Results 41 to 50 of about 222,357 (321)

Glioblastoma

Archives of Pathology & Laboratory Medicine, 2007
Abstract Context.—Glioblastoma (GBM), the most common primary intracranial malignancy, is a morphologically diverse neoplasm with dismal prognosis despite multimodality therapy. Only 3 distinct morphologic variants of GBM are currently recognized by the current World Health Organization classification scheme, including GBM, giant cell ...
C. Ryan Miller, Arie Perry
openaire   +3 more sources

MicroRNA-29a activates a multi-component growth and invasion program in glioblastoma

Journal of Experimental & Clinical Cancer Research, 2019
Background Glioblastoma is a malignant brain tumor characterized by rapid growth, diffuse invasion and therapeutic resistance. We recently used microRNA expression profiles to subclassify glioblastoma into five genetically and clinically distinct ...
Yun Zhao, Wei Huang, Tae-Min Kim, Yuchae Jung, Lata G. Menon, Hongyan Xing, Hongwei Li, Rona S. Carroll, Peter J. Park, Hong Wei Yang, Mark D. Johnson   +10 more
doaj   +1 more source

Theoretical analysis for a PDE-ODE system related to a Glioblastoma tumor with vasculature [PDF]

, 2020
In this paper we study a PDE-ODE system as a simplification of a Glioblastoma model. Mainly, we prove the existence and uniqueness of global in time classical solution using a fixed point argument. Moreover, we show some stability results of the solution depending on some conditions on the parameters.
arxiv   +1 more source

Treatment of Glioblastoma [PDF]

Journal of Oncology Practice, 2017
Glioblastoma is the most common and most aggressive form of primary brain tumor in adults and contributes to high social and medical burden as a result of its incurable nature and significant neurologic morbidity. Despite ongoing research, there has not been improvement in survival in glioblastoma.
Joo Yeon Nam, John de Groot
openaire   +3 more sources

Inhibition of Intercellular Cytosolic Traffic via Gap Junctions Reinforces Lomustine-Induced Toxicity in Glioblastoma Independent of MGMT Promoter Methylation Status

Pharmaceuticals, 2021
Glioblastoma is a malignant brain tumor and one of the most lethal cancers in human. Temozolomide constitutes the standard chemotherapeutic agent, but only shows limited efficacy in glioblastoma patients with unmethylated O-6-methylguanine-DNA ...
Matthias Schneider, Anna-Laura Potthoff, Bernd O. Evert, Marius Dicks, Denise Ehrentraut, Andreas Dolf, Elena N. C. Schmidt, Niklas Schäfer, Valeri Borger, Torsten Pietsch, Mike-Andrew Westhoff, Erdem Güresir, Andreas Waha, Hartmut Vatter, Dieter H. Heiland, Patrick Schuss, Ulrich Herrlinger   +16 more
doaj   +1 more source

Identification of prognostic values defined by copy number variation, mRNA and protein expression of LANCL2 and EGFR in glioblastoma patients

Journal of Translational Medicine, 2021
Background Epidermal growth factor receptor (EGFR) and lanthionine synthetase C-like 2 (LanCL2) genes locate in the same amplicon, and co-amplification of EGFR and LANCL2 is frequent in glioblastoma.
Hua-fu Zhao, Xiu-ming Zhou, Jing Wang, Fan-fan Chen, Chang-peng Wu, Peng-yu Diao, Lin-rong Cai, Lei Chen, Yan-wen Xu, Jing Liu, Zong-yang Li, Wen-lan Liu, Zhong-ping Chen, Guo-dong Huang, Wei-ping Li   +14 more
doaj   +1 more source

The Role of NKT Cells in Glioblastoma

Cells, 2021
Glioblastoma is an aggressive and deadly cancer, but to date, immunotherapies have failed to make significant strides in improving prognoses for glioblastoma patients.
Emily E. S. Brettschneider, Masaki Terabe   +1 more
doaj   +1 more source

Artificial Intelligence Solution for Effective Treatment Planning for Glioblastoma Patients [PDF]

arXiv, 2022
Glioblastomas are the most common malignant brain tumors in adults. Approximately 200000 people die each year from Glioblastoma in the world. Glioblastoma patients have a median survival of 12 months with optimal therapy and about 4 months without treatment.
arxiv  

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Implication of tumor morphology and MRI characteristics on the accuracy of automated versus human segmentation of GBM areas

Scientific Reports
An assessment scheme is proposed to evaluate GBM gross tumor core and T2-FLAIR hyper-intensity segmentations on preoperative multicentric MR images as a function of tumor morphology and MRI characteristics.
Valeria Cerina, Chiara Benedetta Rui, Andrea Di Cristofori, Davide Ferlito, Giorgio Carrabba, Carlo Giussani, Gianpaolo Basso, Elisabetta De Bernardi   +7 more
doaj   +1 more source