Results 101 to 110 of about 70,938 (290)

Intraoperative electroacupuncture relieves remifentanil-induced postoperative hyperalgesia via inhibiting spinal glial activation in rats

Molecular Pain, 2017
Background Accumulating studies have suggested that remifentanil, the widely-used opioid analgesic in clinical anesthesia, can activate the pronociceptive systems and enhance postoperative pain.
Changxi Shi, Yue Liu, Wei Zhang, Yishan Lei, Cui’e Lu, Rao Sun, Yu’e Sun, Ming Jiang, Xiaoping Gu, Zhengliang Ma   +9 more
doaj   +1 more source

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

Animal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao, Chunlan Zou, Junxian Li, Yang Yang, Yuanyuan Han, Tingyu Ke   +5 more
wiley   +1 more source

Glial Fibrillary Acidic Protein (GFAP): Neuroinflammation Biomarker in Acute Ischemic Stroke

Journal of Inflammation Research, 2021
Lisda Amalia Department of Neurology, The First Affiliated Hospital of Faculty of Medicine, Universitas Padjadjaran/RSUP dr. Hasan Sadikin, Bandung, IndonesiaCorrespondence: Lisda Amalia Jl.Pasteur 38, Bandung, 40161, IndonesiaEmail dr.lisda@gmail ...
Amalia L
doaj  

Quantitative proteomic profiling of the rat substantia nigra places glial fibrillary acidic protein at the hub of proteins dysregulated during aging: Implications for idiopathic Parkinson’s disease

, 2020
There is a strong correlation between aging and onset of idiopathic Parkinson’s disease, but little is known about whether cellular changes occur during normal aging that may explain this association.
Gates, M, Shirran, L, Fuller, H, Synowsky, S, Gómez-Gálvez, Y   +4 more
core   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Cardiopulmonary-Bypass Glial Fibrillary Acidic Protein Correlates With Neurocognitive Skills

, 2018
Neuro-cognitive deficits at school starting age may affect as many as 50% of children who underwent cardiac surgery for complex congenital heart diseases (CHD).
Falasco, Gianclaudio, Suppiej, Agnese, Vedovelli, Luca, Simonato, Manuela, Manuela Simonato, Padalino, Massimo, Cogo, Paola, Virgilio P. Carnielli, Giovanni Stellin, Gianclaudio Falasco, Paola Cogo, Stellin, Giovanni, Luca Vedovelli, Massimo Padalino, Carnielli, Virgilio P., Stefano Sartori, Sartori, Stefano, Carnielli, Virgilio P, Agnese Suppiej   +18 more
core   +1 more source

From Marginal to Central: Marginal Zone‐like B Cells as Critical Targets in Cladribine‐Treated Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Multiple sclerosis (MS) is a chronic autoimmune disease where B cells play a central pathogenic role. Cladribine, an oral therapy, provides durable benefits by reshaping lymphocyte populations, yet its specific long‐term impact on distinct B‐cell subsets is not fully understood.
Marta Pirronello, Mario Picozza, Gisella Guerrera, Silvia Corbisiero, Andrea Misiti, Roberta C. Placido, Alice Verdiani, Lorenzo de Marco, Manolo Sambucci, Elena Olivieri, Daniela F. Angelini, Esmeralda Quartuccio, Luca Prosperini, Carla Tortorella, Maria C. Buscarinu, Valeria Zancan, Francesca de Masi, Marco Salvetti, Claudio Gasperini, Giovanna Borsellino, Luca Battistini   +20 more
wiley   +1 more source

Elevated vitreous body glial fibrillary acidic protein in retinal diseases [PDF]

, 2015
Purpose: Increased expression of glial fibrillary acidic protein (GFAP) is a characteristic of gliotic activation (Müller cells and astrocytes) in the retina.
Cord Huchzermeyer, Grieb, P, Rejdak, K, Rejdak, R, Maciejewski, R, Juenemann, AGM, Zrenner, E., Robert Rejdak, Anselm Gerhard Maria Jünemann, Petzold, A.F.S., Huchzermeyer, C, Petzold, A, Rejdak, K., Zrenner, E, Pawel Grieb, Eberhart Zrenner, Friedrich E. Kruse, Maciejewski, R., Grieb, P., Konrad Rejdak, Kruse, F.E., Rejdak, R., Ryszard Maciejewski, Huchzermeyer, C., Axel Petzold, Kruse, FE, Junemann, A.G.M.   +26 more
core   +1 more source

Atomically precise metal cluster enzymes for pathological tissue regeneration

BMEMat, EarlyView.
Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong, Zhifeng Shi, Mengqing Li, Jien Han, Haoyan Chen, Maofei Ran, Shaojian Zhong, Limin Ma, Chengyun Ning, Youzhun Fan, Zhenghua Tang, Peng Yu   +11 more
wiley   +1 more source

Characterization of the transient middle cerebral artery occlusion model of ischemic stroke in a HuR transgenic mouse line

Data in Brief, 2018
This set of experiments characterizes a model of transient cerebral ischemic stroke in a transgenic (Tg) mouse line in which the glial fibrillary acidic protein (GFAP) promoter is utilized to drive expression of a human RNA-binding protein, HuR ...
A. Ardelt, R. Carpenter, I. Iwuchukwu, A. Zhang, W. Lin, E. Kosciuczuk, C. Hinkson, T. Rebeiz, S. Reitz, P. King   +9 more
doaj   +1 more source