Results 201 to 210 of about 3,631,478 (254)

Mechanically Compliant, Precision‐Porous Brain Implants Reduce the Foreign Body Reaction and Guide Regeneration

Advanced Healthcare Materials, Volume 15, Issue 33, 4 September 2026.
This study explores how the brain responds to implants of different properties. Hydrogels with various mechanical properties and pore sizes were implanted in adult rat brains. It is observed that hydrogels with mechanical property closely matched to the brain and 40 µm pore size elicit a pro‐healing response from the brain by modulating the immune ...
Ian Dryg, Le Zhen, Rebecca Darrow, Savannah Lawton, Lars Crawford, Robert Robinson, Steve Perlmutter, James D. Bryers, Buddy D. Ratner   +8 more
wiley   +1 more source

Neurofluid Biomarker Sensors: Integrated Design Strategies From Molecular Recognition to Precision Neurological Diagnosis

Advanced Sensor Research, Volume 5, Issue 9, September 2026.
This review focuses on the principles and signal mechanisms of four types of neurofluid biomarker sensors (electrochemical, optical, mechanical, and multimodal), summarizes the detection strategies for biomarkers such as ions, neurotransmitters, metabolites, and inflammatory proteins and their applications in the diagnosis and treatment of neurological
Ting Li, Guoying Pan, Yuheng Wang, Xin Zou, Hui Yang   +4 more
wiley   +1 more source

Diagnostic and Prognostic Value of Serum Glial Fibrillary Acidic Protein in Acute Ischemic Stroke. [PDF]

J Clin Med
Agnello L, Ciaccio AM, Del Ben F, Daidone M, Pacinella G, Masucci A, Tamburello M, Gambino CM, Tuttolomondo A, Ciaccio M.   +9 more
europepmc   +1 more source

Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation

Advanced Science, Volume 13, Issue 50, 7 September 2026.
A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou, Inês Afonso Martins, Ismail Amr El‐Shimy, Iacopo Bicci, Donatella Cea, Christina Bukas, Isra Mekki, Mara‐Camelia Rusu, Aylin Nebol, Ines Lahmann, Marie Piraud, Enrico Klotzsch, Mina Gouti   +12 more
wiley   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Plasma Glial Fibrillary Acidic Protein (GFAP) shows age-dependent associations with externalizing psychopathology and atypical brain connectivity. [PDF]

Transl Psychiatry
Niveditha BS, Holla B, Subramanian S, Gagana N, Bhargavi KM, Sharma E, Mahadevan J, Purushottam M, Viswanath B, Benegal V, Arunachal G, Heron J, Hickman M, Basu D, Subodh BN, Singh L, Singh R, Kumaran K, Kuriyan R, Kurpad SS, Kartik K, Kalyanram K, Desrivieres S, Barker G, Papadopoulos Orfanos D, Toledano MB, Murthy P, Vaidya N, Krishnaveni G, Schumann G, Sharma KK, Bhaskarapillai B, Thennarasu K, Kashyap R, Bharath RD, Chakrabarti A, Chetan GK, Srinivas Bharath MM.   +37 more
europepmc   +1 more source

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu, Jiarong Yang, Miaoxuan Zhang, Yi Li, Zhuling Tu, Ji Wang, Jin‐Tai Yu, Kun Guo, Rongcan Luo   +8 more
wiley   +1 more source

Plasma neurofilament light chain and glial fibrillary acidic protein in the differential diagnosis of acute vertigo in the emergency department. [PDF]

J Neurol
Haidegger M, Berger N, Fandler-Höfler S, Gattermeyer-Kell L, Hatab I, Kneihsl M, Monsberger S, Niedrist T, Tafrali C, Martinez-Serrat M, Benkert P, Kuhle J, Enzinger C, Khalil M, Gattringer T.   +14 more
europepmc   +1 more source

Closed‐Loop Decoding and Intervention of Pain: A Novel BMI Strategy Integrating θ‐Band Detection and Mechano‐Electro‐Biological Coupled Hydrogels

Advanced Science, Volume 13, Issue 52, 18 September 2026.
A closed‐loop brain–machine interface with a PFAPT hydrogel electrode identifies prefrontal θ‐band as a neuropathic pain biomarker. The hydrogel enables stable 28 d ECoG recording and delivers θ‐triggered cortical stimulation, alleviating pain and affective behaviors in rats via bidirectional regulation of inflammation and central sensitization ...
Yun Ji, Tao Li, Guoqiang Lei, Huichun Luo, Xiuqian Guo, Jiao Xiang, Tao Shi, Weitang Liu, Yuxin Zhang, Xiaoyu Liao, Shutao Zhao, Jiayun Wu, Wangao Zhang, Wenhui Liu, Chuanglong He, Shuo Chen, Tao Wu, Ke Ma   +17 more
wiley   +1 more source