Food Frontiers, 2023 Chronic obstructive pulmonary disease (COPD) is an irreversible disease with the leading causes of morbidity, mortality, and several physical limitations. Isodon Suzhouensis is a unique Chinese medicinal plant used for both medicine and food.
Kefeng Zhai +10 more
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Glaucocalyxin A Attenuates Allergic Responses by Inhibiting Mast Cell Degranulation through p38MAPK/NrF2/HO-1 and HMGB1/TLR4/NF-κB Signaling Pathways. [PDF]
Evid Based Complement Alternat Med, 2021 Glaucocalyxin A (GLA) has various pharmacological effects like antioxidation, immune regulation, and antiatherosclerosis. Here, in this study, the effect and mechanism of GLA on mast cell degranulation were studied.
Piao Y +10 more
europepmc +3 more sources
An Up-to-Date Review of Traditional Chinese Medicine in the Treatment of Atherosclerosis: Components, Mechanisms, and Therapeutic Potentials. [PDF]
Phytother ResAtherosclerosis is a chronic inflammatory disease and a major global health concern. In recent years, traditional Chinese medicines (TCMs) have demonstrated multi-target therapeutic potential against atherosclerosis by modulating inflammatory responses ...
Nijat D +5 more
europepmc +4 more sources
Preparation, optimization of the inclusion complex of glaucocalyxin A with sulfobutylether-β-cyclodextrin and antitumor study [PDF]
Drug Delivery, 2019 Glaucocalyxin A (GLA), is a diterpenoid extracted from Hara and has been studied for decades for its diverse bioactivities. However, GLA presents poor solubility in water and low bioavailability through oral administration which has hindered its ...
Lili Ren, Jingjing Wang, Guoguang Chen
doaj +4 more sources
Glaucocalyxin A Ameliorates Hypoxia/Reoxygenation-Induced Injury in Human Renal Proximal Tubular Epithelial Cell Line HK-2 Cells. [PDF]
Int J Mol Sci, 2021 Ischemia-reperfusion injury is one of the major causes of acute kidney injury (AKI), which is increasingly prevalent in clinical settings. Glaucocalxin A (GLA), a biologically ent-kauranoid diterpenoid, has various pharmacological effects like ...
Hosohata K, Jin D, Takai S.
europepmc +5 more sources
Glaucocalyxin A exerts anticancer effect on osteosarcoma by inhibiting GLI1 nuclear translocation via regulating PI3K/Akt pathway. [PDF]
Cell Death Dis, 2018 Osteosarcoma, the most common malignant bone tumor with recurring disease or lung metastases, has become one of the leading causes of death in humans. In the current study, we made an investigation on the anticancer effect of glaucocalyxin A, a bioactive
Zhu J +8 more
europepmc +5 more sources
Glaucocalyxin A inhibits platelet activation and thrombus formation preferentially via GPVI signaling pathway. [PDF]
PLoS ONE, 2013 Platelets play a pivotal role in atherothrombosis and the antiplatelet agents have been proved to be useful in preventing onset of acute clinical events including myocardial infarction and stroke.
Wei Li +9 more
doaj +4 more sources
Evidence-Based Complementary and Alternative Medicine, Volume 2014, Issue 1, 2014., 2014 Rabdosia japonica var. glaucocalyx (Maxim.) Hara, belonging to the Labiatae family, is widely used as an anti-inflammatory and antitumor drug for the treatment of different inflammations and cancers. Aim of the Study.
Chun-jun Chu +7 more
core +3 more sources
Glaucocalyxin A alleviates inflammatory response in rats with traumatic fracture [PDF]
Jichu yixue yu linchuangObjective To investigate whether glaucocalyxin A can reduce inflammatory response in rats with traumatic fracture. Methods The rats were randomly divided into control group, model group, low GLA (GLA-L), high GLA dose group (GLA-H) and GLA-H+YC-1 (HIF ...
JIANG Bowen, MA Rui, WANG Peng, QU Zhe, LI Aiqun
doaj +2 more sources
Comparative transcriptome analysis of roots, stems and leaves of Isodon amethystoides reveals candidate genes involved in Wangzaozins biosynthesis [PDF]
BMC Plant Biology, 2018 Background Isodon amethystoides (Ben-th) Cy Wu et Hsuan is an important traditional medicinal plant endowed with pharmacological properties effective in the treatment of various diseases, including pulmonary tuberculosis.
Fenglan Zhao +9 more
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