioceramic that has been widely used in regeneration due to its extensive bone-forming ...
Gao Yang +2 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
CALPHAD-enabled design of metallic glasses with target properties: Gold-based glass for jewellery
Materials & DesignThe compositions of current metallic glasses are designed to ensure glass formation, and they can be far from optimal for intended applications. The composition changes needed to improve specific properties can lead to a loss of glass-forming ability ...
Owain S. Houghton +3 more
doaj +1 more source
Results in Physics, 2016 A series of Zr35−xTi30Cu7.5Be27.5Fex (x = 0–10) bulk metallic glasses are cast using water-cooled copper mold casting technique. The glass forming ability (GFA) and thermal stability of Zr35−xTi30Cu7.5Be27.5Fex alloys were studied by means of X-ray ...
Haitao Zong +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Basic thermodynamic and dynamic characteristics of the glass forming intermetallics
Materials & DesignRecent studies on intermetallic glasses challenged the conventional cognition that the glass formability would be deteriorated by the presence of intermetallics.
Ji Wang +8 more
doaj +1 more source