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Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy
JAMA Neurology, 2016A novel astrocytic autoantibody has been identified as a biomarker of a relapsing autoimmune meningoencephalomyelitis that is immunotherapy responsive. Seropositivity distinguishes autoimmune glial fibrillary acidic protein (GFAP) meningoencephalomyelitis from disorders commonly considered in the differential diagnosis.To describe a novel IgG ...
Boyan, Fang +6 more
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Cell-free synthesis of glial fibrillary acidic protein
Neurochemical Research, 1980Glial fibrillary acidic (GFA) protein has been synthesized in an RNA-dependent cell-free system derived from rabbit reticulocytes. The cell-free synthesized product appears to have the same size as GFA protein isolated from bovine spinal cord, thus showing that GFA protein does not undergo detectable proteolytic processing.
P, Béguin, E M, Shooter, L F, Eng
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Dynamics of bovine glial fibrillary acidic protein phosphorylation
Neuroscience Letters, 1996Recently, the dynamic features of the intermediate filaments (IF) have been revealed. The effect of phosphorylation on the dynamics of bovine glial fibrillary acidic protein (GFAP), the astroglial IF, was studied in vitro with fluorescently labeled GFAP.
Y, Nakamura, M, Takeda, T, Nishimura
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Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy
Neurology India, 2023Yuxin, Deng, Mingguo, Xie, Lichuan, Zeng
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Phosphorylation of the glial fibrillary acidic protein
Journal of Neuroscience Research, 1990AbstractThe glial fibrillary acidic protein (GFAP) was found to be phosphorylated in vivo after intracerebral injection of [32P]‐orthophosphate, in brain Slices, and in a cell free system. The phosphorylated proteins were separated by two‐dimensional gel electrophoresis and then transferred to nitrocellulose sheets.
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Glial Fibrillary Acid Protein in Medulloblastomas
1983Glial Fibrillary Acid Protein (GFAP) is regarded as an astroglial-specific component and its presence can therefore be used to control the degree of differentiation of glial elements (BIGNAMI and DAHL, 1974; 1977). This method is being used with increasing frequency in neuro-oncology, with some contradictory results, however (for review see De ARMOND ...
E. Schindler, F. Gullotta
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Glial fibrillary acidic protein and related glial proteins as biomarkers of neurotoxicity
Expert Opinion on Drug Safety, 2005A variety of '-omic' technologies are being increasingly applied in preclinical safety assessments. Such approaches, however, have not been implemented in neurotoxicity safety evaluations. Current regulatory guidelines for assessing neurotoxicity emphasise reliance on traditional histopathological stains and behavioural testing batteries.
James P, O'Callaghan, Krishnan, Sriram
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Glial Fibrillary Acidic Protein in Hepatic Encephalopathy
Journal of Neuropathology & Experimental Neurology, 1981Basal ganglia, thalamus, cerebral cortex, and subcortical white matter were studied in ten cases of hepatic encephalopathy (HE), including three cases of acquired hepatocerebral degeneration (HCD), and in thirteen age-matched controls using the peroxidase-antiperoxidase immunohistochemical staining technique for glial fibrillary acidic (GFA) protein ...
R A, Sobel +3 more
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Autoimmune encephalitis in glial fibrillary acidic protein astrocytopathy
BMJ Case ReportsAutoimmune encephalitis due to glial fibrillar acidic protein (GFAP) astrocytopathy is a rare cause of subacute neuropsychiatric changes. In this case, a young patient presented with a viral prodrome and meningismus, followed by progressive encephalopathy and movement disorders over the span of 2 weeks.
Charlie Weige Zhao +3 more
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[The glial fibrillary acidic protein].
Presse medicale (Paris, France : 1983), 1991Since it was discovered, twenty years ago, the glial fibrillary acidic protein has been the subject of more than 500 publications. The huge interest it has raised up is probably due partly to its abundance in the central nervous system and also, above all, to its cellular specificity which makes it the universally recognized marker of astrocytes.
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