Results 11 to 20 of about 49,717 (158)

Bis-Bibenzyls from the Liverwort Pellia endiviifolia and Their Biological Activity

Plants, 2021
Based on previous investigations where bis-bibenzyls isolated from liverworts showed various biological activities (cytotoxic, antimicrobial, and antiviral), we investigated their cytotoxic activity in several human cancer cell lines.
Ivana Ivković, Miroslav Novaković, Milan Veljić, Marija Mojsin, Milena Stevanović, Petar D. Marin, Danka Bukvički   +6 more
doaj   +1 more source

Antioxidant and Cytotoxic Activities of Kudzu Roots and Soy Molasses against Pediatric Tumors and Phytochemical Analysis of Isoflavones Using HPLC-DAD-ESI-HRMS

Plants, 2022
Pediatric solid tumors (PSTs) are life-threatening and can lead to high morbidity and mortality rates in children. Developing novel remedies to treat these tumors, such as glioblastoma multiforme and sarcomas, such as osteosarcoma, and rhabdomyosarcoma ...
Saied A. Aboushanab, Vadim A. Shevyrin, Grigory P. Slesarev, Vsevolod V. Melekhin, Anna V. Shcheglova, Oleg G. Makeev, Elena G. Kovaleva, Ki Hyun Kim   +7 more
doaj   +1 more source

Comparative Study of the Anticancer Effects of Selenium Nanoparticles and Selenium Nanorods: Regulation of Ca²⁺ Signaling, ER Stress and Apoptosis

Applied Sciences, 2023
The anti-cancer effects of selenium sources are well known. Among other things, selenium has been shown to have a pleiotropic effect, causing cancer cell death without affecting the healthy cell’s viability, or, in the case of brain cells, has a ...
Elena G. Varlamova, Ilya V. Baimler, Sergey V. Gudkov, Egor A. Turovsky   +3 more
doaj   +1 more source

A 2,5-Dihydroxybenzoic Acid–Gelatin Conjugate Inhibits the Basal and Hsp90-Stimulated Migration and Invasion of Tumor Cells

Journal of Functional Biomaterials, 2020
The extracellular cell surface-associated and soluble heat shock protein 90 (Hsp90) is known to participate in the migration and invasion of tumor cells.
Anastasiya V. Snigireva, Oleg S. Morenkov, Yuri Y. Skarga, Alexander V. Lisov, Zoya A. Lisova, Alexey A. Leontievsky, Mariya A. Zhmurina, Viktoria S. Petrenko, Veronika V. Vrublevskaya   +8 more
doaj   +1 more source

Targeted intracellular delivery of resveratrol to glioblastoma cells using apolipoprotein E-containing reconstituted HDL as a nanovehicle. [PDF]

PLoS ONE, 2015
The objective of this study is to transport and deliver resveratrol to intracellular sites using apolipoprotein E3 (apoE3). Reconstituted high-density lipoprotein (rHDL) bearing resveratrol (rHDL/res) was prepared using phospholipids and the low-density ...
Sea H Kim, Birendra Babu Adhikari, Siobanth Cruz, Michael P Schramm, Joe A Vinson, Vasanthy Narayanaswami   +5 more
doaj   +1 more source

The Effect of 5-aza,2’-deoxyCytidine (5 AZA CdR or Decitabine) on Extrinsic, Intrinsic, and JAK/STAT Pathways in Neuroblastoma and Glioblastoma Cells Lines

Asian Pacific Journal of Cancer Prevention, 2023
Epigenetic changes such as histone deacetylation and DNA methylation play to regulate gene expression. DNA methylation plays a major role in cancer induction via transcriptional silencing of critical regulators such as tumor suppressor genes (TSGs).
M. Sanaei, F. Kavoosi
semanticscholar   +1 more source

P10.34.B ONCOGENIC ASPP2KAPPA(K), A DOMINANT-NEGATIVE ISOFORM OF THE APOPTOSIS STIMULATING PROTEIN OF P53-2 (ASPP2) PROMOTES CLASSICAL HALLMARKS OF CANCER IN GLIOBLASTOMA

Neuro-Oncology, 2023
GB is the most common, most aggressive primary brain tumor with a deleterious prognosis. ASPP2 is a tumor suppressor, directly interacting with p53.
M. Hafner, A. Ruiba, L. Kampa, I. Sommer, A. Ahrens, V. Kälin, A. Zeitlberger, K. Buchauer, L. Plasswilm, T. Hundsberger, M. Neidert, M. Schittenhelm, K. Kampa-Schittenhelm   +12 more
semanticscholar   +1 more source

CK2 Inhibition and Antitumor Activity of 4,7-Dihydro-6-nitroazolo[1,5-a]pyrimidines

Molecules, 2022
Today, cancer is one of the most widespread and dangerous human diseases with a high mortality rate. Nevertheless, the search and application of new low-toxic and effective drugs, combined with the timely diagnosis of diseases, makes it possible to cure ...
Daniil N. Lyapustin, Svetlana K. Kotovskaya, Ilya I. Butorin, Evgeny N. Ulomsky, Vladimir L. Rusinov, Denis A. Babkov, Alexander A. Pokhlebin, Alexander A. Spasov, Vsevolod V. Melekhin, Maria D. Tokhtueva, Anna V. Shcheglova, Oleg G. Makeev   +11 more
doaj   +1 more source

Synthesis of silver nanoparticles using Salvia officinalis extract: Structural characterization, cytotoxicity, antileishmanial and antimicrobial activity [PDF]

Nanomedicine Research Journal, 2020
Objective: This study aimed to investigate the cytotoxicity, antileishmanial and antibacterial potential of silver nanoparticles (AgNPs) synthesized by (Salvia officinalis L. (Sage)) extract.
Fatemeh Sharifi, Fariba Sharififar, Sara Soltanian, Mohsen Doostmohammadi, Neda Mohamadi   +4 more
doaj   +1 more source

Lichen-Derived Compounds and Extracts as Biologically Active Substances with Anticancer and Neuroprotective Properties

Pharmaceuticals, 2021
Lichens are a source of chemical compounds with valuable biological properties, structurally predisposed to penetration into the central nervous system (CNS).
Elżbieta Studzińska-Sroka, Aleksandra Majchrzak-Celińska, Przemysław Zalewski, Dominik Szwajgier, Ewa Baranowska-Wójcik, Barbara Kaproń, Tomasz Plech, Marcin Żarowski, Judyta Cielecka-Piontek   +8 more
doaj   +1 more source