Results 91 to 100 of about 382,034 (365)

Comprehensive RNAseq analysis reveals PIK3CD promotes glioblastoma tumorigenesis by mediating PI3K-Akt signaling pathway

Glioma, 2020
Background and Aim: Glioblastoma (GBM) is the most common and aggressive form of primary malignant brain tumors. Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta (PIK3CD), which is overexpressed in GBM, is involved in GBM ...
Zulfikar Azam, Wei Shao, Ho-keung Ng, Jing Wang, Zhong-ping Chen, Shing-shun Tony To   +5 more
doaj   +1 more source

Research progress of drug resistance mechanisms to temozolomide in glioblastoma: A narrative review

Glioma, 2022
Glioblastoma multiforme (GBM) is the most common malignant tumor in the adult central nervous system, and surgery combined with radiotherapy and chemotherapy represents the main treatment regimens.
Allen Lu
doaj   +1 more source

Malignant astrocytic glioma: genetics, biology, and paths to treatment.

Genes & Development, 2007
Malignant astrocytic gliomas such as glioblastoma are the most common and lethal intracranial tumors. These cancers exhibit a relentless malignant progression characterized by widespread invasion throughout the brain, resistance to traditional and newer ...
F. Furnari, T. Fenton, R. Bachoo, A. Mukasa, Jayne M. Stommel, A. Stegh, W. Hahn, K. Ligon, D. Louis, C. Brennan, L. Chin, R. DePinho, W. Cavenee   +12 more
semanticscholar   +1 more source

Are Gliomas Preventable?

European Journal of Cancer Supplements, 2006
Gliomas are a family of primary central nervous system tumors of variable malignancy that are derived from supporting glia (astrocytes, oligodendrocytes, ependymal cells) or their progenitors/stem cells. There are two potential strategies to prevention: preventing gliomas from forming and preventing lower-grade gliomas from developing into higher-grade
openaire   +2 more sources

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source

HIF-1α and HIF-2α: synergistic regulation of glioblastoma malignant progression during hypoxia and apparent chemosensitization in response to hyperbaric oxygen

Cancer Cell International
Glioblastoma multiforme (GBM), the most malignant type of brain tumour, is regulated mainly by a hypoxic microenvironment. Previous studies have focused mainly on the effects of hypoxia inducible factor-1α (HIF-1α) or hypoxia inducible factor-2α (HIF-2α)
Pan Wang, Sheng Gong, Bin Liao, Jie Liu, Lu Zhao, Nan Wu   +5 more
doaj   +1 more source

Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma

Frontiers in Pharmacology
BackgroundThis study investigates whether Hypoxia-Inducible Factor 1 alpha (HIF1α) and Hypoxia-Inducible Factor 2 alpha (HIF2α) coordinately regulate insulin-like growth factor 1 receptor (IGF1R) expression, thereby influencing chemosensitivity in ...
Bin Liao, Bin Liao, Pan Wang, Sheng Gong, Lu Zhao, Lu Zhao, Jie Liu, Jie Liu, Nan Wu, Nan Wu   +9 more
doaj   +1 more source

Surgical resection of glioma involving eloquent brain areas: Tumor boundary, functional boundary, and plasticity consideration

Glioma, 2020
Glioma is the most refractory intracranial tumor, and its diffuse infiltrative growth characteristics make total resection impossible in a biological sense, especially when tumors invade eloquent brain areas.
Yu Lin, Xuejun Yang
doaj   +1 more source

Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors

New England Journal of Medicine, 2015
BACKGROUND The prediction of clinical behavior, response to therapy, and outcome of infiltrative glioma is challenging. On the basis of previous studies of tumor biology, we defined five glioma molecular groups with the use of three alterations ...
J. Eckel-Passow, D. Lachance, A. Molinaro, K. Walsh, P. Decker, H. Sicotte, M. Pekmezci, T. Rice, M. Kosel, I. Smirnov, G. Sarkar, Alissa A. Caron, T. Kollmeyer, Corinne E. Praska, A. Chada, C. Halder, H. Hansen, L. McCoy, P. Bracci, Roxanne E Marshall, S. Zheng, G. Reis, Alexander R. Pico, B. O’Neill, J. Buckner, C. Giannini, J. Huse, A. Perry, T. Tihan, M. Berger, Susan M. Chang, M. Prados, J. Wiemels, J. Wiencke, M. Wrensch, R. Jenkins   +35 more
semanticscholar   +1 more source

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source