Results 101 to 110 of about 382,034 (365)
Cancer Cell InternationalBackground Glioblastoma multiforme (GBM) is highly malignant, and hypoxia often exacerbates its aggressiveness. The aim of this study was to explore the molecular mechanism by which miR-652-5p promoter hypermethylation augments the malignancy of ...
Pan Wang +6 more
doaj +1 more source
Tumor growth patterns in central nervous system tumors with astrocytic differentiation
Glioma, 2020 Background and Aim: Glial tumors with astrocytic differentiation are the most common primary malignant brain tumors. Hans Joachim Scherer established histological criteria based on hematoxylin and eosin (H&E) staining, which form the basis of the World ...
Emran Myumyun Lyutfi +3 more
doaj +1 more source
CSF-1R inhibition alters macrophage polarization and blocks glioma progression
Nature Medicine, 2013 Glioblastoma multiforme (GBM) comprises several molecular subtypes, including proneural GBM. Most therapeutic approaches targeting glioma cells have failed.
S. Pyonteck +19 more
semanticscholar +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou +16 more
wiley +1 more source
Pediatric low-grade glioma in the era of molecular diagnostics
Acta Neuropathologica Communications, 2020 Low grade gliomas are the most frequent brain tumors in children and encompass a spectrum of histologic entities which are currently assigned World Health Organisation grades I and II. They differ substantially from their adult counterparts in both their
S. Ryall, U. Tabori, C. Hawkins
semanticscholar +1 more source
Medical Hypotheses, 2012 Glial neoplasms account for nearly 50% of all adult primary brain tumors. They originate from glial cells in the brain and/or spinal cord and include low-grade diffuse astrocytomas, anaplastic-astrocytomas, and glioblastomas. Of all brain tumors, glioblastoma multiforme (GBM) is the most aggressive and is characterized by rapid glial cell growth ...
O, Prakash +4 more
openaire +2 more sources
Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang +4 more
wiley +1 more source
Carbonic anhydrase IX as a marker of hypoxia in gliomas: A narrative review
Glioma, 2020 Hypoxia is a powerful driver of the malignant phenotype in solid tumors including gliomas. A major, though not sole, driver of this effect is the hypoxia-inducible factors (HIF) which promote the expression of hundreds of downstream genes through binding
Roger E McLendon
doaj +1 more source
The Glioma Outcomes Project: a resource for measuring and improving glioma outcomes
, 2011 The author describes the Glioma Outcomes (GO) Project which conducts outcomes research and develops educational programs to benefit patients who undergo surgery for glioma.
The Glioma Outcomes Project Advisory Board +1 more
core +1 more source
Arthritis Care &Research, EarlyView.Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source