Results 91 to 100 of about 261,478 (313)

Sex differences in genomics, immune microenvironment and immunotherapy response in adult grade 4 gliomas

Clinical and Translational Discovery
Purpose Sex differences in the prevalence of gliomas have been reported; however, whether there are sex differences in the development and immunotherapy of gliomas remains poorly understood.
Feng Tang, Zhen‐Yuan Liu, Xi Chen, Jin‐Zhou Yang, Zhi‐Qiang Li   +4 more
doaj   +1 more source

GLIOMA OF THE BRAIN [PDF]

The Journal of Nervous and Mental Disease, 1908
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openaire   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Glioma-associated mutations identified in cell lines used in this study.

, 2018
Glioma-associated mutations identified in cell lines used in this study.
Mindy K. Graham (5759450), Alan K. Meeker (150313), Anthony J. Rizzo (5759453), David M. Esopi (217110), Charles G. Eberhart (150132), Christine Davis (5759459), Christopher M. Heaphy (5759465), Jacqueline A. Brosnan-Cashman (5759447), Ming Yuan (90012), Rebecca Zhang (2862509), Eric H. Raabe (5759462), Kaylar M. Myers (5759456)   +11 more
core   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Glioma-associated region co-localizes with a selective sweep.

, 2016
A view of the most associated region for glioma (A) and inspection of minor allele frequencies shows that low minor allele frequencies (indicative of selection) in breeds related to an ancestral Bulldog (B) co-localize with the associated region.
Kartika Jayashankar (546862), Danika Bannasch (102080), Anqi Xiong (3171186), Karin Forsberg-Nilsson (145089), Erik Bongcam-Rudloff (168047), Katarina Truvé (215968), Peter Dickinson (251910), Göran Andersson (87442), Kerstin Lindblad-Toh (11607), Michele Koltookian (688331), Gerli Pielberg (411805), Hans-Henrik Fuxelius (47018), Daniel York (760708), Fredrik J. Swartling (3171180), Åke Hedhammar (157748), Eva Murén (467077), Holger Weishaupt (3171183)   +16 more
core   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Serum beta2-microglobulin acts as a biomarker for severity and prognosis in glioma patients: a preliminary clinical study

BMC Cancer
Background Gliomas are the deadliest malignant tumors of the adult central nervous system. We previously discovered that beta2-microglobulin (B2M) is abnormally upregulated in glioma tissues and that it exerts a range of oncogenic effects.
Zhen-Yuan Liu, Feng Tang, Jing Wang, Jin-Zhou Yang, Xi Chen, Ze-Fen Wang, Zhi-Qiang Li   +6 more
doaj   +1 more source

Molecular and clinical characterization of TIM-3 in glioma through 1,024 samples

OncoImmunology, 2017
Background: Researches on immunotherapy of glioma has been increasing exponentially in recent years. However, autoimmune-like side effects of current immune checkpoint blockade hindered the clinical application of immunotherapy in glioma.
Guanzhang Li, Zheng Wang, Chuanbao Zhang, Xing Liu, Jinquan Cai, Zhiliang Wang, Huimin Hu, Fan Wu, Zhaoshi Bao, Yanwei Liu, Liang Zhao, Tingyu Liang, Fan Yang, Ruoyu Huang, Wei Zhang, Tao Jiang   +15 more
doaj   +1 more source

MicroRNA-based chemoresistance in glioblastoma

Glioma, 2019
Glioblastoma (GBM) is the most common malignant tumor of the central nervous system in adults. GBM is characterized by violent invasion and poor prognosis.
Zhenghui Ma, Huandi Zhou, Qing Chang, Xiaoying Xue   +3 more
doaj   +1 more source