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Glial fibrillary acidic protein and related glial proteins as biomarkers of neurotoxicity
Expert Opinion on Drug Safety, 2005A variety of '-omic' technologies are being increasingly applied in preclinical safety assessments. Such approaches, however, have not been implemented in neurotoxicity safety evaluations. Current regulatory guidelines for assessing neurotoxicity emphasise reliance on traditional histopathological stains and behavioural testing batteries.
James P O’Callaghan
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Glial fibrillary acidic protein antibody-positive meningoencephalomyelitis
Practical Neurology, 2018 Glial fibrillary acidic protein antibody-positive meningoencephalomyelitis is a newly described, possibly under-recognised, severe inflammatory condition of the nervous system. The clinical presentation is variable but most commonly is a combination of meningitis, encephalitis and myelitis; other manifestations may include seizures, psychiatric ...
Angeliki Zarkali +5 more
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An ELISA for glial fibrillary acidic protein
Journal of Immunological Methods, 2004Glial fibrillary acidic protein (GFAP) is the major intermediate filament protein of the astrocyte, and body fluid levels of GFAP are an important tool for estimating astrogliosis and astrocytic activation in vivo. This paper presents a new sandwich ELISA allowing quantification of GFAP(SMI26) from the cerebrospinal fluid (CSF).
A, Petzold +4 more
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Glial fibrillary acidic protein in medulloblastoma
Acta Neuropathologica, 1981Twenty-four cases of classical medulloblastoma and one case of desmoplastic medulloblastoma were examined for glial fibrillary acidic protein (GFAP) using the immunoperoxidase method to assess astrocytic differentiation. In 16 cases of classical medulloblastoma GFAP-positive cells were present in variable numbers.
H, Mannoji +4 more
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Glial fibrillary acidic protein in medulloblastomas
Acta Neuropathologica, 1985Two cases of medulloblastoma are described which show positive immunostaining for glial fibrillary acidic protein (GFAP) in many cells. The surgical and autopsy specimens were examined by the indirect immunoperoxidase method. Positive staining for GFAP was demonstrated in the small, round to polygonal cells in both surgical specimens and in the small ...
T, Kumanishi +3 more
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Neurology, 2018
Intermediate filaments are a fundamental component of the cytoskeleton in neurons and astrocytes. The main intermediate filament in astrocytes is glial fibrillary acid protein (GFAP). Like other intermediate filaments, GFAP interacts with other components of the cytoskeleton, adhesion molecules, intracellular chaperones, and other proteins.
Andrew, McKeon, Eduardo E, Benarroch
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Intermediate filaments are a fundamental component of the cytoskeleton in neurons and astrocytes. The main intermediate filament in astrocytes is glial fibrillary acid protein (GFAP). Like other intermediate filaments, GFAP interacts with other components of the cytoskeleton, adhesion molecules, intracellular chaperones, and other proteins.
Andrew, McKeon, Eduardo E, Benarroch
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Glial Fibrillary Acidic Protein
Developmental Neuroscience, 2007The differentiation of tanycytes during development of the mouse hypothalamus has been followed by immunohistochemistry with a GFA protein antiserum. Radially oriented processes of the tanycytes were stained with GFA antiserum in the ventral and the dorsal lining of the third ventricle in the mouse neonate and at later ages.
Françoise Vitry +3 more
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