Results 211 to 220 of about 3,631,478 (254)

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source

α‐Synuclein Aggregate‐Disassembling Compounds Prolong Survival in a Mouse Model of Parkinson's Disease

Aggregate, Volume 7, Issue 9, September 2026.
All‐D peptides that bind monomeric α‐synuclein shift the aggregation equilibrium, dismantle pathogenic fibrils, and suppress seeding activity in vitro and in cells. In a Parkinson's disease mouse model, treatment delays disease progression and extends survival, supporting direct aggregate disassembly as a disease‐modifying therapeutic strategy for ...
Sara Reithofer, Marc Sevenich, Madita Vollmer, Dila Kurtul, Laura Müller, Pelin Özdüzenciler, Laurin Gerhards, Kira Allmeroth, Mathias Wendt, Fahimeh Charbgoo, Sarah Schemmert, Marcel Naumann, Karolina Korostov, Gina Hartmann, Lothar Gremer, Gültekin Tamgüney, Dieter Willbold, Antje Willuweit   +17 more
wiley   +1 more source

Predictive value of apparent diffusion coefficient, plasma levels of placental growth factor and glial fibrillary acidic protein, and their combinations for patients with recurrent glioblastoma. [PDF]

Discov Oncol
Yin Y, Deng S, Zhang Z, Tang W.
europepmc   +1 more source

Are infraslow oscillations the missing link between sleep and Alzheimer's?

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Locus coeruleus (LC) and glymphatic dysfunction have been linked both to Alzheimer's disease (AD) and, recently, to infraslow oscillation (ISO) in sleep spindle (sigma) activity (ISO). Here we hypothesize ISO integrity is a critical link between sleep and AD.
Demetrio Grollero, Victoria Gabb, Jonathan Blackman, Amanda Heslegrave, Luisa de Vivo, Elizabeth Coulthard, Michele Bellesi   +6 more
wiley   +1 more source

Neurofilament light chain and glial fibrillary acidic protein as biomarkers of peripheral nervous system involvement in multiple sclerosis: diagnostic and prognostic evaluation. [PDF]

BMC Neurol
Flintere-Flinte A, Krutovs V, Pantelejeva E, Blennow K, Zetterberg H, Zolovs M, Kenina V.   +6 more
europepmc   +1 more source

Cross‐tissue immune profiling of APOE ε4 reveals early dysregulation in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Apolipoprotein E (APOE) ε4 is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD), but its contribution to disease pathogenesis remains incompletely understood. METHODS Here, we integrate proteomic profiling of plasma (n = 9028), cerebrospinal fluid (n = 1099), dorsolateral prefrontal cortex (n = 720), and ...
Artur Shvetcov, Shannon Thomson, Mark E. Graham, Brittany Hauger, Jessica E. Keller, Christine J. Smoyer, Sarah E. Tague, Ann‐Na Cho, Farhad B. Imam, Varsha Krish, Global Neurodegeneration Proteomics Consortium (GNPC), Matthew K. Taylor, Jonathan D. Mahnken, Debra K. Sullivan, Joanne H. Reed, Jeffrey M. Burns, Chad Slawson, Russell H. Swerdlow, Heather M. Wilkins, Caitlin A. Finney   +19 more
wiley   +1 more source

Investigation of Prognostic Factors in Patients With Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy. [PDF]

Eur J Neurol
Kimura A, Takekoshi A, Maekawa Y, Tanaka K, Yamano Y, Saito K, Takemura M, Shimohata T.   +7 more
europepmc   +1 more source

Incidence of dementia and mild cognitive impairment in two Indigenous Bolivian cohorts

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION We studied dementia incidence and risk factors in Indigenous Tsimane and Moseten Amerindian populations in Amazonian Bolivia with largely subsistence lifestyles. METHODS A median of 4.7 years after baseline dementia assessment, 730 participants (52% male; mean age 67.3 years) were re‐visited at two follow‐up phases to determine ...
Margaret Gatz, Wendy J. Mack, Daniel Eid Rodriguez, Raul Quispe Gutierrez, Jesus Bani Cuata, Helena C. Chui, Ellen E. Walters, Daniel K. Cummings, Paul L. Hooper, Henrik Zetterberg, Caleb E. Finch, Benjamin C. Trumble, Jonathan Stieglitz, Michael D. Gurven, Randall C. Thompson, Gregory S. Thomas, The HORUS Team, Tsimane Health and Life History Project, Hillard S. Kaplan   +18 more
wiley   +1 more source

Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer's disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in the hippocampal dentate gyrus subgranular cell zone (SGZ) of 5×FAD mice was measured using ...
Weiqi Sun, Biyu Yang, Hanyuan Zheng, Qi Wang, Yajiao Shi, Gandig Wang, Wang Yin, Hui Wang, Xuetao Qi, Yun Yao, Jiaxin Wang, Shuang Cui, Kun Cui, Jian Mao, Yiyuan Xia, Jianwen Deng, Siyuan Zhao, Zhihao Wang, Fengyu Liu, Ming Yi, Jiuyang Ding, Weidong Le, Xinyan Li, Junliang Yuan, You Wan, Jie Zheng   +25 more
wiley   +1 more source