Results 1 to 10 of about 21,105,603 (136)

Glaucocalyxin A suppresses multiple myeloma progression in vitro and in vivo through inhibiting the activation of STAT3 signaling pathway [PDF]

Cancer Cell International, 2021
Background Multiple myeloma (MM) is the most common malignant hematological disease in the people worldwide. Glaucocalyxin A (GLA) is a bioactive ent-kauranoid diterpenoid, that is derived from Rabdosia japonica var. GLA has been demonstrated that it had
Mei Li, Cailong Chen, Qian Wang, Xiaolu Jiang, Lanlan Tan, Ying Huang, Yan Zhang, Zubin Zhang   +7 more
doaj   +3 more sources

Glaucocalyxin A alleviates ulcerative colitis by inhibiting PI3K/AKT/mTOR signaling [PDF]

Scientific Reports
Isodon japonicus (Burm.f.) Hara var. glaucocalyx (Maxim.) Hara is a herbaceous perennial plant. Historically, it has often been used to treat dysentery and other diseases, indicating its potential efficacy in the treatment of inflammatory conditions ...
Tongtong Zhou, Yujing Ye, Weijie Chen, Yanyan Wang, Lulu Ding, Yicun Liu, Leilei Luo, Lixian Wei, Jian Chen, Zhaolian Bian   +9 more
doaj   +3 more sources

Glaucocalyxin A Inhibits the Malignancies of Gastric Cancer Cells by Downregulating MDM2 and RNF6 via MiR-3658 and the SMG1-UPF mRNA Decay Pathway [PDF]

Frontiers in Oncology, 2022
Gastric cancer (GC) ranks as the most common gastrointestinal cancer and is among the leading causes of cancer death worldwide. Glaucocalyxin A (GLA), an entkauranoid diterpene isolated from Rab-dosia japonica var., possesses various bioactivities.
Yanqi Liu, Ping Chen, Daqing Qi, Linhui Chen   +3 more
doaj   +3 more sources

Protective effects of glaucocalyxin A on the airway of asthmatic mice [PDF]

Open Medicine, 2022
The aim of this study is to investigate the protective effects of glaucocalyxin A (GLA) on airways in mouse models of asthma, concerning the inflammatory mediators, Th1/Th2 subgroup imbalance, and Toll-like receptor 4 (TLR4)/NF-κB signaling pathway ...
Chen Si, Piao Ying, Song Yilan, Wang Zhiguang, Jiang Jingzhi, Piao Yihua, Li Li, Xu Chang, Li Liangchang, Chi Yongxue, Jin Guihua, Yan Guanghai   +11 more
doaj   +3 more sources

Glaucocalyxin A Inhibits the Malignant Progression of Epithelial Ovarian Cancer by Affecting the MicroRNA-374b-5p/HMGB3/Wnt-β-Catenin Pathway Axis [PDF]

Frontiers in Oncology, 2022
ObjectiveGlaucocalyxin A (GLA) is an ent-kaurene diterpenoid from Rabdosia japonica var possessing anti-tumor activity. This study aimed to investigate effects of GLA on epithelial ovarian cancer (EOC) and elucidate underlying mechanisms.MethodsThe ...
Feng Chen, Feng Chen, Fang Sun, Xia Liu, Jing Shao, Bei Zhang, Bei Zhang   +6 more
doaj   +3 more sources

Glaucocalyxin A delays the progression of OA by inhibiting NF-κB and MAPK signaling pathways [PDF]

Journal of Orthopaedic Surgery and Research
Background Osteoarthritis (OA) is a common degenerative joint condition marked by inflammation and cartilage breakdown. Currently, there is a dearth of treatment medications that can clearly slow the course of OA.
Xin Hong, Xuqiang Liu, Bo Li, Shoujie Shi, Kai Xiao, Tiantian Xu, Yaoyang Nie, Min Dai, Meisong Zhu   +8 more
doaj   +3 more sources

Glaucocalyxin A Protects H9c2 Cells Against Hypoxia/Reoxygenation-Induced Injury Through the Activation of Akt/Nrf2/HO-1 Pathway [PDF]

Cell Transplantation, 2020
Myocardial infarction (MI) is one of the most serious cardiovascular diseases associated with myocardial ischemia/reperfusion (I/R) injury. Glaucocalyxin A (GLA) is a biologically active ent-kauranoid diterpenoid that has been found to ameliorate ...
Zhuo Peng, Rui Zhang, Longfei Pan, Honghong Pei, Zequn Niu, Hai Wang, Junhua Lv, Xiaoyan Dang   +7 more
doaj   +3 more sources

Glaucocalyxin A alleviates lipopolysaccharide-induced inflammation and apoptosis in pulmonary microvascular endothelial cells and permeability injury by inhibiting STAT3 signaling. [PDF]

Exp Ther Med, 2022
Glaucocalyxin A (GLA), an ent-kauranoid diterpene derived from Rabdosia japonica var. glaucocalyx, possesses antibacterial, anti-oxidative and anti-neuroinflammatory properties.
Cao J, Liu M, Feng S, Li Y, Zheng K.
europepmc   +2 more sources

Glaucocalyxin A Attenuates IL-1β-Induced Inflammatory Response and Cartilage Degradation in Osteoarthritis Chondrocytes via Inhibiting the Activation of NF-κB Signaling Pathway. [PDF]

Dis Markers, 2022
Glaucocalyxin A (GLA) is a bioactive natural compound with anti-inflammatory activity. Herein, the role of GLA in osteoarthritis (OA) was evaluated. Our results demonstrated that the IL-1β-induced inducible nitric oxide synthase (iNOS) and cyclooygenase ...
Zhu W, Zhang Y, Li Y, Wu H.
europepmc   +2 more sources

Glaucocalyxin B Alleviates Lipopolysaccharide-Induced Parkinson’s Disease by Inhibiting TLR/NF-κB and Activating Nrf2/HO-1 Pathway [PDF]

Cellular Physiology and Biochemistry, 2017
Background/Aims: Parkinson’s disease (PD) is a common neurodegenerative disease in the old population, characterized by dopaminergic neuron loss, inflammation and oxidative stress injury in the substantia nigra.
Wei Xu, Deyu Zheng, Yuanyuan Liu, Ji Li, Li Yang, Xiuli Shang   +5 more
doaj   +3 more sources