Results 101 to 110 of about 11,735 (173)

Rapid Progression of Gliomatosis Cerebri to Secondary Glioblastoma, Factors That Affect the Progression Rate: A Case Report

대한영상의학회지, 2017
Glioblastomas may develop de novo or through progression from low-grade or anaplastic astrocytomas. The term ‘primary glioblastoma’ refers to a glioblastoma that lacks a precursor lesion and has a clinical history of less than three months.
Hee Kyung Kim, In Kyu Yu, Seung Min Kim, Joo Heon Kim, Seung Hoon Lee, Seung Yeon Lee   +5 more
doaj   +1 more source

3-D Convolutional Neural Networks for Glioblastoma Segmentation [PDF]

arXiv, 2016
Convolutional Neural Networks (CNN) have emerged as powerful tools for learning discriminative image features. In this paper, we propose a framework of 3-D fully CNN models for Glioblastoma segmentation from multi-modality MRI data. By generalizing CNN models to true 3-D convolutions in learning 3-D tumor MRI data, the proposed approach utilizes a ...
arxiv  

GRP78 Nanobody‐Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy

Advanced Science, EarlyView.
A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang, Runhua Zhou, Chengchao Xu, Lingyun Dai, Rui Hou, Liuhai Zheng, Chunjin Fu, Guangwei Shi, Jingwei Wang, Yang Li, Jinpeng Cen, Xiaolong Xu, Le Yu, Yilei Li, Jigang Wang, Qingfeng Du, Zhijie Li   +16 more
wiley   +1 more source

RNF112 Facilitates Ubiquitin‐Mediated Degradation of c‐Myc, Suppressing Proliferation, Migration and Lipid Synthesis in Bladder Cancer

Advanced Science, EarlyView.
RNF112, an E3 ubiquitin ligase, is markedly reduced in bladder cancer (BLCA). It curbs BLCA cell proliferation, migration, and lipid production primarily by enhancing ubiquitin‐dependent degradation of c‐Myc. This degradation inhibits c‐Myc's role in upregulating ACLY, a crucial enzyme for lipid synthesis, highlighting RNF112's potential as a ...
Kangping Xiong, Siming Chen, Huimin Xu, Sheng Tu, Hong Weng, Yejinpeng Wang, Mingxing Li, Jingtian Yu, Kaiyu Qian, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Gang Wang   +13 more
wiley   +1 more source

TRAF3IP3 Induces ER Stress‐Mediated Apoptosis with Protective Autophagy to Inhibit Lung Adenocarcinoma Proliferation

Advanced Science, EarlyView.
Schematic diagram of the working model of TRAF3IP3 in the coordination of ER stress and autophagy related apoptosis in lung cancer cells. Abstract TNF receptor‐associated factor 3 interacting protein 3 (TRAF3IP3/T3JAM) exhibits dual roles in cancer progression. While upregulated in most malignancies and critical for immune regulation.
Guang Zhao, Jun Qi, Fang Li, Haotian Ma, Rui Wang, Xiuyi Yu, Yufei Wang, Sida Qin, Jie Wu, Chen Huang, Hong Ren, Boxiang Zhang   +11 more
wiley   +1 more source

The Novel Dual GIP and GLP‐1 Receptor Agonist Tirzepatide Attenuates Colon Cancer Development by Regulating Glucose Metabolism

Advanced Science, EarlyView.
Tirzepatide, a dual GIP/GLP‐1 receptor agonist for diabetes, suppresses colorectal cancer growth by targeting glucose metabolism. It inhibits cancer cell proliferation, promotes apoptosis, and induces tumor regression. It reduces glucose uptake and destabilizes HIF‐1α for degradation to downregulate PFKFB3/PFK‐1 enzymes, thus contributing to the ...
Yikai Zhang, Yi Xie, Shenglong Xia, Xinnuo Ge, Jiaying Li, Fang Liu, Fan Jia, Shengyao Wang, Qiao Zhou, Menghan Gao, Weihuan Fang, Chao Zheng   +11 more
wiley   +1 more source

Tumoroid Model Reveals Synergistic Impairment of Metabolism by Iron Chelators and Temozolomide in Chemo‐Resistant Patient‐derived Glioblastoma Cells

Advanced Science, EarlyView.
This study investigates the metabolic vulnerabilities of glioblastoma (GBM), an aggressive brain tumor. Research demonstrates that iron chelation therapy, in combination with standard chemotherapy, significantly enhances the efficacy of treatment against resistant GBM cells in a 3D tumoroid model.
Meitham Amereh, Amir Seyfoori, Shahla Shojaei, Sarah Lane, Tian Zhao, Mahdieh Shokrollahi Barough, Julian J. Lum, Patrick Walter, Mohsen Akbari   +8 more
wiley   +1 more source

The Super Enhancer‐Driven Long Noncoding RNA PRKCQ‐AS1 Promotes Neuroblastoma Tumorigenesis by Interacting With MSI2 Protein and Is Targetable by Small Molecule Compounds

Advanced Science, EarlyView.
PRKCQ‐AS1 is overexpressed due to transcriptional super‐enhancers. PRKCQ‐AS1 RNA forms a complex with MSI2 protein to induce BMX mRNA stabilization and overexpression, ERK protein phosphorylation and neuroblastoma cell proliferation. Compound NSC617570 blocks PRKCQ‐AS1 binding to MSI2, leading to BMX mRNA disassociation from MSI2 protein, BMX reduction,
Sujanna Mondal, Pei Y. Liu, Janith Seneviratne, Antoine De Weck, Pooja Venkat, Chelsea Mayoh, Jing Wu, Jesper Maag, Jingwei Chen, Matthew Wong, Nenad Bartonicek, Poh Khoo, Lei Jin, Louise E. Ludlow, David S. Ziegler, Toby Trahair, Pieter Mestdagh, Belamy B. Cheung, Jinyan Li, Marcel E. Dinger, Ian Street, Xu D. Zhang, Glenn M. Marshall, Tao Liu   +23 more
wiley   +1 more source

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source

Postoperative glioblastoma segmentation: Development of a fully automated pipeline using deep convolutional neural networks and comparison with currently available models [PDF]

arXiv
Accurately assessing tumor removal is paramount in the management of glioblastoma. We developed a pipeline using MRI scans and neural networks to segment tumor subregions and the surgical cavity in postoperative images. Our model excels in accurately classifying the extent of resection, offering a valuable tool for clinicians in assessing treatment ...
arxiv