Results 111 to 120 of about 3,631,478 (254)

Ukrain modulates glial fibrillary acidic protein, but not connexin 43 expression, and induces apoptosis in human cultured glioblastoma cells

, 2007
Glioblastoma is a highly malignant tumor, characterized by an unfavorable prognosis even in response to multidisciplinary treatment strategies, owing to its high-invasive phenotype.
W. Nowicky, I. Magnani, C. Moscheni, C. Torri, M. Gioia, N. Gagliano, E. Donetti, F. Costa   +7 more
core   +1 more source

Harnessing Aggregation‐Induced Emission for Advanced Disease Diagnosis: Mechanisms, Strategies and Future Perspectives

Medicine Bulletin, EarlyView.
The figure was created in BioRender.com. ABSTRACT Accurate and early diagnosis remains a key challenge in modern disease management. Conventional diagnostic methods often suffer from limitations in sensitivity, spatial resolution, and practical usability.
Zizhuo Du, Li Song, Xingrui Chen, Jun Jing, Yingchen Wang, Yue Jiang, Jiahui Gao, Dan Li, Feiran Xie, Peihong Xiao, Ben Zhong Tang   +10 more
wiley   +1 more source

Fibroblasts can express glial fibrillary acidic protein (GFAP) in vivo.

, 2001
Neuropathologists use anti-glial fibrillary acidic protein (GFAP) antibodies as specific markers for glial cells, and neurobiologists use GFAP for targeting transgenes to glial cells.
Voigtländer, T, Mazal, P R, Budka, H, Maddalena, A S, Hainfellner, J A, Ströbel, T, Aguzzi, A; https://orcid.org/   +6 more
core   +1 more source

High‐Fat Diet Exacerbates Neuropathology in a Transgenic Mouse Model of Multiple System Atrophy

Movement Disorders, EarlyView.
Abstract Background Multiple system atrophy (MSA) is a rare and devastating neurodegenerative disorder. Accumulating clinical and preclinical evidence suggests that diabetes and insulin resistance may adversely influence MSA pathophysiology. Objective We investigated the potential association between diabetes, impaired glucose homeostasis, and MSA ...
Marie‐Laure Arotcarena, Anna Delamarre, Miguel Lopez‐Cuina, Hugo Martin, Elio Balpe, Xavier Fioramonti, Erwan Bezard, Wassilios G. Meissner   +7 more
wiley   +1 more source

COVID‐19 Amplifies Sex‐Specific Dopamine and Glial Responses in a Parkinson's Disease Mouse Model

Movement Disorders, EarlyView.
Abstract Background Exposure to environmental agents, including viral infections, may increase Parkinson's disease (PD) susceptibility, especially in males, but the neurodegenerative risk extent of COVID‐19 remains uncertain. Objectives We investigated the plausible link between severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and
Ifeoluwa Awogbindin, Mélanie Bourque, Marc Morissette, Marie‐Ève Hamelin, Chantal Rhéaume, Jared VanderZwaag, Antonia Landwehr, Disha Patel, Guy Boivin, Marie‐Ève Tremblay, Thérèse Di Paolo   +10 more
wiley   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source

Retinal functional alterations in mice lacking intermediate filament proteins glial fibrillary acidic protein and vimentin.

, 2015
Vimentin (Vim) and glial fibrillary acidic protein (GFAP) are important components of the intermediate filament (IF) (or nanofilament) system of astroglial cells.
Wunderlich, K.A., Grosche, Antje, Zrenner, Eberhart, Perez, Maria‐Thereza, Tanimoto, Naoyuki, Zrenner, E., Grosche, A., Pannicke, Thomas, Pekny, Milos,, Wunderlich, Kirsten A., Tanimoto, N., Pannicke, T., Seeliger, Mathias W, Seeliger, Mathias W., Perez, Maria Thereza,, Wunderlich, Kirsten, Reichenbach, A., Perez, M.-T, Seeliger, M.W., Lund University., Pekny, Milos, Reichenbach, Andreas, Perez, Maria Thereza, Wunderlich, Kirsten,   +23 more
core   +1 more source

Hinokitiol Promotes Neural Repair After Spinal Cord Injury by Reprogramming Microglial Inflammatory and Redox Responses

Phytotherapy Research, EarlyView.
Schematic illustration showing that Hinokitiol promotes neural repair after spinal cord injury by activating the Keap1/Nrf2/HO‐1 signaling pathway and reprogramming microglial inflammatory‐redox responses. ABSTRACT Secondary neuroinflammation and oxidative stress, driven partly by maladaptive microglial activation, limit recovery after spinal cord ...
Wenhao Zhang, Jing Wang, Tianyi Wang, Qihao Fu, Jiawen Xu, Chaochen Li, Zheng Zhou, Chenxi Zhang, Guanhua Xu, Mingjie Xia, Zhiming Cui   +10 more
wiley   +1 more source

3082 Glial fibrillary acidic protein astrocytopathy (GFAP-A): two Australian cases highlight the clinical heterogeneity

3082 Glial fibrillary acidic protein astrocytopathy (GFAP-A): two Australian cases highlight the clinical ...
Mustafa Al-Musawi (20210703), Alex A Chen (20210709), Matthew Shrimpton (13086123), Abhishek A Malhotra (20210706)   +3 more
core