Results 1 to 10 of about 49,717 (158)

The Role of Selenoproteins SELENOM and SELENOT in the Regulation of Apoptosis, ER Stress, and Calcium Homeostasis in the A-172 Human Glioblastoma Cell Line

Biology, 2022
It is known that seven mammalian selenoproteins are localized in the endoplasmic reticulum: SELENOM, SELENOT, SELENOF, SELENOK, SELENOS, SELENON, and DIO2.
Elena G. Varlamova, Michael V. Goltyaev, Egor A. Turovsky   +2 more
doaj   +4 more sources

Development and validation of a machine learning-based survival prediction model for Asian glioblastoma patients using the SEER database and Chinese data [PDF]

Scientific Reports
Glioblastoma is an aggressive, malignant primary brain tumour and the most prevalent histological type of glioma. Our study attempted to investigate the independent predictors of overall survival (OS) and cancer-specific survival (CSS) in Asian patients ...
Denglin Li, Luxin Zhang, Lifei Xu, Renhe Zhai, Hanyu Gao, Junlan Gao, Minghai Wei, Ningwei Che, Yeting He   +8 more
doaj   +3 more sources

Protective potential of piroxicam on human peripheral blood mononuclear cells against the suppressive capacity of glioblastoma cell lines

Scientific Reports, 2022
Dexamethasone, a common medication used in the treatment regimen of glioblastoma, has broad inhibitory effects on the immune responses. Here, in an in vitro study, we examined the effects of piroxicam, a potent substitute for dexamethasone, on peripheral
Jahangir Abdesheikhi, Farnaz Sedghy, Alireza Farsinejad, Merat Mahmoudi, Mahdi ranjkesh, Meysam Ahmadi-Zeidabadi   +5 more
doaj   +2 more sources

Phenoxazine derivatives induce caspase-independent cell death in human glioblastoma cell lines, A-172 and U-251 MG

Oncology Reports, 2007
The apoptotic effects of 2-amino-4,4alpha-dihydro-4alpha, 7-dimethyl-3H-phenoxazine-3-one (Phx-1) and 2-aminophenoxazine-3-one (Phx-3) on human glioblastoma cell lines, A-172 and U-251 MG were studied. These phenoxazines extensively decreased the viability of A-172 and U-251 MG cells (IC50 of Phx-1: 60 microM, in both lines; IC50 of Phx-3: 10 and 3 ...
Ken, Shirato, Kazuhiko, Imaizumi, Akihisa, Abe, Akio, Tomoda   +3 more
openaire   +4 more sources

Lichen Secondary Metabolites Inhibit the Wnt/β-Catenin Pathway in Glioblastoma Cells and Improve the Anticancer Effects of Temozolomide

Cells, 2022
Lichens are a source of secondary metabolites with significant pharmacological potential. Data regarding their possible application in glioblastoma (GBM) treatment are, however, scarce.
Aleksandra Majchrzak-Celińska, Robert Kleszcz, Elżbieta Studzińska-Sroka, Agnieszka Łukaszyk, Anna Szoszkiewicz, Ewelina Stelcer, Karol Jopek, Marcin Rucinski, Judyta Cielecka-Piontek, Violetta Krajka-Kuźniak   +9 more
doaj   +2 more sources

Evaluation of the Cytotoxic Effects of Ciprofloxacin on Human Glioblastoma A-172 Cell Line

Middle East Journal of Cancer, 2017
Background: Glioblastoma multiforme, the most common, aggressive malignant brain tumor which affects patients of all ages, is principally resistant to treatment. Ciprofloxacin is an antibiotic that belongs to the fluoroquinolones.
Ashkan Zandi, Taraneh Moini Zanjani, Seyed Ali Ziai, Yalda Khazaei Poul, Mostafa Haji Molla Hoseini   +4 more
doaj   +1 more source

The Synergistic Effects of the Combination of Ciprofloxacin and Temozolomide on Human Glioblastoma A-172 Cell Line

Middle East Journal of Cancer, 2017
Background: Combination therapy has generated remarkable motivation in the clinical setting since it boosts the therapeutic potential of anticancer drugs.
Ashkan Zandi, Taraneh Moini Zanjani, Seyed Ali Ziai, Yalda Khazaei Poul, Mostafa Haji Molla Hoseini   +4 more
doaj   +1 more source

Xanthone-1,2,4-triazine and Acridone-1,2,4-triazine Conjugates: Synthesis and Anticancer Activity

Pharmaceuticals, 2023
A total of 21 novel xanthone and acridone derivatives were synthesized using the reactions of 1,2,4-triazine derivatives with 1-hydroxy-3-methoxy-10-methylacridone, 1,3-dimethoxy-, and 1,3-dihydroxanthone, followed by optional dihydrotiazine ring ...
Sougata Santra, Ainur D. Sharapov, Ramil F. Fatykhov, Anastasya P. Potapova, Igor A. Khalymbadzha, Maria I. Valieva, Dmitry S. Kopchuk, Grigory V. Zyryanov, Alexander S. Bunev, Vsevolod V. Melekhin, Vasiliy S. Gaviko, Andrey A. Zonov   +11 more
doaj   +1 more source

Mechanism of Ca²⁺-Dependent Pro-Apoptotic Action of Selenium Nanoparticles, Mediated by Activation of Cx43 Hemichannels

Biology, 2021
To date, there are practically no data on the mechanisms of the selenium nanoparticles action on calcium homeostasis, intracellular signaling in cancer cells, and on the relationship of signaling pathways activated by an increase in Ca2+ in the cytosol ...
Egor A. Turovsky, Elena G. Varlamova
doaj   +1 more source

The Toxicity of Synthetic and Biogenic Selenium Nanoparticles on Human Brain Glioblastoma Cell Line: An in vitro Comparison [PDF]

International Journal of Medical Toxicology and Forensic Medicine, 2020
Background: Brain tumors can be serious and life-threatening when they are treated effectively. Many therapeutic approaches, such as chemotherapy, radiotherapy, and surgery have been used to treat brain tumors.
Shideh Khangholi, Mehdi Mahdavi, Mohammad Hossein Yazdi, Ahmad Reza Shahverdi   +3 more
doaj   +1 more source