Results 81 to 90 of about 70,938 (290)

Glial Protein Mutations in Alexander Disease

Pediatric Neurology Briefs, 2005
The role of glial fibrillary acidic protein (GFAP) mutations in Alexander disease was analyzed in 44 patients, including 18 with later onset, at the University of Alabama, Birmingham, AL, and at other centers in the US, UK and Europe.
J Gordon Millichap
doaj   +1 more source

Role of bone morphogenetic protein-2/4 in astrocyte activation in neuropathic pain

Molecular Pain, 2019
Background Bone morphogenetic protein-2/4 (BMP2/4) has been recognized as promoters of astrocyte activity. Substantial evidence suggests that BMP2/4 may be elevated and plays a critical role in astrocyte activation upon spinal cord injury.
Lin Yang, Shuxin Liu, Yaping Wang
doaj   +1 more source

Aberrant E-cadherin, beta-catenin, and glial fibrillary acidic protein (GFAP) expression in canine choroid plexus tumors [PDF]

, 2011
Expression of E-cadherin and beta-catenin has been widely studied in various human and canine epithelial tumors and has been correlated with dedifferentiation, invasiveness, and metastasis.
Higgins, Robert J., Francey, Thierry, Zurbriggen, Andreas, Robert J. Higgins, Doherr, Marcus, Oevermann, Anna, Marcus Doherr, Nentwig, Alice, Thierry Francey, Alice Nentwig, Andreas Zurbriggen, Anna Oevermann   +11 more
core   +1 more source

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

Specificity of the glial fibrillary acidic protein for astroglia.

, 1977
Glial fibrillary acidic protein (GFA) is the main constituent of glial filaments and the close similarity of GFA and neurofilament protein has been recently reported.
D Dahl, A Bignami
core   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Glial fibrillary acidic protein and S100b protein immunoreactivity in the hippocampus of weaning rats from dams treated with acrylamide during pregnancy

Acrylamide is formed at high temperature during preparation of food rich in carbohydrates. It can be found in animal feed based on potatoes and granulated wheat subjected to thermal treatment.
Siemowit Muszyński, Ewa Tomaszewska, Aleksandra E. Krawczyk, Karol Rycerz, Jadwiga Jaworska-Adamu, Piotr Dobrowolski, Marcin Arciszewski   +6 more
core   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Spinal astrocytic activation contributes to mechanical allodynia in a rat model of cyclophosphamide-induced cystitis

Molecular Pain, 2016
Background Previous studies have demonstrated that glial cells play an important role in the generation and maintenance of neuropathic pain. Activated glial cells produce numerous mediators such as proinflammatory cytokines that facilitate neuronal ...
Bolong Liu MD, PhD, Minzhi Su MD, ShaoJun Tang PhD, Xiangfu Zhou MD, PhD, Hailun Zhan MD, Fei Yang MD, Wenbiao Li MD, Tengcheng Li MD, Juncong Xie MD   +8 more
doaj   +1 more source

Effects of Hypothermia on S100B and Glial Fibrillary Acidic Protein in Asphyxia Rats After Cardiopulmonary Resuscitation

, 2014
The aim of the study was to investigate the effects of hypothermia on S100B and glial fibrillary acidic protein (GFAP) in serum and hippocampus CA1 area in asphyxiated rats after cardiopulmonary resuscitation (CPR).
Xinwen Bai, Zhang, YB, Jianming Hao, Xiaomin Lin   +3 more
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